Currently Funded Projects

Abstracting Device Settings for Comparative Effectiveness of Single vs. Dual Chamber ICDs
This study abstracts implantable cardioverter debrillator device settings to support comparative effectiveness research studies of single vs. dual chamber ICDs within a large cohort of patients with left ventricular systolic dysfunction undergoing ICD implantation for primary prevention of sudden cardiac death at seven large health systems within the Cardiovascular Research Network (CVRN).
Funding Source: Denver Health
PI: Peterson P, UC Denver; Site PI/Co-Investigator: Robert Greenlee, PhD, MPH


CRN Pilot: Are 2 Jars Sufficient for Pathology Examination of Extended Core Prostate Biopsy?
The methodology for submitting extended core prostate biopsy (ECPB) varies widely. There is no currently recommended approach. At present, urologists may process tissue cores into between two and twelve jars. The difference in the number of jars can result in a difference of up to $1000 in costs to insurers. This pilot study will determine the patterns of processing ECPB tissue cores for examination, and determine associations between number of jars and key outcomes (e.g.: rates of prostate cancer detection, equivocal diagnoses). Researchers will accomplish this by using data collected clinically. The goal is to determine the variability in the patterns of number of pathology specimens per biopsy within two sites that have mixed insurance and practice patterns.
Funding Source: Kaiser Foundation Research Institute/NCI
PI: Mara Epstein, University of Massachusetts; Site PI: Robert Greenlee, PhD, MPH


CRN4: Cancer Research Resources & Collaboration in Integrated Health Care Systems
The Cancer Research Network (CRN) is a consortium of research organizations within several non-profit health care delivery systems. Originally, CRN was focused on collaborative research made possible through integrated access to clinical datasets from the participating institutions. This new 5-year cycle uses a different funding mechanism and redefines the role of CRN as a broader resource for cancer researchers at large. The uniqueness of CRN as a cancer resource stems from: (1) the integrated access to clinical data for large, stable, and diverse patient populations that are available through the "parent" HMOs; and (2) the expertise of CRN researchers in conducting clinical cancer research involving large sets of clinical data. Through this, the NCI intends to promote further technical and methodological enhancements of CRN informatics infrastructure as well as efforts to facilitate access of non-CRN-affiliated investigators to CRN data and expertise. The goal is to increase the number and scope of research projects that are based on CRN data and the participation of CRN investigators on such projects. In addition to collaborations on projects funded outside of CRN, CRN will directly support pilot projects that may be initiated either by non-CRN-affiliated investigators or by CRN investigators.
Funding Source: Kaiser Foundation Research Institute/NCI
PI: Larry Kushi, KPNC; Site PI: Robert Greenlee, PhD, MPH


Discharge Order Completeness and 30‐Day Rehospitalizations in Rural Wisconsin Nursing Home Patients
Our long term objective is to improve hospital-to-nursing home discharge communication and thereby, improve nursing home patient safety. In pursuance of this goal and building upon our strong preliminary data, we propose to determine the impact that discharge order omissions have on 30-day rehospitalization in patients discharged from rural Wisconsin hospitals to nursing homes, and to identify how work processes and provider training levels in these hospitals influence discharge order communication.
Funding Source:University of Wisconsin/Wisconsin Partnership Program
PI: Amy Kind, University of Wisconsin; Site PI/Co-Investigator: Robert Greenlee, PhD, MPH


Efforts to Develop the Sentinel Initiative: Detection and Analysis of Adverse Events Related to Regulated Products in Automated Healthcare Data
The goal of this public health surveillance project is to develop a fully functional pilot of FDA's Sentinel System, which will use automated health care data across 19 health care organizations with many millions of covered lives to evaluate post market medical product safety. Mini Sentinel will provide FDA with the ability to analyze information collected during the course of routine health care, such as data from electronic health record systems, administrative and insurance claims databases and medical registries.
Funding Source: Harvard/FDA
PI: Richard Platt, Harvard; Site PI: Robert Greenlee, PhD, MPH


The Greater Plains Collaborative
This is phase 1 development work as one of PCORI’s PCORNet Clinical Data Research Networks, involving 10 academic medical centers to: 1) create a research ready dataset of more than 1 million patients; 2) involve patients, providers, and health systems throughout the research process; 3) develop processes for practical, patient-centered clinical trials that are seamless with health care operations; and, 4) develop cohorts of patients in ALS, breast cancer, and weight/obesity that can be characterized and surveyed in support of future research.
Funding Source: University of Kansas Medical Center/PCORI
PI: Russ Waitman; Site PI: Robert Greenlee, PhD, MPH


Improving Diabetes Quality Reports for Persons with Multiple Chronic Conditions
The specific aim of this developmental work will be to evaluate the utility of existing health care quality reporting data from 3 healthcare systems in Wisconsin to support a more meaningful assessment of health care quality for subjects with multiple chronic conditions. The specific target for this initial work will be retrospective data from the pool of subjects with diagnosed diabetes.
Funding Source: University of Wisconsin/AHRQ
PI: Maureen Smith, University of Wisconsin; Site PI/Co-investigator: Robert Greenlee, PhD, MPH


