• Scott J Hebbring PhD

  • Research Scientist - Genetics


    • Center for Human Genetics
    • 1000 North Oak Ave. MLR Marshfield, WI 54449

Education


2012 to 2014:
Computation and Informatics in Biology and Medicine (CIBM) training program Research conducted under Dr. Murray Brilliant and Dr. David Page., University of Wisconsin Madison, Madison
2007 to 2012:
PhD, Ph.D. in Biochemistry and Molecular Biology. Research conducted under Dr. Richard Weinshilboum., Mayo Clinic Graduate School, Rochester
2007 to 2007:
Human Genome Analysis: Genetic Analysis of Multifactorial Disease, Wellcome Trust Institute
1996 to 2000:
BS, Bachelor of Science in Biochemistry and Molecular Biology, University of Wisconsin Eau Claire, Eau Claire

Work Experience


2017 to Present:
Research Scientist, Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield
2013 to 2017:
Associate Research Scientist, Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield
2012 to 2012:
Postdoctoral Fellow, Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield
2001 to 2007:
Senior Research Technologist, Experimental Pathology Laboratory, Mayo Clinic, Rochester
1999 to 2000:
Student Research Internship under Dr. Jon Scales, University of Wisconsin Eau Claire, Eau Claire
1998 to 1999:
Student Reseach Internship under Dr. Victoria Vander Noot, Sandia National Laboratory, Livermore

Statement


Dr. Hebbring is a Research Scientist in the Center for Human Genetics at Marshfield Clinic. He completed his doctoral training at Mayo Clinic with a focus on pharmacogenomics. Dr. Hebbring continued his training as a post-doctoral fellow in UW-Madison’s Computational and Informatics in Biology and Medicine (CIBM) training program. His current research is multidisciplinary that combines statistical genetics and medical informatics with molecular biology. The lab utilizes Marshfield Clinic’s extensive electronic health recorded and 20,000 Marshfield Clinic patients that make up a highly informative biobank. With these resources, the lab focuses on the genetic causes of human disease in both families and populations of unrelated individuals. The goal is to return genetic results to the patient and healthcare system to prevent, treat, and better understanding the biological etiologies of human disease.


Research Interests


Human Genetics

Select Publications


  • Carter TC, Hebbring SJ, Liu J, Mosley JD, Shaffer CM, Ivacic LC, Kopitzke S, Stefanski EL, Strenn R, Sundaram ME, Meece J, Brilliant MH, Ferdinands JM, Belongia EA. Pilot screening study of targeted genetic polymorphisms for association with seasonal influenza hospital admission. J. Med. Virol.. 2018 Mar;90(3):436-446.
    PubMed ID: 29053189
  • Huang X, Elston RC, Rosa GJ, Mayer J, Ye Z, Kitchner T, Brilliant MH, Page D, Hebbring SJ. Applying Family Analyses to Electronic Health Records to Facilitate Genetic Research. BIOINFORMATICS. 2018 Feb 15;34(4):635-642.
    PubMed ID: 28968884
  • Blue E, Louie TL, Chong JX, Hebbring SJ, Barnes KC, Rafaels NM, Knowles MR, Gibson RL, Bamshad MJ, Emond MJ. Variation in Cilia Protein Genes and Progression of Lung Disease in Cystic Fibrosis. Ann Am Thorac Soc.. 2018 Apr;15(4):440-448.
    PubMed ID: 29323929
  • Bastarache L, Hughey JJ, Hebbring S, Marlo J, Zhao W, Ho WT, Van Driest SL, McGregor TL, Mosley JD, Wells QS, Temple M, Ramirez AH, Carroll R, Osterman T, Edwards T, Ruderfer D, Velez Edwards DR, Hamid R, Cogan J, Glazer A, Wei WQ, Feng Q, Brilliant M, Zhao ZJ, Denny JC. Phenotype risk scores identify patients with unrecognized Mendelian disease patterns. SCIENCE. 2018 Mar 16;359(6381):1233-1239.
