Shicheng Guo PhD
Center for Precision Medicine Research
1000 North Oak Ave. MLR Marshfield, WI 54449
- 2009 to 2015:
- PhD, Human Genetics, Fudan University, Shanghai
- 2005 to 2009:
- BS, Biotechnology, Northeast Agricultural University, Harbin
- 2015 to 2017:
- Postdoc, Department of Bioengineering, University of California, San Diego
- 2013 to 2014:
- Research Assistant, University of Texas Health Science Center at Houston, Houston
- 2012 to 2013:
- Visiting Student, University of Texas Health Science Center at Houston, Houston
- 2011 to 2012:
- Research Assistant, CAS-MPG Partner Institute for Computational Biology, Shanghai
- 2011 to 2012:
- Research Assistant, Institute of Rheumatology, Immunology and Allergy, Shanghai
Dr. Shicheng Guo received his Ph.D. degree in Fudan University under Prof. Li Jin, Prof. Jiucun Wang and Prof. Momiao Xiong. After the post-doctoral training at University of Texas Health Science Center at Houston (UT Health) and University of California, San Diego (UCSD), Dr. Guo joined Dr. Steven Schrodi’s lab at Center for Precision Medicine Research at the Marshfield Clinic Research Institute. Dr. Guo made series contribution on Human PBMC methylome, Silk methylome and tissue-of-origin mapping by cell-free circulating DNA methylation. Now, He is focusing on genetic epidemiology and the diagnostic and prognostic roles of epigenetic variations in human complex disease, especially human autoimmune disease and cancer. In the Marshfield Clinic, Dr. Guo will make full use of his bioinformatics, big data analysis and text mining skills to valuable Marshfield Personalize Medicine Research Project dataset (including 20,000 Exome-chip data and comprehensive clinical and epidemiological information) and Roadmap, Blueprint, Encode project to identify disease susceptibility genes and epigenetic markers for early diagnosis or real-time prognosis surveillance.
1. Interaction between Genetics and Epigenetics in Precision Medicine.
2. Epigenetic biomarker for cancer and autoimmnue diseases.
3. Novel Genetic Suscepitibility Genes for Rheumatoid Arthritis, Systemic Sclerosis, Ankylosing Spondylitis.
4. Pharmacogenomics for Rheumatoid Arthritis, Systemic Sclerosis, Ankylosing Spondylitis.
5. Drug Response, Resistance and Persistence based on pharmaco-genomics (PGx) and pharmaco-epigenomics (PeGx)
6. Deep learning in cancer and autoimmnue diseases diagnsotic and prognostic prediction and machanism discovery.
Guo S, Jiang S, Epperla N, Ma Y, Maadooliat M, Ye Z,...Schrodi SJ [including Olson B, Kitchner T, Joyce J, Strenn R, Mazza JJ, Meece JK.] A gene-based recessive diplotype exome scan discovers FGF6, a novel hepcidin-regulating iron metabolism gene. BLOOD. 2019 April 25; 133(17):1888-1898. doi: doi: 10.1182/blood-2018-10-879585.
PubMed ID: 30814063
Guo S, Liu J, Jiang T, Lee D, Wang R, Zhou X,...He D [including Schrodi SJ.] (5R)-5-Hydroxytriptolide (LLDT-8) induces substantial epigenetic mediated immune response network changes in fibroblast-like synoviocytes from rheumatoid arthritis patients. Sci Rep. 2019 August 1; 9(1):11155. PMCID: PMC6671973.
PubMed ID: 31371761
Zhou X, Li H, Guo S, Wang J, Shi C, Espitia M,...Mayes MD. Associations of Multiple NOTCH4 Exonic Variants with Systemic Sclerosis. [published online ahead of print 2018 November 15]. J Rheumatol.
PubMed ID: 30442821
Xu XH, Bao Y, Wang X, Yan F, Guo S, Ma Y,...Wang J. Hypoxic-stabilized EPAS1 proteins transactivate DNMT1 and cause promoter hypermethylation and transcription inhibition of EPAS1 in non-small cell lung cancer. [published online ahead of print 2018 June 19]. FASEB J. :fj201700715.
