• Scott Hebbring PhD

  • Research Scientist-Genetics


    • Center for Precision Medicine Research
    • 1000 North Oak Ave. MLR Marshfield, WI 54449

Education


2012 to 2014:
Computation and Informatics in Biology and Medicine (CIBM) training program Research conducted under Dr. Murray Brilliant and Dr. David Page., University of Wisconsin Madison, Madison
2007 to 2012:
PhD, Ph.D. in Biochemistry and Molecular Biology. Research conducted under Dr. Richard Weinshilboum., Mayo Clinic Graduate School, Rochester
2007 to 2007:
Human Genome Analysis: Genetic Analysis of Multifactorial Disease, Wellcome Trust Institute
1996 to 2000:
BS, Bachelor of Science in Biochemistry and Molecular Biology, University of Wisconsin Eau Claire, Eau Claire

Work Experience


2017 to Present:
Research Scientist, Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield
2013 to 2017:
Associate Research Scientist, Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield
2012 to 2012:
Postdoctoral Fellow, Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield
2001 to 2007:
Senior Research Technologist, Experimental Pathology Laboratory, Mayo Clinic, Rochester
1999 to 2000:
Student Research Internship under Dr. Jon Scales, University of Wisconsin Eau Claire, Eau Claire
1998 to 1999:
Student Reseach Internship under Dr. Victoria Vander Noot, Sandia National Laboratory, Livermore

Honors & Awards


Patent: SULT1A1 duplication/deletion (Patent number 7674583)

Statement


Dr. Hebbring is a Research Scientist in the Center for Precision Medicine Research at Marshfield Clinic. He completed his doctoral training at Mayo Clinic with a focus on pharmacogenomics. Dr. Hebbring continued his training as a post-doctoral fellow in UW-Madison’s Computational and Informatics in Biology and Medicine (CIBM) training program. His current research is multidisciplinary that combines statistical genetics and medical informatics with molecular biology. The lab utilizes Marshfield Clinic’s extensive electronic health recorded and 20,000 Marshfield Clinic patients that make up a highly informative biobank. With these resources, the lab focuses on the genetic causes of human disease in both families and populations of unrelated individuals. The goal is to return genetic results to the patient and healthcare system to prevent, treat, and better understanding the biological etiologies of human disease.

