• Michael McManus MD

  • Physician - Pediatrics - Hematology/Oncology

    • Marshfield - Peds-Oncology
    • 1000 North Oak Avenue 1B1 Marshfield, WI 54449


Fellowship, Tumor Biology Postdoctoral Fellowship, Mayo Clinic - Mayo School of Health Services, Rochester, MN
Fellowship, Pediatric Oncology/Hematology Clinical Fellowship, Mayo Clinic - Mayo School of Medical School, Rochester, MN
Pediatrics Residency, Clinical Experience, University of Massachusetts Medical Center, Worcester, MA
Internship, Pediatrics, University of Massachusetts Medical School - Memorial Medical Center, Worcester, MA
MD, Medicine, Georgetown University, Washington, DC
BS, Biology/Molecular Biology, Boston College, Chestnut Hill, MA

Work Experience

2002 to Present:
Pediatric Oncologist, Marshfield Clinic Inc. - Marshfield Center, Marshfield, WI
2002 to Present:
Attending Physician, MCHS Hospitals Inc. d/b/a Marshfield Medical Center, Marshfield, WI
1995 to 2000:
Lecturer, Cell and Molecular Biology, Mayo Medical School, Rochester, MN
1992 to 2000:
Lecturer, Tumor Biology, Mayo Graduate School , Rochester, MN
1991 to 1996:
Coordinator and Instructor, Pediatric Hematology / Oncology Board Review, Rochester, MN

Board Certifications

1994 to 2022:
American Board of Pediatrics - Pediatric Hematology / Oncology (1994), Recertified
1988 to Present:
American Board of Pediatrics

Select Publications

  • Bunn HF, Shapiro R, McManus MJ, Garrick LM, McDonald MJ, Gallop PM, Gabbay KH. (1979 May). Structural heterogeneity of human hemoglobin A due to nonenzymatic glycosylation. J Biol Chem. 254(10):3892-3898.
    PubMed ID: 438166
  • Shapiro R, McManus MJ, Garrick LM, McDonald MJ, Bunn HF. (1979 April). Nonenzymatic glycosylation of human hemoglobin at multiple sites. Metabolism. 28(4 Suppl 1):427-430.
    PubMed ID: 122295
  • Shapiro R, McManus MJ, Zalut C, Bunn HF. (1980 April). Sites of nonenzymatic glycosylation of human hemoglobin A. J Biol Chem. 255(7):3120-3127.
    PubMed ID: 7358733
  • Garrick LM, McDonald MJ, Shapiro R, Bleichman M, McManus MJ, Bunn HF. (1980 May). Structural analysis of the minor human hemoglobin components: Hb AIa1, Hb AIa2 and Hb AIb. Eur J Biochem. 106(2):353-359.
    PubMed ID: 6772437
  • Leo ME, McManus MJ, Strawbridge LR, Kramer SA. (1992 July). Bilateral primary neuroblastomas in the inguinal canal. J Urol. 148(1):135-137.
    PubMed ID: 1613855
  • McManus MJ, Connolly DC, Maihle NJ. (1995 June). Tissue- and transformation-specific phosphotyrosyl proteins in v-erbB-transformed cells. J Virol. 69(6):3631-3638.
    PubMed ID: 7745711
  • O'Marcaigh AS, Johnson CM, Smithson WA, Patterson MC, Widemann BC, Adamson PC, McManus MJ. (1996 February). Successful treatment of intrathecal methotrexate overdose by using ventriculolumbar perfusion and intrathecal instillation of carboxypeptidase G2. Mayo Clin Proc. 71(2):161-165.
    PubMed ID: 8577190
  • Gill JS, Connolly DC, McManus MJ, Maihle NJ, Windebank AJ. (1996 March). Suramin induces phosphorylation of the high-affinity nerve growth factor receptor in PC12 cells and dorsal root ganglion neurons. J Neurochem. 66(3):963-972.
    PubMed ID: 8769855
  • McManus MJ, Hutt PJ, Maihle NJ. (1997 July). Phosphotyrosyl proteins in childhood rhabdomyosarcomas: phosphorylation of catenins and components of the insulin-like growth factor type I receptor signaling cascade. J Pediatr Hematol Oncol. 19(4):319-326.
    PubMed ID: 9256831
  • McManus MJ, Lingle WL, Salisbury JL, Maihle NJ. (1997 October). A transformation-associated complex involving tyrosine kinase signal adapter proteins and caldesmon links v-erbB signaling to actin stress fiber disassembly. Proc Natl Acad Sci USA. 94(21):11351-11356.
    PubMed ID: 9326613
  • Wang Z, Danielsen AJ, Maihle NJ, McManus MJ. (1999 November). Tyrosine phosphorylation of caldesmon is required for binding to the Shc.Grb2 complex. J Biol Chem. 274(47):33807-33813.
    PubMed ID: 10559276
  • McManus MJ, Boerner JL, Danielsen AJ, Wang Z, Matsumura F, Maihle NJ. (2000 November). An oncogenic epidermal growth factor receptor signals via a p21-activated kinase-caldesmon-myosin phosphotyrosine complex. J Biol Chem. 275(45):35328-35334.
    PubMed ID: 10954714
  • Boerner JL, McManus MJ, Martin GS, Maihle NJ. (2000 March). Ras-independent oncogenic transformation by an EGF-receptor mutant. J Cell Sci. 113(Pt 6):935-942.
    PubMed ID: 10683142
  • Boerner JL, Danielsen AJ, McManus MJ, Maihle NJ. (2001 February). Activation of Rho is required for ligand-independent oncogenic signaling by a mutant epidermal growth factor receptor. J Biol Chem. 276(5):3691-3695; Epub 2000 Nov 10.
    PubMed ID: 11110781
  • Joshi D, Nickerson HJ, McManus MJ. (2004 November). Hydrops fetalis caused by homozygous alpha-Thalassemia and Rh antigen alloimmunization. Report of a survivor and literature review. Clin Med Res. 2(4):228-232.
    PubMed ID: 15931362
  • Mitchell ME, McManus MJ, Dietz JC, Camitta BM, Szabo S, Havens P. (2010 April). Absidia corymbifera endocarditis: survival after treatment of disseminated mucormycosis with radical resection of tricuspid valve and right ventricular free wall. J Thorac Cardiovasc Surg. 139(4):e71-2.
    PubMed ID: 20304127