PubMed ID: 29920222
Wang C, Pu W, Zhao D, Zhou Y, Lu T, Chen S,...Wang M [including Guo S.] Identification of Hyper-Methylated Tumor Suppressor Genes-Based Diagnostic Panel for Esophageal Squamous Cell Carcinoma (ESCC) in a Chinese Han Population. Front Genet. 2018 September 5; 9 :356.
PubMed ID: 30233644
Jiang D, He Z, Wang C, Zhou Y, Li F, Pu W,...Wang M [including Guo S.] Epigenetic silencing of ZNF132 mediated by methylation-sensitive Sp1 binding promotes cancer progression in esophageal squamous cell carcinoma. Cell Death Dis. 2018 December 18; 10(1):1.
PubMed ID: 30578410
He D, Liu J, Hai Y, Zhu Q, Shen Y, Guo S,...Zhou X. Increased DOT1L in synovial biopsies of patients with OA and RA. Clin Rheumatol. 2018 May; 37(5):1327-1332.
PubMed ID: 29234911
Ding W, Pu W, Wang L, Jiang S, Zhou X, Tu W,...Wang J [including Guo S.] Genome-Wide DNA Methylation Analysis in Systemic Sclerosis Reveals Hypomethylation of IFN-Associated Genes in CD4+ and CD8+ T Cells. J Invest Dermatol. 2018 May; 138(5):1069-1077.
PubMed ID: 29248544
Pu W, Wang C, Chen S, Zhao D, Zhou Y, Ma Y,...Wang M [including Guo S.] (2017). Targeted bisulfite sequencing identified a panel of DNA methylation-based biomarkers for esophageal squamous cell carcinoma (ESCC). Clin Epigenetics. 9 :129.
PubMed ID: 29270239
Lei Y, Liu L, Zhang S, Guo S, Li X, Wang J,...Tao W. (2017 Nov 10). Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation. Mol. Cancer. 16(1):170.
PubMed ID: 29126425
Guo S, Zhu Q, Jiang T, Wang R, Shen Y, Zhu X,...He DY. (2017 May). Genome-wide DNA methylation patterns in CD4+ T cells from Chinese Han patients with rheumatoid arthritis. Mod Rheumatol. 27(3):441-447.
PubMed ID: 27585642
Guo S, Wang R, Jiang T, Bai F, Ding Q, Ma Y,...Tan L. (2017). Alterations and diagnosis potential of serum lipid profiles in rheumatoid arthritis patients. Int J Clin Exp Pathol.. :3503-3509.
Guo S, Diep D, Plongthongkum N, Fung HL, Zhang K, Zhang K. (2017 Apr). Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA. Nat. Genet.. 49(4):635-642.
PubMed ID: 28263317
Geng X, Pu W, Tan Y, Lu Z, Wang A, Tan L,...Chen X [including Guo S.] (2017 Jan 24). Quantitative assessment of the diagnostic role of FHIT promoter methylation in non-small cell lung cancer. Oncotarget. 8(4):6845-6856.
PubMed ID: 28036263
Fan L, Chen L, Ni X, Guo S, Zhou Y, Wang C,...Wang M. (2017). Genetic variant of miR-4293 rs12220909 is associated with susceptibility to non-small cell lung cancer in a Chinese Han population. PLoS ONE. 12(4):e0175666.
PubMed ID: 28410417
Zhang X, Zhang J, Wang R, Guo S, Zhang H, Ma Y,...Liu J. (2016 Jul). Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma. Oncol Lett. 12(1):670-674.
PubMed ID: 27347198
Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ,...Belmonte JC. (2016 Dec 1). In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Nature. 540(7631):144-149.
PubMed ID: 27851729
Shen F, Chen J, Guo S, Zhou Y, Zheng Y, Yang Y,...Wang M. (2016 Apr). Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population. Tumour Biol.. 37(4):4777-84.
PubMed ID: 26518769
Pu W, Geng X, Chen S, Tan L, Tan Y, Wang A,...Wang J. (2016). Aberrant methylation of CDH13 can be a diagnostic biomarker for lung adenocarcinoma. J Cancer. 7(15):2280-2289.
PubMed ID: 27994665
Guo S, Li Y, Wang Y, Chu H, Chen Y, Liu Q,...Wang J. (2016 May). Copy Number Variation of HLA-DQA1 and APOBEC3A/3B Contribute to the Susceptibility of Systemic Sclerosis in the Chinese Han Population. J. Rheumatol.. 43(5):880-6.