Research Interests


Human Genetics

Select Publications


  • Hebbring S. Genomic and Phenomic Research in the 21st Century. Trends Genet.. 2019 January; 35(1):29-41.
    PubMed ID: 30342790
  • Safarova MS, Satterfield BA, Fan X, Austin EE, Ye Z, Bastarache L,...Hebbring SJ. A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR. NPJ Genom Med. 2019 February 11; 4 :3.
    PubMed ID: 30774981
  • Zhang X, Veturi Y, Verma S, Bone W, Verma A, Lucas A,...Ritchie MD [including Hebbring S.] Detecting potential pleiotropy across cardiovascular and neurological diseases using univariate, bivariate, and multivariate methods on 43,870 individuals from the eMERGE network. Pac Symp Biocomput. 2019 January; 24 :272-283.
    PubMed ID: 30864329
  • Carter TC, Hebbring SJ, Liu J, Mosley JD, Shaffer CM, Ivacic LC,...Belongia EA [including Kopitzke S, Stefanski EL, Strenn R, Meece J, Brilliant MH.] Pilot screening study of targeted genetic polymorphisms for association with seasonal influenza hospital admission. J. Med. Virol.. 2018 March; 90(3):436-446.
    PubMed ID: 29053189
  • Huang X, Elston RC, Rosa GJ, Mayer J, Ye Z, Kitchner T,...Hebbring SJ [including Brilliant MH.] Applying Family Analyses to Electronic Health Records to Facilitate Genetic Research. BIOINFORMATICS. 2018 February 15; 34(4):635-642. doi: doi: 10.1093/bioinformatics/btx569.
    PubMed ID: 28968884
  • Blue E, Louie TL, Chong JX, Hebbring SJ, Barnes KC, Rafaels NM,...Emond MJ. Variation in Cilia Protein Genes and Progression of Lung Disease in Cystic Fibrosis. Ann Am Thorac Soc.. 2018 April; 15(4):440-448.
    PubMed ID: 29323929
  • Bastarache L, Hughey JJ, Hebbring S, Marlo J, Zhao W, Ho WT,...Denny JC [including Brilliant M.] Phenotype risk scores identify patients with unrecognized Mendelian disease patterns. SCIENCE. 2018 March 16; 359(6381):1233-1239.
    PubMed ID: 29590070
  • Karnes JH, Bastarache L, Shaffer CM, Gaudieri S, Xu Y, Glazer AM,...Denny JC [including Ye Z, Mayer JG, Brilliant MH, Hebbring SJ.] (2017 May 10). Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants. Sci Transl Med. 9(389)
    PubMed ID: 28490672
  • Liu J, Zhao R, Ye Z, Frey AJ, Schriver ER, Snyder NW, Hebbring SJ. (2017 November 1). Relationship of SULT1A1 copy number variation with estrogen metabolism and human health. J. Steroid Biochem. Mol. Biol.. 174 :169-75.
    PubMed ID: 28867356
  • Fritsche LG, Igl W, Bailey JN, Grassmann F, Sengupta S, Bragg-Gresham JL,...Heid IM [including Hebbring SJ, Kitchner TE, Brilliant MH.] (2016 February 21). A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet. 48(2):134-43..
    PubMed ID: 26691988
  • Simonti CN, Vernot B, Bastarache L, Bottinger E, Carrell DS, Chisholm RL,...Capra JA [including Hebbring SJ.] (2016 February 12). The phenotypic legacy of admixture between modern humans and Neandertals. SCIENCE. 351(6274):737-41.
    PubMed ID: 26912863
  • Mosley JD, Witte JS, Larkin EK, Bastarache L, Shaffer CM, Karnes JH,...Denny JC [including Hebbring SJ, Brilliant MH, Mayer J, Ye Z.] (2016 April 25). Identifying genetically driven clinical phenotypes using linear mixed models. Nat Commun. 7 :11433.
    PubMed ID: 27109359
  • Maadooliat M, Bansal NK, Upadhya J, Farazi MR, Li X, He MM,...Schrodi SJ [including Hebbring SJ, Ye Z.] (2016 December 12). The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem. Front Genet. 7 :217.
    PubMed ID: 28018425
  • Verma A, Verma SS, Pendergrass SA, Crawford DC, Crosslin DR, Kuivaniemi H,...Tromp G [including Peissig P, Hebbring S.] (2016). eMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants. BMC Med Genomics. 9 Suppl 1 :32.
    PubMed ID: 27535653
  • Kim T, Havighurst T, Kim K, Hebbring SJ, Ye Z, Aylward J,...Spiegelman VS. (2016 November 14). RNA-Binding Protein IGF2BP1 in Cutaneous Squamous Cell Carcinoma. J Invest Dermatol.
    PubMed ID: 27856289
  • Liu J, Ye Z, Mayer JG, Hoch BA, Green C, Rolak L,...Hebbring SJ [including Cold C, Brilliant MH.] (2016 October). Phenome-wide association study maps new diseases to the human major histocompatibility complex region. J Med Genet. 53(10):681-9.
    PubMed ID: 27287392
  • Ye Z, Mayer JG, Ivacic LC, Zhou Z, He M, Schrodi SJ,...Hebbring S [including Brilliant MH.] (2015 April). Phenome-wide association studies (PheWASs) for functional variants. Eur J Hum Genet. 23(4):523-9.
    PubMed ID: 25074467
  • He M, Person TN, Hebbring S, Heinzen E, Ye Z, Schrodi SJ,...Wang K [including McPherson EW, Peissig PL, Brilliant MH.] (2015 April). SeqHBase: a big data toolset for family based sequencing data analysis. JOURNAL OF MEDICAL GENETICS. 52(4):282-8.
    PubMed ID: 25587064
  • Zhang W, Yu Y, Hertwig F, Thierry-Mieg J, Zhang W, Thierry-Mieg D,...Fischer M [including Brilliant MH, He MM, Hebbring S.] (2015). Comparison of RNA-seq and microarray-based models for clinical endpoint prediction. Genome Biol.. 16 :133.
    PubMed ID: 26109056
  • Van Driest SL, McGregor TL, Velez Edwards DR, Saville BR, Kitchner TE, Hebbring SJ,...Denny JC [including Brilliant M.] (2015). Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy. PLoS One. 10(6):e0127791.
    PubMed ID: 26030142
  • Rastegar-Mojarad M, Ye Z, Kolesar JM, Hebbring SJ, Lin SM. (2015 April). Opportunities for drug repositioning from phenome-wide association studies. Nat. Biotechnol.. 33(4):342-5.
    PubMed ID: 25850054
