• Steven Schrodi PhD

  • Assoc. Research Scientist-Genetics


    • Center for Precision Medicine Research
    • 1000 North Oak Ave. MLR Marshfield, WI 54449

Education


2001:
PhD, Biological Sciences, Laboratory of Walter M. Fitch, University of California, Irvine, CA
1998:
MS, Biological Sciences, Laboratory of Richard R. Hudson, University of California, Irvine, CA
1995:
BS, Genetics, University of California, Davis, CA
1992:
Internship, Space Science, Theoretical Space Science Division, NASA Ames Research Center, Moffett Federal Airfield, CA

Work Experience


2019 to Present:
Section Editor, Genetics in Medicine
2015 to Present:
Associate Editor, Frontiers in Genetics
2013 to Present:
Faculty Trainer, Computation and Informatics in Biology and Medicine, University of Wisconsin, Madison
2010 to Present:
Associate Research Scientist, Center for Human Genetics - Marshfield Clinic Research Institute, Marshfield
2008 to 2010:
Senior Staff Scientist, Celera , Alameda, CA
2006 to 2008:
Staff Scientist, Celera , Alameda, CA
2001 to 2006:
Senior Scientist, Celera , Alameda, CA
2000 to 2001:
Scientist, DNA Sciences, Fremont, CA

Honors & Awards


1992:
Excellence in Research Award, NASA Ames Research Center
2004:
Top 10 Arthritis Advances of 2004 - Arthritis Foundation
2005:
UCSF Frontiers in Neurology & Neuroscience, Keynote Speaker
2007:
Applera Demonstrated Noteworthy Achievement Award
2010:
US Patent 7,833,706; Inventor
2011:
US Patent 7,863,021; Inventor
2011:
US Patent 7,947,451; Inventor
2011:
US Patent 7,993,833; Inventor
2015:
US Patent 8,975,022; Inventor
2016:
US Patent 9,371,565; Inventor
2018:
US Patent 10,006,088; Inventor
2018:
US Patent 10,113,198; Inventor
2018:
US Patent 10,131,949; Inventor
2019:
Twenty-one US Patent Applications, Inventor
2019:
>6,500 Citations

Statement


Dr. Schrodi's training was in theoretical population genetics. He has conducted human genetics and statistical genetics research for the past 18 years. He has mapped genes underlying rheumatoid arthritis, psoriasis, ankylosing spondylitis, multiple sclerosis, idiopathic short stature, type 2 diabetes, inflammatory cytokine expression, bacterial infection, and autism. His work in statistical genetics has focused on Bayesian methods, multiplicity, and linkage disequilibrium patterns.

Research Interests


Dr. Schrodi's primary areas of research lie in complex disease genetics with a focus on systemic inflammatory diseases and metabolic conditions. In addition, he actively develops disease genetics theory and the construction of novel statistical genetics methods.

Professional Societies


International Society of Bayesian Analysis, Member
American Society of Human Genetics, Member
American College of Medical Genetics and Genomics, Member

Committees


New England Journal of Medicine, Ad hoc Reviewer
Nature, Ad hoc Reviewer
Journal Investigative Dermatology, Ad hoc Reviewer
Genes and Immunity, Ad hoc Reviewer
American Naturalist, Ad hoc Reviewer
Genetics, Ad hoc Reviewer
Arthritis and Rheumatism, Ad hoc Reviewer
Annals of Neurology, Ad hoc Reviewer
Computational Statistics and Data Analysis, Ad hoc Reviewer
Scientific Advisory Board: DNA Sciences, Board Member
Pharmaceutical Statistical Genetics Consultant, Consultant
Molecular Psychiatry, Ad hoc Reviewer
Human Immunology, Ad hoc Reviewer
Genetics in Medicine, Ad hoc Reviewer
BMC Genomics, Ad hoc Reviewer
Diabetologia, Ad hoc Reviewer
Critical Assessment of Massive Data Analysis, Scientific Committee Member
Multiple Sclerosis Research Australia , Grants Reviewer
ICTR Grant Review Panel, Grants Reviewer
KL2 Scholar Advisory Committee, Member