PubMed ID: 27036383
Zhang P, Wang J, Lu T, Wang X, Zheng Y, Guo S,...Wang M. (2015 Nov). miR-449b rs10061133 and miR-4293 rs12220909 polymorphisms are associated with decreased esophageal squamous cell carcinoma in a Chinese population. Tumour Biol.. 36(11):8789-95.
PubMed ID: 26055141
Wang J, Li J, Gu J, Yu J, Guo S, Zhu Y, Ye D. (2015 Nov). Abnormal methylation status of FBXW10 and SMPD3, and associations with clinical characteristics in clear cell renal cell carcinoma. Oncol Lett. 10(5):3073-3080.
PubMed ID: 26722292
Pan LL, Huang YM, Wang M, Zhuang XE, Luo DF, Guo SC,...Wang SY. (2015 Feb). Positional cloning and next-generation sequencing identified a TGM6 mutation in a large Chinese pedigree with acute myeloid leukaemia. Eur. J. Hum. Genet.. 23(2):218-23.
PubMed ID: 24755948
Lin N, Jiang J, Guo S, Xiong M. (2015). Functional Principal Component Analysis and Randomized Sparse Clustering Algorithm for Medical Image Analysis. PLoS ONE. 10(7):e0132945.
PubMed ID: 26196383
Jiang J, Lin N, Guo S, Chen J, Xiong M. (2015 Jun). Multiple functional linear model for association analysis of RNA-seq with imaging. Quant Biol. 3(2):90-102.
PubMed ID: 26753102
Guo S, Yan F, Xu J, Bao Y, Zhu J, Wang X,...Wang J. (2015). Identification and validation of the methylation biomarkers of non-small cell lung cancer (NSCLC). Clin Epigenetics. 7 :3.
PubMed ID: 25657825
Dong Z, Guo S, Yang Y, Wu J, Guan M, Zou H,...Wang J. (2015 May). Association between ABCG2 Q141K polymorphism and gout risk affected by ethnicity and gender: a systematic review and meta-analysis. Int J Rheum Dis. 18(4):382-91.
PubMed ID: 25639607
Zhao Y, Xue F, Sun J, Guo S, Zhang H, Qiu B,...Xia Q. (2014). Genome-wide methylation profiling of the different stages of hepatitis B virus-related hepatocellular carcinoma development in plasma cell-free DNA reveals potential biomarkers for early detection and high-risk monitoring of hepatocellular carcinoma. Clin Epigenetics. 6(1):30.
PubMed ID: 25859288
Zhao Y, Sun J, Zhang H, Guo S, Gu J, Wang W,...Yu J. (2014). High-frequency aberrantly methylated targets in pancreatic adenocarcinoma identified via global DNA methylation analysis using methylCap-seq. Clin Epigenetics. 6(1):18.
PubMed ID: 25276247
Xiao Q, Gao S, Luo H, Fan W, Guo S, Yao H,...Xiao Q. (2014 Jul). 9q33.3, a stress-related chromosome region, contributes to reducing lung squamous cell carcinoma risk. J Thorac Oncol. 9(7):1041-7.
PubMed ID: 24926550
Wang R, Zhang J, Ma Y, Chen L, Guo S, Zhang X,...Liu J. (2014 Nov). Association study of miR-149 rs2292832 and miR-608 rs4919510 and the risk of hepatocellular carcinoma in a large-scale population. Mol Med Rep. 10(5):2736-44.
PubMed ID: 25190221
Song X, Guo S, Chen Y, Yang C, Ji H, Zhang F,...Wang J. (2014 Apr). Association between HLA-DQA1 gene copy number polymorphisms and susceptibility to rheumatoid arthritis in Chinese Han population. J. Genet.. 93(1):215-8.
PubMed ID: 24840843
Jiang J, Lin N, Guo S, Chen J, Xiong M. (2014 Sep 13). Methods for Joint Imaging and RNA-seq Data Analysis. arXiv:1409.3899v1.
Huang L, Li Y, Guo S, Sun Y, Zhang C, Bai Y,...Li X. (2014 Apr 17). Different hereditary contribution of the CFH gene between polypoidal choroidal vasculopathy and age-related macular degeneration in Chinese Han people. Invest. Ophthalmol. Vis. Sci.. 55(4):2534-8.
