Marshfield Clinic physicians have been routinely using computers as a part of every patient encounter for over a decade. Marshfield Clinic develops much of its own clinical software, allowing new ideas to be implemented quickly. CattailsMD, an in-house developed electronic health record (EHR) system, was the first physician practice-driven EHR accredited by CCHIT.

Office of Research Computing and Analytics (ORCA) provides and supports a scalable, scientific computational infrastructure to researchers throughout MCRI and MCHS as well as technical consulting for various projects. The Research Computational Facility (Laird Datacenter) currently consists of 4 IBM Blade centers, 25 IBM Blade servers, 13 VMWARE hosts, 150 virtual servers, 3 Storage Area Network (SAN) appliances, 1 Network Attached Storage (NAS) appliance, 18 node High Performance Computing (HPC) cluster, and Cisco security/network appliances. The three SAN appliances manage 60+ TB of high performance disk. The facility also contains a scalable Isilon NAS appliance hosting 350 TB of storage for Big Data storage needs. The Laird Datacenter also hosts a collaborative HPC cluster consisting of a DDN storage appliance with 130 TB of GPFS storage and 18 server nodes with 160 cores of computer power and 1792 GB of RAM. 

ORCA staff members are subdivided into two major groups that provide support to MCRI and MCHS researchers over the entire lifecycle of a project. Data analysts are specialized in data abstraction and analysis to assess study feasibility, generate preliminary data for projects, and develop RedCap research databases for data entry by research coordinators and other MCRI staff. Biostatisticians perform power analysis to determine the appropriate sample size for research projects, assist in project development with respect to experimental design, data collection methods, and statistical analysis, perform statistical analyses on research data, and assist in interpretation of experimental results for publication.

The Research Analytics and Data Management (RADM) core in ORCA supports researcher access to the Marshfield Clinical Research Data Warehouse (RDW). The RDW contains 9.1 million patient-years of clinical data with digital records extending back to 1960. The RDW receives daily feeds from the Clinical Data Warehouse (CDW), which is fed by all major Marshfield Clinic systems as well as numerous affiliated healthcare providers.