    PubMed ID: 29590070
  • Karnes JH, Bastarache L, Shaffer CM, Gaudieri S, Xu Y, Glazer AM, Mosley JD, Zhao S, Raychaudhuri S, Mallal S, Ye Z, Mayer JG, Brilliant MH, Hebbring SJ, Roden DM, Phillips EJ, Denny JC. Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants. Sci Transl Med. 2017 May 10;9(389)
    PubMed ID: 28490672
  • Liu J, Zhao R, Ye Z, Frey AJ, Schriver ER, Snyder NW, Hebbring SJ. Relationship of SULT1A1 copy number variation with estrogen metabolism and human health. J. Steroid Biochem. Mol. Biol.. 2017 Nov 1;174 :169-75.
    PubMed ID: 28867356
  • Fritsche LG, Igl W, Bailey JN, Grassmann F, Sengupta S, Bragg-Gresham JL, Burdon KP, Hebbring SJ, Wen C, Gorski M, Kim IK, Cho D, Zack D, Souied E, Scholl HP, Bala E, Lee KE, Hunter DJ, Sardell RJ, Mitchell P, Merriam JE, Cipriani V, Hoffman JD, Schick T, Lechanteur YT, Guymer RH, Johnson MP, Jiang Y, Stanton CM, Buitendijk GH, Zhan X, Kwong AM, Boleda A, Brooks M, Gieser L, Ratnapriya R, Branham KE, Foerster JR, Heckenlively JR, Othman MI, Vote BJ, Liang HH, Souzeau E, McAllister IL, Isaacs T, Hall J, Lake S, Mackey DA, Constable IJ, Craig JE, Kitchner TE, Yang Z, Su Z, Luo H, Chen D, Ouyang H, Flagg K, Lin D, Mao G, Ferreyra H, Stark K, von Strachwitz CN, Wolf A, Brandl C, Rudolph G, Olden M, Morrison MA, Morgan DJ, Schu M, Ahn J, Silvestri G, Tsironi EE, Park KH, Farrer LA, Orlin A, Brucker A, Li M, A Curcio C, Mohand-Saïd S, Sahel JA, Audo I, Benchaboune M, Cree AJ, Rennie CA, Goverdhan SV, Grunin M, Hagbi-Levi S, Campochiaro P, Katsanis N, Holz FG, Blond F, Blanché H, Deleuze JF, Igo RP, Truitt B, Peachey NS, Meuer SM, Myers CE, Moore EL, Klein R, Hauser MA, Postel EA, Courtenay MD, Schwartz SG, Kovach JL, Scott WK, Liew G, Tan AG, Gopinath B, Merriam JC, Smith RT, Khan JC, Shahid H, Moore AT, McGrath JA, Laux R, Brantley MA, Agarwal A, Ersoy L, Caramoy A, Langmann T, Saksens NT, de Jong EK, Hoyng CB, Cain MS, Richardson AJ, Martin TM, Blangero J, Weeks DE, Dhillon B, van Duijn CM, Doheny KF, Romm J, Klaver CC, Hayward C, Gorin MB, Klein ML, Baird PN, den Hollander AI, Fauser S, Yates JR, Allikmets R, Wang JJ, Schaumberg DA, Klein BE, Hagstrom SA, Chowers I, Lotery AJ, Léveillard T, Zhang K, Brilliant MH, Hewitt AW, Swaroop A, Chew EY, Pericak-Vance MA, DeAngelis M, Stambolian D, Haines JL, Iyengar SK, Weber BH, Abecasis GR, Heid IM. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet. 2016 Feb 21;48(2):134-43..
    PubMed ID: 26691988
  • Simonti CN, Vernot B, Bastarache L, Bottinger E, Carrell DS, Chisholm RL, Crosslin DR, Hebbring SJ, Jarvik GP, Kullo IJ, Li R, Pathak J, Ritchie MD, Roden DM, Verma SS, Tromp G, Prato JD, Bush WS, Akey JM, Denny JC, Capra JA. The phenotypic legacy of admixture between modern humans and Neandertals. SCIENCE. 2016 Feb 12;351(6274):737-41.
    PubMed ID: 26912863
  • Mosley JD, Witte JS, Larkin EK, Bastarache L, Shaffer CM, Karnes JH, Stein CM, Phillips E, Hebbring SJ, Brilliant MH, Mayer J, Ye Z, Roden DM, Denny JC. Identifying genetically driven clinical phenotypes using linear mixed models. Nat Commun. 2016 Apr 25;7 :11433.
    PubMed ID: 27109359
  • Maadooliat M, Bansal NK, Upadhya J, Farazi MR, Li X, He MM, Hebbring SJ, Ye Z, Schrodi SJ. The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem. Front Genet. 2016 Dec 12;7 :217.