Presentations


1993:
Influence of Electrostatic Charges on the Movement of Dust by Wind, NASA Ames Research Center
1995:
A Method for the in vitro evolution of proteins, Department of Molecular Biology and Biochemistry, UC Irvine
1996:
Increasing Dispersion Index in Mammals, Integrative Biology Group, UC Berkeley
1998:
Discerning Temporal Effects of the Dispersion Index, Molecular Biology and Evolution Society Meeting on Molecular Evolution, Candad
1998:
Haploid Models, Pacific Institute of Mathematics
1999:
The Mathematics of Biological Systems, Mathematics Lecture Series
2000:
Transition Properties of Diffusion Processes, Mathematics Series on Diffusion Equations
2000:
Mathematical Models of Self-Replicating Systems, Skaggs Institute of Chemical Biology
2000:
Testing Hypotheses with Expression Data: Part II, Incyte Genomics Conference
2000:
Testing Hypotheses with Expression Data: Part I, Incyte Genomics Conference
2000:
Inference of Biochemical Networks from Expression Data, Yeast Genomics Conference
2002:
Using Population Genetics to Inform Linkage Disequilibrium Studies, Haplotype Summit I
2003:
Genome-wide comparative sequence analysis between human, mouse, and chimpanzee identifies genes under positive selection, American Society of Human Genetics
2003:
Genome Wide Survey for Common Polymorphisms in Human Genes, GASC Conference
2004:
Identification of Novel Genetic Markers Associated with Fibrosis Progression Risk in HCV Patients from a Genomic Scan of Putative Functional Polymorphisms, American Association for the Study of Liver Diseases
2004:
Association of late onset Alzheimer’s disease with genetic variation in multiple members of a gene family involved in neuronal apoptosis, Neurobiology of Aging Conference
2004:
A Missense SNP in the Protein Tyrosine Phosphatase PTPN22 is Associated with Rheumatoid Arthritis, Annual European Congress of Rheumatology
2004:
Association of Late-Onset Alzheimer's Disease with Genetic Variation in Multiple Members of the GAPD Gene Family, 9th International Conference on Alzheimer's Disease and Related Disorders
2004:
A Systematic Scan of Chromosome 10 Single Nucleotide Polymorphisms Identifies Novel Candidate Genes Showing Strong Association to Alzheimer's Disease, 9th International Conference on Alzheimer's Disease and Related Disorders
2005:
Induction Ideas for Large-Scale Genetic Analyses and Fine-Scale Mapping of PTPN22, Ernest Gallo Clinic and Research Center, UCSF
2005:
Discovery and Utility of Disease Genes: Results and Lessons from Association Mapping Studies, UCSF Frontiers in Neurology and Neuroscience
2005:
Novel Genetic Markers Associated With Risk Of Non-Alcoholic Steatohepatitis In Patients With Non-Alcoholic Fatty Liver Diseases, Digestive Disease Week
2005:
Association of Fibrosis Risk in HCV Patients with a Missense SNP in Gene CPT1A, 40th Annual Meeting of the European Association for the Study of the Liver (EASL)
2005:
Association of fibrosis risk in HCV patients with a missense single nucleotide polymorphism in a gene encoding carnitine palmitoyl-transferase 1A (CPT1A), Hepatology Conference
2006:
Characterizing susceptibility to phenotypic variations of psoriasis by comparing allelic association signals on PSORS loci chromosomes, Investigative Dermatology Conference
2007:
Large-Scale Association Mapping and Genetic-Based Prognosis, Washington University
2007:
A large-scale rheumatoid arthritis genetic study identifies TRAF1 variants on chr 9q33.2, American Society of Human Genetics
2007:
Phenotype/genotype of psoriasis that worsens with infection, World Congress of Dermatology