PubMed ID: 24692129
He D, Wang J, Yi L, Guo X, Guo S, Guo G,...Zhou X. (2014). Association of the HLA-DRB1 with scleroderma in Chinese population. PLoS ONE. 9(9):e106939.
PubMed ID: 25184637
Guo S, Wang YL, Li Y, Jin L, Xiong M, Ji QH, Wang J. (2014 Jun). Significant SNPs have limited prediction ability for thyroid cancer. Cancer Med. 3(3):731-5.
PubMed ID: 24591304
Guo S, Tan L, Pu W, Wu J, Xu K, Wu J,...Wang J. (2014 Mar 24). Quantitative assessment of the diagnostic role of APC promoter methylation in non-small cell lung cancer. Clin Epigenetics. 6(1):5.
PubMed ID: 24661338
Wu L, Guo S, Yang D, Ma Y, Ji H, Chen Y,...Liu J. (2014 Feb). Copy number variations of HLA-DRB5 is associated with systemic lupus erythematosus risk in Chinese Han population. Acta Biochim. Biophys. Sin. (Shanghai). 46(2):155-60.
PubMed ID: 24366815
Zhao Y, Zhou H, Ma K, Sun J, Feng X, Geng J,...Lin Q. (2013 Apr). Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer. Oncol Lett. 5(4):1211-1218.
PubMed ID: 23599765
Wang YL, Feng SH, Guo SC, Wei WJ, Li DS, Wang Y,...Wang JC. (2013 Oct). Confirmation of papillary thyroid cancer susceptibility loci identified by genome-wide association studies of chromosomes 14q13, 9q22, 2q35 and 8p12 in a Chinese population. J. Med. Genet.. 50(10):689-95.
PubMed ID: 23847140
Wang X, Wang L, Guo S, Bao Y, Ma Y, Yan F,...Wang JC. (2013 Oct). Hypermethylation reduces expression of tumor-suppressor PLZF and regulates proliferation and apoptosis in non-small-cell lung cancers. FASEB J.. 27(10):4194-203.
PubMed ID: 23804241
Wang J, Yang Y, Guo S, Chen Y, Yang C, Ji H,...Zhou X. (2013 Dec). Association between copy number variations of HLA-DQA1 and ankylosing spondylitis in the Chinese Han population. Genes Immun.. 14(8):500-3.
PubMed ID: 24048351
Lin S, Pan L, Guo S, Wu J, Jin L, Wang JC, Wang S. (2013). Prognostic role of microRNA-181a/b in hematological malignancies: a meta-analysis. PLoS ONE. 8(3):e59532.
PubMed ID: 23533632
Zhao Y, Guo S, Sun J, Huang Z, Zhu T, Zhang H,...Yu J. (2012). Methylcap-seq reveals novel DNA methylation markers for the diagnosis and recurrence prediction of bladder cancer in a Chinese population. PLoS ONE. 7(4):e35175.
PubMed ID: 22529986
Wu J, Wu J, Zhou Y, Zou H, Guo S, Liu J,...Xu H. (2012 Dec). Quantitative assessment of the variation in IGF2BP2 gene and type 2 diabetes risk. Acta Diabetol. 49 Suppl 1 :S87-97.
PubMed ID: 22015911
Wu J, Liu J, Zhou Y, Ying J, Zou H, Guo S,...Wang JC. (2012 Jul 15). Predictive value of XRCC1 gene polymorphisms on platinum-based chemotherapy in advanced non-small cell lung cancer patients: a systematic review and meta-analysis. Clin. Cancer Res.. 18(14):3972-81.
PubMed ID: 22705987
He Y, Cui Y, Wang W, Gu J, Guo S, Ma K, Luo X. (2011 Sep). Hypomethylation of the hsa-miR-191 locus causes high expression of hsa-mir-191 and promotes the epithelial-to-mesenchymal transition in hepatocellular carcinoma. Neoplasia. 13(9):841-53.
PubMed ID: 21969817
Xiang H, Zhu J, Chen Q, Dai F, Li X, Li M,...Wang J. (2010 May). Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat. Biotechnol.. 28(5):516-20.
PubMed ID: 20436463
Li Y, Zhu J, Tian G, Li N, Li Q, Ye M,...Zhang X. (2010 Nov 9). The DNA Methylome of Human Peripheral Blood Mononuclear Cells. PLos Biology.