    PubMed ID: 28018425
  • Verma A, Verma SS, Pendergrass SA, Crawford DC, Crosslin DR, Kuivaniemi H, Bush WS, Bradford Y, Kullo I, Bielinski SJ, Li R, Denny JC, Peissig P, Hebbring S, De Andrade M, Ritchie MD, Tromp G. eMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants. BMC Med Genomics. 2016;9 Suppl 1 :32.
    PubMed ID: 27535653
  • Kim T, Havighurst T, Kim K, Hebbring SJ, Ye Z, Aylward J, Keles S, Xu YG, Spiegelman VS. RNA-Binding Protein IGF2BP1 in Cutaneous Squamous Cell Carcinoma. J Invest Dermatol. 2016 Nov 14;
    PubMed ID: 27856289
  • Brilliant MH, Vaziri K, Connor TB, Schwartz SG, Carroll JJ, McCarty CA, Schrodi SJ, Hebbring SJ, Kishor KS, Flynn HW, Moshfeghi AA, Moshfeghi DM, Fini ME, McKay BS. Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration. Am J Med. 2016 Mar;129(3):292-8.
    PubMed ID: 26524704
  • Liu J, Ye Z, Mayer JG, Hoch BA, Green C, Rolak L, Cold C, Khor SS, Zheng X, Miyagawa T, Tokunaga K, Brilliant MH, Hebbring SJ. Phenome-wide association study maps new diseases to the human major histocompatibility complex region. J Med Genet. 2016 Oct;53(10):681-9.
    PubMed ID: 27287392
  • Ye Z, Mayer JG, Ivacic LC, Zhou Z, He M, Schrodi SJ, Page D, Brilliant MH, Hebbring S. Phenome-wide association studies (PheWASs) for functional variants. Eur J Hum Genet. 2015 Apr;23(4):523-9.
    PubMed ID: 25074467
  • He M, Person TN, Hebbring S, Heinzen E, Ye Z, Schrodi SJ, McPherson EW, Lin S, Peissig PL, Brilliant MH, O'Rawe J, Robinson RJ, Lyon GJ, Wang K. SeqHBase: a big data toolset for family based sequencing data analysis. JOURNAL OF MEDICAL GENETICS. 2015 Apr;52(4):282-8.
    PubMed ID: 25587064
  • Zhang W, Yu Y, Hertwig F, Thierry-Mieg J, Zhang W, Thierry-Mieg D, Wang J, Furlanello C, Devanarayan V, Cheng J, Deng Y, Hero B, Hong H, Jia M, Li L, Lin SM, Nikolsky Y, Oberthuer A, Qing T, Su Z, Volland R, Wang C, Wang MD, Ai J, Albanese D, Asgharzadeh S, Avigad S, Bao W, Bessarabova M, Brilliant MH, Brors B, Chierici M, Chu TM, Zhang J, Grundy RG, He MM, Hebbring S, Kaufman HL, Lababidi S, Lancashire LJ, Li Y, Lu XX, Luo H, Ma X, Ning B, Noguera R, Peifer M, Phan JH, Roels F, Rosswog C, Shao S, Shen J, Theissen J, Tonini GP, Vandesompele J, Wu PY, Xiao W, Xu J, Xu W, Xuan J, Yang Y, Ye Z, Dong Z, Zhang KK, Yin Y, Zhao C, Zheng Y, Wolfinger RD, Shi T, Malkas LH, Berthold F, Wang J, Tong W, Shi L, Peng Z, Fischer M. Comparison of RNA-seq and microarray-based models for clinical endpoint prediction. Genome Biol.. 2015;16 :133.
    PubMed ID: 26109056
  • Van Driest SL, McGregor TL, Velez Edwards DR, Saville BR, Kitchner TE, Hebbring SJ, Brilliant M, Jouni H, Kullo IJ, Creech CB, Kannankeril PJ, Vear SI, Brothers KB, Bowton EA, Shaffer CM, Patel N, Delaney JT, Bradford Y, Wilson S, Olson LM, Crawford DC, Potts AL, Ho RH, Roden DM, Denny JC. Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy. PLoS One. 2015;10(6):e0127791.