2007:
Detailed genetic characterization of the psoriasis-associated gene IL23R, 68th Annual Meeting of the Society for Investigative Dermatology
2007:
Association of phenotypic characteristics of psoriasis with the IL-12B and IL-23R psoriasis risk single nucleotide polymorphisms (SNPs), Investigative Dermatology
2007:
Detailed genetic characterization of the psoriasis-associated gene IL12B to further define the causal variant(s), Investigative Dermatology
2008:
Mapping Common Disease Genes through Association: Theory and Experiment, BSRI, San Francisco, CA
2008:
Common Genetic Polymorphisms Associated with Advanced Fibrosis in Patients with CHC are associated with Risk of Non-Alchoholic Steatohepatitis and Cirrhosis in Patients with NAFLD, American Association for the Study of Liver Diseases
2008:
Phenotypic and genotypic profile of psoriatic patients with asthma, International Investigative Dermatology Meeting
2008:
Association and linkage of the TRAF1/C5 region with specific subsets of rheumatoid arthritis, 28th European Workshop for Rheumatology Research
2009:
Mapping Common Disease Genes through Association: Theory and Experiment. Institute of Human Genetics, UCSF
2009:
Trait Prediction using Multi-Locus Information: Psoriasis as a Model for Complex Disease Prognosis, International Society of Genetic Epidemiology, Hawaii
2009:
A fine mapping theorem to refine results from association genetic studies, American Society of Human Genetics
2009:
A Common, Functional Polymorphism in DDX5 is Associated with Cirrhosis in Chronic Hepatitis C and NAFLD Patients, Digestive Disease Week/Hepatology
2009:
An IL13 polymorphism that associates with psoriasis and protects risk of psoriatic arthritis is abrogated by smoking, 69th Annual Meeting of the Society of Investigative Dermatology
2009:
Psoriasis as a model for complex disease prognostics, 18th Annual Meeting of the International Genetic Epidemiology Society
2010:
Mapping Common Disease Genes through Association: Theory and Experiment, Oregon Health Sciences University
2010:
Mapping Common Disease Genes through Association: Theory and Experiment. , Virginia Institute for Psychiatric and Behavioral Genetics
2010:
Mapping Common Disease Genes through Association: Theory and Experiment, Vanderbilt University
2010:
Structural Variation and Pharmacogenetics of Idiopathic Short Stature, Ipsen, Paris, France
2012:
Clinical Genomics: Genetic Prediction of Pharmacological Response to Lercanidipine and Risk of Hypertension, Critical Assessment of Massive Data Analysis, Long Beach, CA
2012:
Coalescent inference of evolutionary parameters using serially sampled genomic sequence data: theory and applications in human population genetics, American Society of Human Genetics
2012:
A screen of TLR polymorphisms in a cohort of term infants reveals differences in allele frequencies compared to published frequencies, PAS Workshop
2012:
Analysis of TLR4 SNPs 299 and 300 in a population of full term Wisconsin infants, American Society of Human Genetics
2012:
Turning the GWAS upside down: a PheWAS approach in studying human disease, American Society of Human Genetics
2012:
Population genetic inference for a whole genome Korean sample, Critical Assessment of Massive Data Analysis
2012:
Characterization and analysis of Korean genomes, Critical Assessment of Massive Data Analysis
2012:
Pharmacogenomics in the Pocket of Every Patient? -A Prototype Card with Quick Response (QR) Code, Critical Assessment of Massive Data Analysis
2013:
Human Genetics, the Genomics of Cytokine Expression, and PTPN22 Pleiotropy, Marshfield, Wisconsin
