Research Operations

CCEPH Research Operations support and deliver high quality research coordination services to internal and external PhD and Clinician investigators. Research Coordinators are trained to identify and recruit subjects, obtain informed consent, collect and/or abstract data, obtain specimens, and manage project needs and events unitizing quality assurance practices. Our Research Coordination staff is available to manage research protocols for Marshfield Clinic Research Foundation investigators and Marshfield Clinic Clinicians. In addition, our Research Coordination services are available to collaborators.

Investigator Consultations

CCEPH provides consulting on clinical epidemiology and public health project ideas as they relate to hypothesis formulation, appropriate study designs, data collection and analysis, interpretation of results, and manuscript preparation. We advise on the strengths and limitations of Marshfield Clinic data, especially MESA and larger cohorts that MESA contributes. We also provide expertise on minimizing biases that affect study validity. Specifically, we can recommend appropriate study criteria for patient inclusion to avoid selection bias, and methods to assess outcomes, exposures and covariates of interest to minimize information biases and confounding. We also provide sample size estimation for study feasibility. Overall, we are an important resource that helps researchers identify the right sample, methods, and analyses to accomplish their study objectives.

Informatics Analytics

CCEPH has available to its investigators and collaborators biostatistical and informatics analytic resources. CCEPH’s Biostatistician and Programmer/Analysts are integral members of a multidisciplinary research team and provide support to internal and external investigators. They are involved in statistics, study design, data analysis, data management, and custom computer programming designed to meet project and protocol needs.

Integrated Research and Development Laboratory (IRDL)

The Integrated Research and Development Laboratory (IRDL) is a separate resource within the Marshfield Clinic Research Foundation (MCRF) directed by Jennifer Meece, PhD. IRDL members perform and publish their own original research on Blastomyces dermatiditis, vector-borne diseases, and influenza while also providing diagnostic research support and scientific guidance on many studies in collaboration with CCEPH and other departments within MCRF.

IRDL owns and maintains instrumentation that is capable of supporting the following research:

  • Bacteriology/virology
  • Genetics and genotyping
  • Molecular microbiology
  • General molecular biology
  • Cell and tissue culture

IRDL has provided essential research support for the 10 years Marshfield Clinic has been a site for the US Flu Vaccine Effectiveness (VE) Network.  IRDL's proficiency has earned the lab the role of providing support to external collaborators across the United States.  In addition to the Flu VE Network, the lab provides reference testing for national studies of influenza infection in pregnant women and community-based studies of influenza.  IRDL has the distinction of being the reference lab to confirm the first H1N1 influenza positive in the United States during the 2009 swine flu pandemic.