    PubMed ID: 26030142
  • Rastegar-Mojarad M, Ye Z, Kolesar JM, Hebbring SJ, Lin SM. Opportunities for drug repositioning from phenome-wide association studies. Nat. Biotechnol.. 2015 Apr;33(4):342-5.
    PubMed ID: 25850054
  • Hebbring SJ, Rastegar-Mojarad M, Ye Z, Mayer J, Jacobson C, Lin S. Application of clinical text data for phenome-wide association studies (PheWASs). BIOINFORMATICS. 2015 Jun 15;31(12):1981-7.
    PubMed ID: 25657332
  • Hebbring S. The Challenges, Advantages, and Future of Phenome-Wide Association Studies. IMMUNOLOGY. 2014 Feb;141(2):157-65.
    PubMed ID: 24147732
  • Cronin RM, Field JR, Bradford Y, Shaffer CM, Carroll RJ, Mosley JD, Bastarache L, Edwards TL, Hebbring SJ, Lin S, Hindorff LA, Crane PK, Pendergrass SA, Ritchie MD, Crawford DC, Pathak J, Bielinski SJ, Carrell DS, Crosslin DR, Ledbetter DH, Carey DJ, Tromp G, Williams MS, Larson EB, Jarvik GP, Peissig PL, Brilliant MH, McCarty CA, Chute CG, Kullo IJ, Bottinger E, Chisholm R, Smith ME, Roden DM, Denny JC. Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index. Front Genet. 2014 Aug 5;5 :250.
    PubMed ID: 25177340
  • Mayer J, Kitchner T, Ye Z, Zhou Z, He M, Schrodi SJ, Hebbring SJ. Use of an electronic medical record to create the marshfield clinic twin/multiple birth cohort. Genet Epidemiol. 2014 Dec;38(8):692-8.
    PubMed ID: 25250975
  • Barrie ES, Weinshenker D, Verma A, Pendergrass SA, Lange LA, Ritchie MD, Wilson JG, Kuivaniemi H, Tromp G, Carey DJ, Gerhard GS, Brilliant MH, Hebbring SJ, Cubells JF, Pinsonneault JK, Norman GJ, Sadee W. Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity. Circ Res. 2014 Dec 5;115(12):1017-25.
    PubMed ID: 25326128
  • Hebbring S, Slager S, Epperla N, Mazza JJ, Ye Z, Zhou Z, Achenbach S, Vasco DA, Call T, Rabe K, Kay NE, Caporaso NE, Lanasa M, Camp N, Strom S, Goldin L, Cerhan J, Brilliant MH, Schrodi SJ. Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia. BLOOD. 2013 Jan;121(1):237-8.
    PubMed ID: 23287625
  • Hebbring S, Schrodi SJ, Ye Z, Zhou Z, Page D, Brilliant MH. A PheWAS approach in studying HLA-DRB1*1501 GENES AND IMMUNITY. 2013 Apr;14(3):187-91.
    PubMed ID: 23392276
  • Ji Y, Biernacka JM, Hebbring S, Chai Y, Jenkins GD, Batzler A, Snyder KA, Drews MS, Desta Z, Flockhart D, Mushiroda T, Kubo M, Nakamura Y, Kamatani N, Schaid D, Weinshilboum RM, Mrazek DA. Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics. Pharmacogenomics J.. 2013 Oct;13(5):456-63.
    PubMed ID: 22907730
  • Haas DM, Dantzer J, Lehmann AS, Philips S, Skaar TC, McCormick CL, Hebbring SJ, Jung J, Li L. The impact of glucocorticoid polymorphisms on markers of neonatal respiratory disease after antenatal betamethasone administration. Am J Obstet Gynecol. 2013 Mar;208(3):215.e1-6.
    PubMed ID: 23295978
  • Ellsworth KA, Moon I, Eckloff BW, Fridley BL, Jenkins GD, Batzler A, Biernacka JM, Abo R, Brisbin A, Ji Y, Hebbring S, Wieben ED, Mrazek DA, Weinshilboum RM, Wang L. FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder. Pharmacogenet Genomics. 2013 Mar;23(3):156-66.
    PubMed ID: 23324805
  • Hebbring S, Chai Y, Ji Y, Abo R, Jenkins G, Fridley B, Zhang J, Eckloff B, Wieben E, Weinshilboum RM. Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization. JOURNAL OF NEUROCHEMISTRY. 2012 Mar;120(6):881-90.