2013:
Molecular intermediate phenotype mapping of IL-6 and TNFa levels reveals genes critical for chronic inflammation, American Society of Human Genetics
2013:
Use of Electronic Medical Records to Measure Phenotypic Heritability, American Society of Human Genetics
2013:
PheWAS – A Novel Method that Combines Genetics and Medical Informatics, NLM Informatics Training Conference
2013:
A Genome Wide Association Study to Determine the Susceptibility to Staphylococcus aureus Infection, American Society of Human Genetics
2013:
TLR SNP T399I and early gestational age in a Wisconsin population of black newborn infants, American Society of Human Genetics
2013:
Dramatic improvement in accuracy and time to reporting when identifying cystic fibrosis pathogens: the practical impact of mass spectrometry, American Society for Microbiology
2013:
Prognostic Utility of Single-Nucleotide Polymorphisms in Inflammatory Arthritis, MCRF Summer Research Symposium
2014:
Genetic Architecture of Human Complex Disease and Genetic-Based Predictive Models, UW-Madison, Wisconsin
2014:
Antibody Screening, Antigen Discovery, Irvine, CA
2014:
Interpretation of Data, Marshfield, Wisconsin
2014:
Outperforming fasting plasma glucose, metabolite biomarkers and their role in diabetes, American Diabetes Association
2014:
MinION device: Latest advancements in next-generation DNA sequencing, MCRF Summer Research Symposium
2014:
Lyp's implications cause both increased or decreased susceptibility towards autoimmune and acquired diseases, Experimental Biology
2014:
Pathway in Axial Spondyloarthritis, Rheumatology Research Foundation Investigator meeting
2015:
Large-scale phenome-wide scan in twins using electronic health records, American Society of Human Genetics
2015:
An exome wide genotyping study using SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections, MCRF Summer Research Symposium
2015:
Phenome-wide association study provides biologic insights into the etiology of age-related macular degeneration, American Society of Human Genetics
2016:
Research in Genetic Models: Applied Probability in Population Genetics and Human Genetics, Marquette University, Wisconsin
2016:
Phenome-wide association study provides insights into the etiology of age-related macular degeneration, ARVO
2016:
Analytic Bayesian Calculations for Human Genetic Data, International Society for Bayesian Analysis
2017:
A Survey of Four Disease Genetics Investigations using the Personalized Medicine Research Project, UW-Madison, Wisconsin
2017:
Medical Interventions Program, Future of Genetics, Keynote Speaker, Wisconsin
2017:
White Matter Microstructures as Candidate Brain Phenotypes of Autism, International Society for Autism Research
2017:
Large-scale phenome-wide scan in twins helps identify candidate variants associated with seborrheic keratosis, American Society of Human Genetics
2018:
Medical Interventions Program, Future of Genetics, Keynote Speaker, Wisconsin
2018:
The Discovery of Rheumatoid Arthritis Susceptibility Genes, Keynote Speaker, Shanghai, China
2018:
Neurite orientation dispersion and density imaging in autism spectrum disorders, International Society for Autism Research
2018:
Single nucleotide polymorphism in the gene encoding peptidylarginine deiminase 4 correlates with reduced neutrophil extracellular traps and anti-histone antibodies in rheumatoid arthritis, American College of Rheumatology
2019:
Two novel approaches for mapping disease genes with applications to iron overload and rheumatoid arthritis, University of North Texas