Longitudinal Studies of Implantable Cardiac Defibrillators (ICDs)
The objective of the study is to evaluate the clinical and device therapy outcomes among patients with left ventricular systolic dysfunction undergoing ICD implantation for primary prevention of sudden cardiac death at seven large health systems within the Cardiovascular Research Network (CVRN).
Funding Source: NHLBI, AHRQ DEcIDE Network, American College of Cardiology Foundation
Co-PI: Frederick Masoudi, UC Denver; Site/Co-PI: Robert Greenlee, PhD, MPH


Midwestern Collaborative for Treating Obesity in Rural Primary Care
This is a multisite, clinic-randomized trial comparing three obesity treatments in adults. Interventions are delivered in primary care settings across several rural clinics in the Midwest.
Funding Source: Patient Centered Outcomes Research Institute
PI: Christie Befort, PhD, University of Kansas Medical Center Research; Site PI: Jeffrey VanWormer, PhD


Mini Sentinel Project: Thromboembolic Events After Immunoglobulin Administration
The Blood Safety Continuous Active Surveillance Network (Blood-SCAN) is a Task Order under the Mini Sentinel pilot that aims to develop a claims-based active surveillance system for FDA-rcgulatcd blood components and blood-derived products. As part of the Blood-SCAN activities, we will conduct a one-time, retrospective protocol-based assessment of thromboembolic events (TEE) after immunoglobulin administration and validate the algorithms used to identify the exposure and the outcome. There are 13 different FDA approved products of interest. The majority of Ig use is via the intravenous route (IV), though some products are available for intramuscular (IM) or subcutaneous (SC) administration.
Funding Source: Harvard Pilgrim Health Care, Inc. /FDA
PI: Richard Platt, Harvard; Site PI: Robert Greenlee, PhD, MPH


Mini Sentinel Project: Workgroup Activities for Task Order 7 (20 Potential Exposure/Outcome Associations)
This Task Order seeks to use the tools, resources and data environments of the Mini Sentinel pilot to examine potential associations of exposures to a drug with specified adverse outcomes under several sets of conditions. This SOW provides support to run standard workplans for workgroup activities funded under this Task Order for up to 20 exposure outcome pairs.
Funding Source: Harvard Pilgrim Health Care, Inc. /FDA
PI: Richard Platt, Harvard; Site PI: Robert Greenlee, PhD, MPH


Wisconsin NCI Community Oncology Research Program (WiNCORP)
A consortium between Marshfield Clinic, Gundersen Health Systems, and St. Vincent Regional Cancer Center, WiNCORP’s overarching goal is to provide access to NCI-sponsored clinical trials to over 680,000 community members residing within a collective, largely rural service area spanning most of the state of Wisconsin, upper Michigan, and adjacent counties in Iowa and Minnesota. WiNCORP was among only 14 of 40+ NCORP community sites to be selected for enhanced Cancer Care Delivery Research as part of network activities.
Funding Source: National Cancer Institute
PI: Douglas Reding; Co-Investigator, Cancer Care Delivery Research Lead: Robert Greenlee, PhD, MPH


Recently Completed Projects

Injuries from Tree Stand Falls Among Wisconsin Deer Hunters (Completed September 2014)
This project will leverage Marshfield Clinic data to examine annual trends and characteristics of medically-attended injuries from tree stand falls among whitetail deer hunters in central Wisconsin. The specific aims are to: 1) estimate the most recent 5-year trends in injuries from tree stand falls; 2) describe the demographic and clinical characteristics of injured patients; and 3) characterize tree stand fall injury features and (known) precipitating factors.
Funding Source: NFMC Endowment
PI: Jeffrey VanWormer, PhD


FDA Mini Sentinel Project/Foundational Elements: Case Identification, Validation, and Adjudication of Severe Kidney Injury (Completed August 2013)

The goals of this project are to develop an algorithm for identifying severe kidney injury cases in the Mini Sentinel database, and identify the positive predictive value of ICD-9 codes for identifying such cases.
Funding Source: Harvard Pilgrim Health Care, Inc. /FDA
PI: Richard Platt, Harvard; Site PI: Jeffrey VanWormer, PhD


FDA Mini Sentinel Project/Foundational Elements: Case Identification, Validation, and Adjudication of Severe Liver Injury (Completed March 2012)
The goals of this project are to develop an algorithm for identifying severe acute liver injury cases in the Mini Sentinel database, and identify the positive predictive value of ICD-9 codes for identifying such cases.
Funding Source: Harvard Pilgrim Health Care, Inc. /FDA
PI: Richard Platt, Harvard; Site PI: Jeffrey VanWormer, PhD