    PubMed ID: 22220685
  • Abo R, Hebbring S, Ji Y, Zhu H, Zeng Z, Batzler A, Jenkins G, Biernacka J, Snyder K, Drews M, Fiehn O, Fridley B, Schaid D, Kamatani N, Nakamura Y, Kubo M, Mushiroda T, Kaddurah-Daouk R, Mrazek D, Weinshilboum RM. Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics. Pharmacogenetics and Genomics. 2012 Apr;22(4):247-253.
    PubMed ID: 22322242
  • Lu L, Cancel-Tassin G, Valeri A, Cussenot O, Lange E, Cooney K, Farnham J, Camp N, Cannon-Albright L, Tammela T, Schleutker J, Hoegel J, Herkommer K, Maier C, Vogel W, Wiklund F, Emanuelsson M, Gronberg H, Wiley K, Isaacs S, Walsh P, Helfand B, Kan D, Catalona WJ, Stanford J, FitzGerald L, Johanneson B, Deutsch K, McIntosh L, Ostrander E, Thibodeau SN, McDonnell S, Hebbring S, Schaid DJ, Whittemore A, Oakley-Girvan I, Hsieh C, Powell I, Bailey-Wilson J, Cropp C, Simpson C, Carpten J, Seminara D, Zheng S, Xu J, Giles GG, Severi G, Hopper JL, English DR, Foulkes W, Maehle L, Moller P, Badzioch M, Edwards S, Guy M, Eeles R, Easton D, Isaacs W, International Consortium for Prostate Cancer Genetics. Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG PROSTATE. 2012 Mar;72(4):410-26.
    PubMed ID: 21748754
  • Bailey-Wilson J, Childs E, Cropp C, Schaid DJ, Xu J, Camp N, Cannon-Albright L, Farnham J, George A, Powell I, Carpten J, Giles GG, Hopper JL, Severi G, English DR, Foulkes W, Maehle L, Moller P, Eeles R, Easton D, Guy M, Edwards S, Badzioch M, Whittemore A, Oakley-Girvan I, Hsieh C, Dimitrov L, Standford J, Karyadi D, Deutsch K, McIntosh L, Ostrander E, Wiley K, Isaacs S, Walsh P, Thibodeau SN, McDonnell S, Hebbring S, Lange E, Cooney K, Tammela T, Schleutker J, Maier C, Bochum S, Hoegel J, Gronberg H, Wiklund F, Emanuelsson M, Cancel-Tassin G, Valeri A, Cussenot O, Isaacs W, International Consortium for Prostate Cancer Genetics. Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families. BMC Medical Genetics. 2012 Jun;13(46)
    PubMed ID: 22712434
  • Ji Y, Nordgren KK, Chai Y, Hebbring SJ, Jenkins GD, Abo RP, Peng Y, Pelleymounter LL, Moon I, Eckloff BW, Chai X, Zhang J, Fridley BL, Yee VC, Wieben ED, Weinshilboum RM. Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation. Drug Metab. Dispos.. 2012 Oct;40(10):1984-92.
    PubMed ID: 22807109
  • Ji Y, Hebbring S, Zhu H, Jenkins G, Biernacka J, Snyder K, Drews M, Fiehn O, Zeng Z, Schaid D, Mrazek D, Kaddurah-Daouk R, Weinshilboum RM. Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics. CLINICAL PHARMACOLOGY & THERAPEUTICS. 2011 Jan;89(1):97-104.
    PubMed ID: 21107318
  • Feng Q, Kalari K, Fridley B, Jenkins G, Ji Y, Abo R, Hebbring S, Zhang J, Nye M, Leeder J, Weinshilboum RM. Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation. MOLECULAR GENETICS AND METABOLISM. 2011 Feb;102(2):126-33.
    PubMed ID: 21093336
  • Kalari K, Hebbring S, Chai H, Li L, Kocher J, Wang L, Weinshilboum RM. Copy number variation and cytidine analogue cytotoxicity: a genome-wide association approach. BMC GENOMICS. 2010 Jun;11 :357.