Select Publications


  • Guo S, Jiang S, Epperla N, Ma Y, Maadooliat M, Ye Z,...Schrodi SJ [including Olson B, Kitchner T, Joyce J, Strenn R, Mazza JJ, Meece JK.] A gene-based recessive diplotype exome scan discovers FGF6, a novel hepcidin-regulating iron metabolism gene. [published online ahead of print 2019 February 27]. BLOOD. doi: doi: 10.1182/blood-2018-10-879585.
    PubMed ID: 30814063
  • Bansal NK, Maadooliat M, Schrodi SJ. Empirical Bayesian approach to testing multiple hypotheses with separate priors for left and right alternatives. Stat Appl Genet Mol Biol. 2018 July 5;
    PubMed ID: 29975669
  • Schrodi SJ. (2017 January 17). Postmortem Genetic Testing for Sudden Unexpected Death. JAMA. 317(3):320-21.
    PubMed ID: 28114545
  • Liu Y, Ye Z, Li X, Anderson JL, Khan M, DaSilva D,...Smith JA [including Wilson D, Bocoun V, Ivacic LC, Schrodi SJ.] (2017). Genetic and Functional Associations with Decreased Anti-inflammatory Tumor Necrosis Factor Alpha Induced Protein 3 in Macrophages from Subjects with Axial Spondyloarthritis. Front Immunol. 8 :860.
    PubMed ID: 28791018
  • Schotthoefer AM, Schrodi SJ, Meece JK, Fritsche TR, Shukla SK. (2017). Pro-inflammatory immune responses are associated with clinical signs and symptoms of human anaplasmosis. PLoS One. 12(6):e0179655.
    PubMed ID: 28628633
  • Schrodi SJ. (2017 October 18). The Impact of Diagnostic Code Misclassification on Optimizing the Experimental Design of Genetic Association Studies. J Healthc Eng. 2017 :7653071.
    PubMed ID: 29181145
  • Schrodi SJ. (2016). The Use of Multiplicity Corrections, Order Statistics and Generalized Family-Wise Statistics with Application to Genome-Wide Studies. PLoS One. 11(4):e0154472.
    PubMed ID: 27128491
  • Schrodi SJ. (2016). Reflections on the Field of Human Genetics: A Call for Increased Disease Genetics Theory. Front Genet. 7 :106.
    PubMed ID: 27375680
  • Tokarz SA, DeValk J, Luo W, Pattnaik BR, Schrodi SJ, Pillers DA. (2016 July). Cell line donor genotype and its influence on experimental phenotype: Toll-like receptor SNPs and potential variability in innate immunity. Mol Genet Metab. 118(3):147-52.
    PubMed ID: 27324283
  • Carter TC, Rein D, Padberg I, Peter E, Rennefahrt U, David DE,...Schrodi SJ [including McManus V, Stefanski E.] (2016 September). Validation of a metabolite panel for early diagnosis of type 2 diabetes. Metab. Clin. Exp.. 65(9):1399-408.
    PubMed ID: 27506746
  • Brilliant MH, Vaziri K, Connor TB, Schwartz SG, Carroll JJ, McCarty CA,...McKay BS [including Schrodi SJ, Hebbring SJ.] (2016 Mar). Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration. Am J Med. 129(3):292-8.
    PubMed ID: 26524704
  • Maadooliat M, Bansal NK, Upadhya J, Farazi MR, Li X, He MM,...Schrodi SJ [including Hebbring SJ, Ye Z.] (2016 December 12). The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem. Front Genet. 7 :217.
    PubMed ID: 28018425
  • Ye Z, Mayer JG, Ivacic LC, Zhou Z, He M, Schrodi SJ,...Hebbring S [including Brilliant MH.] (2015 April). Phenome-wide association studies (PheWASs) for functional variants. Eur J Hum Genet. 23(4):523-9.
    PubMed ID: 25074467
  • Schrodi SJ, Debarber A, He M, Ye Z, Peissig PL, VanWormer JJ,...Steiner R [including Haws RM., Brilliant MH.] (2015 June). Prevalence estimation for monogenic autosomal recessive diseases using population-based genetic data. Hum Genet. 134(6):659-69.
    PubMed ID: 25893794
  • O'Brien S, Schrodi SJ, Brilliant MH, Virani S, Brautbar A. (2015 August). Differential Lipid Response to Statins is Associated with Variants in the BUD13-APOA5 Gene Region. J Cardiovasc Pharmacol.. 66(2):183-8..
    PubMed ID: 25900265
  • Shukla SK, Rose W, Schrodi SJ. (2015 June). Complex host genetic susceptibility to Staphylococcus aureus infections. Trends Microbiol.. :pii: S0966-842X(15)00128-6.
    PubMed ID: 26112911
  • He M, Person TN, Hebbring S, Heinzen E, Ye Z, Schrodi SJ,...Wang K [including McPherson EW, Peissig PL, Brilliant MH.] (2015 April). SeqHBase: a big data toolset for family based sequencing data analysis. JOURNAL OF MEDICAL GENETICS. 52(4):282-8.
