Center for Clinical Epidemiology and Population Health (CCEPH) investigators direct dozens of research projects totaling more than $3 million in annual funding and are actively involved in numerous collaborative studies with the following networks:

CDC Influenza Vaccine Effectiveness Network:

The U.S. Flu Vaccine Effectiveness (VE) Network is a Centers for Disease Control and Prevention (CDC) - funded collaboration to assess the effectiveness of influenza vaccination each season. Patients seeking outpatient care for acute respiratory illness are actively recruited during the flu season, and consenting individuals are tested for influenza using a molecular diagnostic test (PCR). Vaccination status is compared for influenza cases and 'test-negative' controls to estimate vaccine effectiveness. CCEPH has been continuously funded by CDC to conduct vaccine effectiveness research since the 2004-05 season. The U.S. Flu VE Network currently includes study sites in Seattle, WA; Temple, TX; Ann Arbor, MI; and Pittsburgh, PA in addition to Marshfield. The U.S. Flu VE Network generates mid-season estimates of influenza vaccine effectiveness that are published in the Morbidity and Mortality Weekly Report (MMWR)and final results are published in peer-reviewed journals. Mid-season VE results are also presented to the WHO (World Health Organization) Vaccine Strain Selection Committee in February. Marshfield investigators have led ancillary studies to investigate the effects of repeated vaccination and statin use on vaccine effectiveness, and studies of vaccine immune response.

CDC Vaccine Safety Datalink:

Vaccine Safety Datalink (VSD) is a collaborative project between the Centers for Disease Control and Prevention (CDC) and nine research managed care organizations (MCOs) in the United States. Established in 1990 to conduct post-marketing evaluations of vaccine safety, the VSD conducts high-quality research to determine the risk of adverse events after immunization. The Marshfield Clinic Research Institute (MCRI) joined the VSD in 2001, and the VSD team is led by investigators in the Center for Clinical Epidemiology and Population Health (CCEPH). Marshfield Clinic and Security Health Plan play a key role contributing data to the only rural population in the VSD network. CCEPH researchers have led and published results of studies to evaluate the safety of several vaccines including rotavirus vaccines, influenza vaccines during pregnancy, varicella (chickenpox) vaccines, and the HPV vaccine.

FDA Mini-Sentinel:

FDA Mini-Sentinel is a 5-year pilot project sponsored by the U.S. Food and Drug Administration (FDA) to create an active national surveillance system to monitor the post-market safety of FDA-regulated medical products. Classified as public health surveillance rather than research, Mini-Sentinel relies on pre-existing electronic healthcare data from 19 data partner organizations that are kept secured at each institution, but standardized to a common data model to allow for efficient data querying. Collaborating institutions, such as Marshfield Clinic Research Institute (MCRI), provide responses to project data queries as well as scientific and organizational expertise. CCEPH has been involved in the Mini-Sentinel since 2008, addressing important topics including severe liver injury, acute kidney injury, and surveillance methodology.

Health Care Systems Research Network:

The Health Care Systems Research Network (HCSRN) brings together the research departments of some of the nation's best and most innovative health care systems. Collectively, the HCSRN represents over 1,400 scientists and research staff with methodological and content expertise from an array of disciplines including epidemiology, economics, disparities, outcomes and quality assessment, trials, genomics, and more. CCEPH scientists have been conducting studies in collaboration with HCSRN partners since 2006 on a variety of topics, with primary focus on topics in cancer, cardiovascular disease, and medical product safety.

NCI Cancer Research Network:


The Cancer Research Network (CRN) is a National Cancer Institute (NCI)-funded initiative to support and facilitate cancer research based in non-profit integrated health care delivery settings. Since 2007, CCEPH has been a funded partner in the CRN and has conducted research on topics that include: colorectal cancer screening effectiveness; prostate cancer detection; advanced medical imaging radiation exposure and cancer risk; nutritional assessment; lymphoma risk factors; and, weight change and breast cancer risk.  To see a map of participating and affiliate CRN sites, click here.

NHLBI Cardiovascular Research Network:

The Cardiovascular Research Network (CVRN) is an National Heart, Lung and Blood Institute (NHLBI)-funded collaborative that leverages expertise, populations, and data sources from a consortium of 14 geographically diverse health plans (11 million members) in the United States with integrated research divisions. The overall goals are to provide robust cardiovascular disease (and associated healthcare) surveillance and promote research on clinical practice and quality of care. CCEPH has been an active partner in this network since 2007 and has participated in associated research projects on myocardial infarction, implantable cardiac defibrillators, anticoagulation therapy, and genetics, among other topics.

University of Wisconsin Institute for Clinical and Translational Research, Community Engagement and Research Core:

The goal of the University of Wisconsin Institute for Clinical and Translational Research (ICTR) is to create an environment that transforms research training and research practice into a full continuum from discovery to translation into real-world community practice. The mission is to change the research culture from “silos” to collaborations among ICTR members, the entire university, and ICTR's external partner Marshfield Clinic. Major advancements in clinical and translational research are occurring. CCEPH is the home of Marshfield Clinic Research Institute's (MCRI) Community Engagement and Research Core, with core staff providing service to ICTR investigators in collaborator matching, research design, study development and support, and community engagement for population research. Also, CCEPH investigators have collaborated on research with ICTR partners on topics that include lupus, kidney stones, asthma and other allergies, diabetes, oral health, reducing unnecessary hospitalizations, and health care quality reporting.