    PubMed ID: 20525348
  • Christensen G, Baffoe-Bonnie A, George A, Powell I, Bailey-Wilson J, Carpten J, Giles GG, Hopper JL, Severi G, English DR, Foulkes W, Maehle L, Moller P, Eeles R, Easton D, Badzioch M, Whittemore A, Oakley-Girvan I, Hsieh C, Dimitrov L, Xu J, Stanford J, Johanneson B, Deutsch K, McIntosh L, Ostrander E, Wiley K, Isaacs S, Walsh P, Isaacs W, Thibodeau SN, McDonnell S, Hebbring S, Schaid DJ, Lange E, Cooney K, Tammela T, Schleutker J, Paiss T, Maier C, Gronberg H, Wiklund F, Emanuelsson M, Farnham J, Cannon-Albright L, Camp N, International Consortium for Prostate Cancer Genetics. Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for Prostate Cancer Genetics using novel sumLINK and sumLOD analyses. PROSTATE. 2010 May;70(7):735-44.
    PubMed ID: 20333727
  • Fridley B, Jenkins G, Deyo-Svendsen M, Hebbring S, Freimuth R. Utilizing genotype imputation for the augmentation of sequence data. PLoS One. 2010 Jun;5(6):e11018.
    PubMed ID: 20543988
  • Wang L, McDonnell S, Hebbring S, Cunningham J, St Sauver J, Cerhan J, Isaya G, Schaid DJ, Thibodeau SN. Polymorphisms in mitochondrial genes and prostate cancer risk. Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3558-66.
    PubMed ID: 19064571
  • Hebbring S, Moyer A, Weinshilboum RM. Sulfotransferase gene copy number variation: pharmacogenetics and function. CYTOGENETIC AND GENOME RESEARCH. 2008;123(1-4):205-10.
    PubMed ID: 19287157
  • Johanneson B, McDonnell S, Karyadi D, Hebbring S, Wang L, Deutsch K, McIntosh L, Kwon E, Suuriniemi M, Standford J, Schaid DJ, Ostrander E, Thibodeau SN. Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb. HUMAN GENETICS. 2008 Feb;123(1):65-75.
    PubMed ID: 18066601
  • Cunningham J, Hebbring S, McDonnell S, Cicek M, Christensen G, Wang L, Jacobsen SJ, Cerhan J, Blute M, Schaid DJ, Thibodeau SN. Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer. Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):969-78.
    PubMed ID: 17507624
  • Wang L, McDonnell S, Slusser JP, Hebbring S, Cunningham J, Jacobsen SJ, Cerhan J, Blute M, Schaid DJ, Thibodeau SN. Two common chromosome 8q24 variants are associated with increased risk for prostate cancer. CANCER RESEARCH. 2007 Apr;67(7):2944-50.
    PubMed ID: 17409399
  • Moyer A, Salavaggione O, Hebbring S, Moon I, Hildebrandt M, Eckloff B, Schaid DJ, Wieben E, Weinshilboum RM. Glutathione S-transferase T1 and M1: gene sequence variation and functional genomics. CLINICAL CANCER RESEARCH. 2007 Dec;13(23):7207-16.
    PubMed ID: 18056202
  • Hebbring S, Adjei A, Baer J, Jenkins G, Zhang J, Cunningham J, Schaid DJ, Weinshilboum RM, Thibodeau SN. Human SULT1A1 gene: copy number differences and functional implications. HUMAN MOLECULAR GENETICS. 2007 Mar;16(5):463-70.
    PubMed ID: 17189289
  • Camp N, Cannon-Albright L, Farnham J, Baffoe-Bonnie A, George A, Powell I, Bailey-Wilson J, Carpten J, Giles GG, Hopper JL, Severi G, English DR, Foulkes W, Maehle L, Moller P, Eeles R, Easton D, Badzioch M, Whittemore A, Oakley-Girvan I, Hsieh C, Dimitrov L, Xu J, Standford J, Johanneson B, Deutsch K, McIntosh L, Ostrander E, Wiley K, Isaacs S, Walsh P, Thibodeau SN, McDonnell S, Hebbring S, Schaid DJ, Lange E, Cooney K, Tammela T, Schleutker J, Paiss T, Maier C, Gronberg H, Wiklund F, Emanuelsson M, Isaacs W, International Consortium for Prostate Cancer Genetics. Compelling evidence for a prostate cancer gene at 22q12.3 by the International Consortium for Prostate Cancer Genetics. HUMAN MOLECULAR GENETICS. 2007 Jun;16(11):1271-8.