    PubMed ID: 25587064
  • Shukla SK, Cook D, Meyer J, Vernon SD, Le T, Clevidence D,...Frank DN [including Schrodi SJ.] (2015). Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). PLoS One. 10(12):e0145453.
    PubMed ID: 26683192
  • Schrodi SJ, Jones HB. (2015 September 2). Calculating Exact P-Values from the McNamara Transmission/Disequilibrium Test Statistic. Journal of Investigative Genomics. 2(4):00032.
  • Schrodi SJ, Mukherjee S, Shan Y, Tromp G, Sninsky JJ, Callear AP,...Weeks DE [including Carter TC, Ye Z, Brilliant MH.] (2014 June). Genetic-based prediction of disease traits: prediction is very difficult, especially about the future(†). Front Genet. 5 :162.
    PubMed ID: 24917882
  • Ye Z, Vasco DA, Carter TC, Brilliant MH, Schrodi SJ, Shukla SK. (2014 May). Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections. Front Genet. 5 :125.
    PubMed ID: 24847357
  • Mayer J, Kitchner T, Ye Z, Zhou Z, He M, Schrodi SJ, Hebbring SJ. (2014 December). Use of an electronic medical record to create the marshfield clinic twin/multiple birth cohort. Genet Epidemiol. 38(8):692-8.
    PubMed ID: 25250975
  • Hebbring S, Slager S, Epperla N, Mazza JJ, Ye Z, Zhou Z,...Schrodi SJ [including Vasco DA, Brilliant MH.] (2013 January). Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia. BLOOD. 121(1):237-8.
    PubMed ID: 23287625
  • Hebbring S, Schrodi SJ, Ye Z, Zhou Z, Page D, Brilliant MH. (2013 April). A PheWAS approach in studying HLA-DRB1*1501 GENES AND IMMUNITY. 14(3):187-91.
    PubMed ID: 23392276
  • Schrodi SJ. (2012). Genomics/Phenomics/Proteomics/Translational Research. In: Powell V, Acharya A, Din FM, Humberto M (Ed.), Integration of Medical and Dental Care and Patient Data. (pp. 252-268). New York, New York: Springer.
  • Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F,...Schrodi S. (2012 December). Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet. 44(12):1341-8.
    PubMed ID: 23143594
  • Duffin KC, Freeny IC, Schrodi SJ, Wong B, Feng BJ, Soltani-Arabshahi R,...Krueger GG. (2009 December). Association between IL13 polymorphisms and psoriatic arthritis is modified by smoking. J Invest Dermatol. 129(12):2777-83.
    PubMed ID: 19554022
  • Feng BJ, Sun LD, Soltani-Arabshahi R, Bowcock AM, Nair RP, Stuart P,...Goldgar DE. (2009 August). Multiple Loci within the major histocompatibility complex confer risk of psoriasis. PLoS Genet. 5(8):e1000606.
    PubMed ID: 19680446
  • Li Y, Liao W, Chang M, Schrodi SJ, Bui N, Catanese JJ,...Begovich AB. (2009 March). Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22. Invest Dermatol. 129(3):629-34.
    PubMed ID: 18923449
  • Nair RP, Duffin KC, Helms C, Ding J, Stuart P, Goldgar DE,...Collaborative Association Study of Psoriasis. (2009 February). Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. NATURE GENETICS. 41(2):199-204.
    PubMed ID: 19169254
  • Schrodi SJ. (2008 September). Genome-wide association scan in psoriasis: new insights into chronic inflammatory disease. Expert Rev Clin Immunol. 4(5):565-71.
    PubMed ID: 20476959
  • Garcia VE, Chang M, Brandon R, Li Y, Matsunami N, Callis-Duffin KP,...Schrodi SJ. (2008 September). Detailed genetic characterization of the interleukin-23 receptor in psoriasis. Genes Immun. 9(6):546-55.
    PubMed ID: 18650833
  • Chang M, Rowland CM, Garcia VE, Schrodi SJ, Catanese JJ, van der Helm-van Mil AH,...Begovich AB. (2008 June). A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2. PLoS Genet.. 4(6):e1000107.
    PubMed ID: 18648537
  • Li Y, Rowland CM, Xiromerisiou G, Lagier RJ, Schrodi SJ, Dradiotis E,...Hadjigeorgiou G. (2008 July). Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. PLoS One. 3(7):e2707.
    PubMed ID: 18628988
  • Li Y, Chang M, Schrodi SJ, Callis-Duffin KP, Matsunami N, Civello D,...Begovich AB. (2008 October). The 5q31 variants associated with psoriasis and Crohn's disease are distinct. Hum Mol Genet. 17(19):2978-85.
    PubMed ID: 18614543
