Associate Research Scientist (Tenure-Track)

Center for Human Genetics, MLR
Marshfield Clinic
1000 North Oak Avenue
Marshfield, WI 54449

715.221.6443

Email 


  Steven-Schrodi

Dr. Steve Schrodi’s research focuses on two scientific areas: large-scale genetic studies of inflammatory diseases and theoretical genetics. His work combines experimental studies, statistical models, and the development of genetics theory. Dr. Schrodi completed his Bachelor’s degree in genetics at the University of California – Davis and his Master’s and doctoral degrees in biology at the University of California – Irvine where he researched theoretical population genetics. His previous research experience at Celera (Alameda, CA) emphasized the application of probabilistic methods to genome-wide association studies and mapping of autoimmune diseases.

 




CURRENT RESEARCH INTERESTS:

  • Although inflammation is critical to proper response to infection and general immunocompetence, dysregulation of inflammatory pathways is a fundamental departure from homeostasis that underlies a wide variety of chronic and acute diseases. We are currently conducting a number of studies including Th17 cytokine signaling, mapping disease variants using extended kinships, inference of innate and adaptive immunity gene networks, the genetics of hyper-responsive lymphocytes, and the development of predictive models for immune-metabolic dysfunction. We are using molecular intermediate phenotype approaches in an attempt to better dissect the complexity of chronic inflammatory diseases. The majority of our studies make use of the Personalized Medicine Research Project at the Marshfield Clinic Research Foundation. Understanding the inherited and acquired molecular aberrations that cause pathogenic inflammation will provide key insights for disease avoidance and remediation, potentially through the development of new targeted therapeutics
  • Diseases studied include: Ankylosing Spondylitis, Psoriasis, Rheumatoid Arthritis, Multiple Sclerosis, Type 2 Diabetes, Autism, Host Susceptibility to Infectious Diseases, and Rare Immunological Diseases.
  • Our theoretical and statistical work involves the development of probabilistic methods to analyze sequence data, the application of information theory metrics to quantify prognostic utility using molecular data, linkage disequilibrium patterns under disease models, and genetic properties of large founder populations.

OUTSIDE COLLABORATORS INCLUDE:

Judith A. Smith, M.D., Ph.D. – Department of Pediatrics, University of Wisconsin – Madison
Miriam Shelef, M.D., Ph.D. – Department of Medicine, Rheumatology Division, University of Wisconsin – Madison
Mark Leppert, Ph.D. – Department of Human Genetics, University of Utah
Norisada Matsunami, M.D., Ph.D. – Department of Human Genetics, University of Utah
Janet Lainhart, M.D. – Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin – Madison
Nicholas Lange, Sc.D. – Neurostatistics, McLean Hospital; Departments of Biostatistics and Psychiatry, Harvard Medical School 
Mehdi Maadooliat, Ph.D. – Mathematics, Statistics and Computer Science, Marquette University
Naveen Bansal, Ph.D. – Mathematics, Statistics and Computer Science, Marquette University


 United States Patents Issued

  • “Genetic polymorphisms associated with psoriasis, methods of detection and uses thereof”, United States Patent 8975022; Filed Aug 12, 2012; Issued: Mar 10, 2015
  • “Genetic polymorphisms associated with psoriasis, methods of detection and uses thereof”, United States Patent 7993833; Filed Aug 31, 2007; Issued: Aug 9, 2011
  • “Genetic polymorphisms associated with psoriasis, methods of detection and uses thereof” United States Patent 7947451; Filed: Dec 1, 2008; Issue: May 24, 2011
  • “Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof”, United States Patent 7863021; Filed: Sept 5, 2007; Issued: Jan 4, 2011
  • “Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof”, United States Patent 7833706; Filed: Jan 30, 2004; Issued: Nov 16, 2010
  • "Genetic polymorphisms associated with psoriasis, methods of detection and uses thereof", United States Patent 9371565; Filed Jan 26, 2015; Issued:  Jun 21, 2016

SELECTED PUBLICATIONS

Schrodi SJ. The Use of Multiplicity Corrections, Order Statistics and Generalized Family-Wise Statistics with Application to Genome-Wide Studies. PLOS ONE 2016;11(4):e0154472. PubMed ID: 27128491

Schrodi SJ, DeBarber A, He M, Ye Z, Peissig P, Van Wormer JJ, Haws R, Brilliant MH, Steiner RD. Prevalence estimation for monogenic autosomal recessive diseases using population-based genetic data. HUM GENET 2015;134(6):659-669. PubMed ID: 25893794

Schrodi SJ, Mukherjee S, Shan Y, Tromp G, Sninsky JJ, Callear AP, Carter TC, Ye Z, Haines JL, Brilliant MH, Crane PK, Smelser DT, Elston RC, Weeks DE. Genetic-based prediction of disease traits: prediction is very difficult, especially about the future. FRONT GENET 2014;5:162. PubMed ID: 24917882

Hebbring SJ, Slager SL, Epperla N, Mazza JJ, Ye Z, Zhou Z, Achenbach SJ, Vasco DA, Call TG, Rabe KG, Kay NE, Caporaso NE, Lanasa MC, Camp NJ, Strom SS, Goldin LR, Cerhan JR, Brilliant MH, Schrodi SJ. Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia. BLOOD 2013;121:237-8. PubMed ID: 23287625

Garcia VE, Chang M, Brandon R, Li Y, Matsunami N, Callis-Duffin KP, Civello D, Rowland CM, Bui N, Catanese JJ, Krueger GG, Leppert MF, Begovich AB, Schrodi SJ. Detailed genetic characterization of the interleukin-23 receptor in psoriasis. GENES IMMUN 2008;9(6):546-555. PubMed ID: 18650833

Chang M, Li Y, Yan C, Callis-Duffin KP, Matsunami N, Garcia VE, Cargill M, Civello D, Bui N, Catanese JJ, Leppert MF, Krueger GG, Begovich AB, Schrodi SJ. Variants in the 5q31 cytokine gene cluster are associated with psoriasis. GENES IMMUN 2008;9(2):176-181. PubMed ID: 18075513

Cargill M*, Schrodi SJ*, Chang M, Garcia VE, Brandon R, Callis KP, Matsunami N, Ardlie KG, Civello D, Catanese JJ, Leong DU, Panko JM, McAllister LB, Hansen CB, Papenfuss J, Prescott SM, White TJ, Leppert MF, Krueger GG, Begovich AB. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. AM J HUM GENET 2007;80(2):273-290. PubMed ID: 17236132

Schrodi SJ. A probabilistic approach to large-scale association scans: a semi-Bayesian method to detect disease-predisposing alleles. STAT APPL GENET MOL BIOL 2005;4:Article 31. PubMed ID: 16646850

Schrodi, SJ. Reflections on the Field of Human Genetics:  A Call for Increased Disease Genetics Theory. FRONT GENET. 2016 Jun 8;7:106. doi. 10/3389/fgene.2016.00106. eCollection2016.  PubMed ID: 27375680

Carter TC, Rein D, Padberg I, Peter E, Rennefahrt U, David DE, McManus V, Stefanshi E, Martin S, Schatz P, Schrodi, SJ. Validation of a metabolite panel for early diagnosis of type 2 diabetes. METABOLISM. 2016 Sep:65(9):1399-408. doi. 10.1016/jmetabol.2016.06.007. Epub 2016 Jun 26. PubMed ID: 27506746

Schrodi, SJ, Garcia VE, Rowland C, Jones HB. Pairwise linkage disequilibrium under disease models. EUR J HUM GENET. 2007 Feb;15-(2):212-20. Epub 2006 Nov 15. PubMed ID: 17106449