    PubMed ID: 17478474
  • Hebbring S, Fredriksson H, White K, Maier C, Ewing C, McDonnell S, Jacobsen SJ, Cerhan J, Schaid DJ, Ikonen T, Autio V, Tammela T, Herkommer K, Paiss T, Vogel W, Gielzak M, Sauvageot J, Schleutker J, Cooney K, Isaacs W, Thibodeau SN. Role of the Nijmegen breakage syndrome 1 gene in familial and sporadic prostate cancer. Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):935-8.
    PubMed ID: 16702373
  • Schaid DJ, McDonnell S, Zarfas K, Cunningham J, Hebbring S, Thibodeau SN, Eeles R, Easton DF, Foulkes W, Simard J, Giles GG, Hopper JL, Mahle L, Moller P, Badzioch M, Bishop D, Evans C, Edwards S, Meitz J, Bullock S, Hope Q, Guy M, Hsieh C, Halpern J, Balise R, Oakley-Girvan I, Whittemore A, Xu J, Dimitrov L, Chang B, Adams T, Turner A, Meyers DA, Friedrichsen D, Deutsch K, Kolb S, Janer M, Hood L, Ostrander E, Standford J, Ewing C, Gielzak M, Isaacs S, Walsh P, Wiley K, Isaacs W, Lange E, Ho L, Beebe-Dimmer J, Wood D, Cooney K, Seminara D, Ikonen T, Baffoe-Bonnie A, Fredriksson H, Matikainen M, Tammela T, Bailey-Wilson J, Schleutker J, Maier C, Herkommer K, Hoegel J, Vogel W, Paiss T, Wiklund F, Emanuelsson M, Stenman E, Jonsson B, Gronberg H, Camp N, Farnham J, Cannon-Albright L, Catalona WJ, Suarez B, Roehl K. Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics. HUMAN GENETICS. 2006 Nov;120(4):471-85.
    PubMed ID: 16932970
  • Roberts R, Bergstralh EJ, Farmer S, Jacobson D, Hebbring S, Cunningham J, Thibodeau SN, Lieber MM, Jacobsen SJ. Polymorphisms in genes involved in sex hormone metabolism may increase risk of benign prostatic hyperplasia. PROSTATE. 2006 Mar;66(4):392-404.
    PubMed ID: 16302261
  • Mullan R, Bergstralh EJ, Farmer S, Jacobson D, Hebbring S, Cunningham J, Thibodeau SN, Lieber MM, Jacobsen SJ, Roberts R. Growth factor, cytokine, and vitamin D receptor polymorphisms and risk of benign prostatic hyperplasia in a community-based cohort of men. UROLOGY. 2006 Feb;67(2):300-5.
    PubMed ID: 16461080
  • Xu J, Dimitrov L, Chang B, Adams T, Turner A, Meyers DA, Eeles R, Easton DF, Foulkes W, Simard J, Giles GG, Hopper JL, Mahle L, Moller P, Bishop T, Evans C, Edwards S, Meitz J, Bullock S, Hope Q, Hsieh C, Halpern J, Balise R, Oakley-Girvan I, Whittemore A, Ewing C, Gielzak M, Isaacs S, Walsh P, Wiley K, Isaacs W, Thibodeau SN, McDonnell S, Cunningham J, Zarfas K, Hebbring S, Schaid DJ, Friedrichsen D, Deutsch K, Kolb S, Badzioch M, Jarvik G, Janer M, Hood L, Ostrander E, Stanford J, Lange E, Beebe-Dimmer J, Mohai C, Cooney K, Ikonen T, Baffoe-Bonnie A, Fredriksson H, Matikainen M, Tammela T, Bailey-Wilson J, Schleutker J, Maier C, Herkommer K, Hoegel J, Vogel W, Paiss T, Wiklund F, Emanuelsson M, Stenman E, Jonsson B, Gronberg H, Camp N, Farnham J, Cannon-Albright L, Seminara D, ACTANE Consortium. A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics. AMERICAN JOURNAL OF HUMAN GENETICS. 2005 Aug;77(2):219-29.
    PubMed ID: 15988677
  • Schaid DJ, McDonnell S, Hebbring S, Cunningham J, Thibodeau SN. Nonparametric tests of association of multiple genes with human disease. AMERICAN JOURNAL OF HUMAN GENETICS. 2005 May;76(5):780-93.