  • Chang M, Saiki RK, Catanese JJ, Lew D, van der Helm-van Mil AH, Toes RE,...Begovich AB. (2008 June). The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis. Arthritis Rheum. 58(6):1877-81.
    PubMed ID: 18512797
  • Chang M, Li Y, Yan C, Callis-Duffin KP, Matsunami N, Garcia VE,...Schrodi SJ. (2008 March). Variants in the 5q31 cytokine gene cluster are associated with psoriasis. Genes Immun. 9(2):176-81.
    PubMed ID: 18075513
  • Kurreeman FA, Padyukov L, Marques RB, Schrodi SJ, Seddighzadeh M, Stoeken-Rijsbergen G,...Toes RE. (2007 September). A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis. PLoS Med. 4(9):e278.
    PubMed ID: 17880261
  • Begovich AB, Chang M, Schrodi SJ. (2007 September). Meta-analysis evidence of a differential risk of the FCRL3 -169T-->C polymorphism in white and East Asian rheumatoid arthritis patients. Arthritis Rheum. 56(9):3168-71.
    PubMed ID: 17763442
  • Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis-Duffin KP,...Begovich AB. (2007 February). A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 80(2):273-90.
    PubMed ID: 17236132
  • Schrodi SJ, Garcia VE, Rowland CM, Jones HB. (2007 February). Pairwise linkage disequilibrium under disease models. Eur J Hum Genet. 15(2):212-20.
    PubMed ID: 17106449
  • Schrodi SJ, Chang M, Garcia VE, Civello D, Jacobson A, van der Helm-van Mil AH,...Begovich AB. (2007). A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2. Celera Report.
  • Huang H, Shiffman ML, Cheung RC, Layden TJ, Friedman SL, Abar OT,...Wright TL. (2006 May). Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C. Gastroenterology. 130(6):1679-87.
    PubMed ID: 16697732
  • Li Y, Schrodi SJ, Rowland CM, Tacey K, Catanese JJ, Grupe A. (2006 October). Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease. Hum Mutat. 27(10):1017-23.
    PubMed ID: 16917932
  • Li Y, Rowland CM, Schrodi SJ, Laird W, Tacey K, Ross DA,...Grupe A. (2006 June). A case-control association study of the 12 single-nucleotide polymorphisms implicated in Parkinson disease by a recent genome scan. Am J Hum Genet. 78(6):1090-2; author reply 1092-4.
    PubMed ID: 16685663
  • Schrodi SJ. (2005). A probabilistic approach to large-scale association scans: a semi-Bayesian method to detect disease-predisposing alleles. Stat Appl Genet Mol Biol. 4(1):Article 31.
    PubMed ID: 16646850
  • Carlton VE, Hu X, Chokkalingam AP, Schrodi SJ, Brandon R, Alexander HR,...Begovich AB. (2005 October). PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis. Am J Hum Genet. 77(4):567-81.
    PubMed ID: 16175503
  • Li Y, Tacey K, Doil L, van Luchene R, Garcia VE, Rowland CM,...Grupe A. (2004 August). Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study. Neurosci Lett. 366(3):268-71.
    PubMed ID: 15288432
  • Hu X, Schrodi SJ, Ross DA, Cargill M. (2004). Selecting tagging SNPs for association studies using power calculations from genotype data. Hum Hered. 57(3):156-70.
    PubMed ID: 15297809
  • Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, Alexander HR,...Gregersen PK. (2004 August). A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet. 75(2):330-7.
    PubMed ID: 15208781
  • Li Y, Nowotny P, Holmans P, Smemo S, Kauwe JS, Hinrichs AL,...Grupe A. (2004 November). Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. Proc Natl Acad Sci U S A. 101(44):15688-93.
    PubMed ID: 15507493
  • Schrodi SJ. (2001). A modification to the standard model of haploid population genetics for small population sizes. Mathematical models in population genetics, molecular evolution and genomics. Ann Arbor, MI:: UMI dissertation services;.
  • Schrodi SJ. (2001). Substitution variability under neutrality. A modification to the standard model of haploid population genetics for small population sizes. Ann Arbor, MI:: UMI dissertation services;.
  • Schrodi SJ. (2001). Increasing dispersion index for mammalian sequences. A modification to the standard model of haploid population genetics for small population sizes. Ann Arbor, MI:: UMI dissertation services;.