    PubMed ID: 15786018
  • Narla G, Difeo A, Reeves H, Schaid DJ, Hirshfeld J, Hod E, Katz AS, Isaacs W, Hebbring S, Komiya A, McDonnell S, Wiley K, Jacobsen SJ, Isaacs S, Walsh P, Zheng S, Chang B, Friedrichsen D, Stanford J, Ostrander E, Chinnaiyan A, Rubin M, Xu J, Thibodeau SN, Friedman SL, Martignetti J. A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. CANCER RESEARCH. 2005 Feb;65(4):1213-22.
    PubMed ID: 15735005
  • Klein C, Wu Y, Kruckeberg K, Hebbring S, Anderson S, Cunningham J, Dyck P, Klein D, Thibodeau SN, Dyck PJ. SPTLC1 and RAB7 mutation analysis in dominantly inherited and idiopathic sensory neuropathies. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2005 Jul;76(7):1022-4.
    PubMed ID: 15965219
  • Roberts R, Bergstralh EJ, Farmer S, Jacobson D, McGree M, Hebbring S, Cunningham J, Anderson S, Thibodeau SN, Lieber MM, Jacobsen SJ. Polymorphisms in the 5alpha reductase type 2 gene and urologic measures of BPH. PROSTATE. 2005 Mar;62(4):380-7.
    PubMed ID: 15389785
  • Roberts R, Bergstralh EJ, Cunningham J, Hebbring S, Thibodeau SN, Jacobsen SJ. Androgen receptor gene polymorphisms and increased risk of urologic measures of benign prostatic hyperplasia. AMERICAN JOURNAL OF EPIDEMIOLOGY. 2004 Feb;159(3):269-76.
    PubMed ID: 14742287
  • Schaid DJ, Guenther J, Christensen G, Hebbring S, Rosenow C, Hilker C, McDonnell S, Cunningham J, Slager S, Blute M, Thibodeau SN. Comparison of microsatellites versus single-nucleotide polymorphisms in a genome linkage screen for prostate cancer-susceptibility Loci. AMERICAN JOURNAL OF HUMAN GENETICS. 2004 Dec;75(6):948-65.
    PubMed ID: 15514889
  • Debes J, Yokomizo A, McDonnell S, Hebbring S, Christensen G, Cunningham J, Jacobsen SJ, Tindall D, Liu W, Schaid DJ, Thibodeau SN. Gluthatione-S-transferase P1 polymorphism I105V in familial and sporadic prostate cancer. CANCER GENETICS AND CYTOGENETICS. 2004 Nov;155(1):82-6.
    PubMed ID: 15527908
  • French A, Petroni G, Thibideau S, Smolkin M, Bissonette E, Roviello F, Harper J, Koch B, Anderson S, Hebbring S, Powell S. Allelic imbalance of 8p indicates poor survival in gastric cancer. JOURNAL OF MOLECULAR DIAGNOSTICS. 2004 Aug;6(3):243-52.
    PubMed ID: 15269302
  • Slager S, Schaid DJ, Cunningham J, McDonnell S, Marks A, Peterson B, Hebbring S, Anderson S, French A, Thibodeau SN. Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q. AMERICAN JOURNAL OF HUMAN GENETICS. 2003 Mar;72(3):759-62.
    PubMed ID: 12563560
  • Wang L, McDonnell S, Cunningham J, Hebbring S, Jacobsen SJ, Cerhan J, Slager S, Blute M, Schaid DJ, Thibodeau SN. No association of germline alteration of MSR1 with prostate cancer risk. NATURE GENETICS. 2003 Oct;35(2):128-9.
    PubMed ID: 12958598
  • Klein C, Cunningham J, Atkinson E, Schaid DJ, Hebbring S, Anderson S, Klein D, Dyck PJ, Litchy WJ, Thibodeau SN, Dyck P. The gene for HMSN2C maps to 12q23-24: a region of neuromuscular disorders. NEUROLOGY. 2003 Apr;60(7):1151-6.
    PubMed ID: 12682323
  • Cunningham J, McDonnell S, Marks A, Hebbring S, Anderson S, Peterson B, Slager S, French A, Blute M, Schaid DJ, Thibodeau SN, Mayo Clinic Rochester Minnesota. Genome linkage screen for prostate cancer susceptibility loci: results from the Mayo Clinic Familial Prostate Cancer Study. PROSTATE. 2003 Dec;57(4):335-46.
    PubMed ID: 14601030