  • Hebbring SJ, Rastegar-Mojarad M, Ye Z, Mayer J, Jacobson C, Lin S. (2015 June 15). Application of clinical text data for phenome-wide association studies (PheWASs). BIOINFORMATICS. 31(12):1981-7.
    PubMed ID: 25657332
  • Hebbring S. (2014 February). The Challenges, Advantages, and Future of Phenome-Wide Association Studies. IMMUNOLOGY. 141(2):157-65.
    PubMed ID: 24147732
  • Cronin RM, Field JR, Bradford Y, Shaffer CM, Carroll RJ, Mosley JD,...Denny JC [including Hebbring SJ, Peissig PL, Brilliant MH.] (2014 August 5). Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index. Front Genet. 5 :250.
    PubMed ID: 25177340
  • Mayer J, Kitchner T, Ye Z, Zhou Z, He M, Schrodi SJ, Hebbring SJ. (2014 December). Use of an electronic medical record to create the marshfield clinic twin/multiple birth cohort. Genet Epidemiol. 38(8):692-8.
    PubMed ID: 25250975
  • Barrie ES, Weinshenker D, Verma A, Pendergrass SA, Lange LA, Ritchie MD,...Sadee W [including Brilliant MH, Hebbring SJ.] (2014 December 5). Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity. Circ Res. 115(12):1017-25.
    PubMed ID: 25326128
  • Hebbring S, Slager S, Epperla N, Mazza JJ, Ye Z, Zhou Z,...Schrodi SJ [including Vasco DA, Brilliant MH.] (2013 January). Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia. BLOOD. 121(1):237-8.
    PubMed ID: 23287625
  • Hebbring S, Schrodi SJ, Ye Z, Zhou Z, Page D, Brilliant MH. (2013 April). A PheWAS approach in studying HLA-DRB1*1501 GENES AND IMMUNITY. 14(3):187-91.
    PubMed ID: 23392276
  • Ji Y, Biernacka JM, Hebbring S, Chai Y, Jenkins GD, Batzler A,...Mrazek DA. (2013 October). Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics. Pharmacogenomics J.. 13(5):456-63.
    PubMed ID: 22907730
  • Haas DM, Dantzer J, Lehmann AS, Philips S, Skaar TC, McCormick CL,...Li L [including Hebbring SJ.] (2013 March). The impact of glucocorticoid polymorphisms on markers of neonatal respiratory disease after antenatal betamethasone administration. Am J Obstet Gynecol. 208(3):215.e1-6.
    PubMed ID: 23295978
  • Ellsworth KA, Moon I, Eckloff BW, Fridley BL, Jenkins GD, Batzler A,...Wang L [including Hebbring S.] (2013 March). FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder. Pharmacogenet Genomics. 23(3):156-66.
    PubMed ID: 23324805
  • Hebbring S, Chai Y, Ji Y, Abo R, Jenkins G, Fridley B,...Weinshilboum RM. (2012 March). Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization. JOURNAL OF NEUROCHEMISTRY. 120(6):881-90.
    PubMed ID: 22220685
  • Abo R, Hebbring S, Ji Y, Zhu H, Zeng Z, Batzler A,...Weinshilboum RM. (2012 April). Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics. Pharmacogenetics and Genomics. 22(4):247-253.
    PubMed ID: 22322242
  • Lu L, Cancel-Tassin G, Valeri A, Cussenot O, Lange E, Cooney K,...International Consortium for Prostate Cancer Genetics. (2012 March). Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG PROSTATE. 72(4):410-26.
    PubMed ID: 21748754
  • Bailey-Wilson J, Childs E, Cropp C, Schaid DJ, Xu J, Camp N,...International Consortium for Prostate Cancer Genetics [including Hebbring S.] (2012 June). Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families. BMC Medical Genetics. 13(46)
    PubMed ID: 22712434
  • Ji Y, Nordgren KK, Chai Y, Hebbring SJ, Jenkins GD, Abo RP,...Weinshilboum RM. (2012 October). Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation. Drug Metab. Dispos.. 40(10):1984-92.
    PubMed ID: 22807109
  • Ji Y, Hebbring S, Zhu H, Jenkins G, Biernacka J, Snyder K,...Weinshilboum RM. (2011 January). Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics. CLINICAL PHARMACOLOGY & THERAPEUTICS. 89(1):97-104.
    PubMed ID: 21107318
  • Feng Q, Kalari K, Fridley B, Jenkins G, Ji Y, Abo R,...Weinshilboum RM. (2011 February). Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation. MOLECULAR GENETICS AND METABOLISM. 102(2):126-33.
    PubMed ID: 21093336
  • Christensen G, Baffoe-Bonnie A, George A, Powell I, Bailey-Wilson J, Carpten J,...International Consortium for Prostate Cancer Genetics. (2010 May). Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for Prostate Cancer Genetics using novel sumLINK and sumLOD analyses. PROSTATE. 70(7):735-44.
    PubMed ID: 20333727
  • Fridley B, Jenkins G, Deyo-Svendsen M, Hebbring S, Freimuth R. (2010 June). Utilizing genotype imputation for the augmentation of sequence data. PLoS One. 5(6):e11018.
    PubMed ID: 20543988
  • Wang L, McDonnell S, Hebbring S, Cunningham J, St Sauver J, Cerhan J,...Thibodeau SN. (2008 December). Polymorphisms in mitochondrial genes and prostate cancer risk. Cancer Epidemiol Biomarkers Prev. 17(12):3558-66.
    PubMed ID: 19064571
  • Hebbring S, Moyer A, Weinshilboum RM. (2008). Sulfotransferase gene copy number variation: pharmacogenetics and function. CYTOGENETIC AND GENOME RESEARCH. 123(1-4):205-10.
    PubMed ID: 19287157
  • Johanneson B, McDonnell S, Karyadi D, Hebbring S, Wang L, Deutsch K,...Thibodeau SN. (2008 February). Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb. HUMAN GENETICS. 123(1):65-75.
    PubMed ID: 18066601
  • Cunningham J, Hebbring S, McDonnell S, Cicek M, Christensen G, Wang L,...Thibodeau SN. (2007 May). Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer. Cancer Epidemiol Biomarkers Prev. 16(5):969-78.
    PubMed ID: 17507624
  • Wang L, McDonnell S, Slusser JP, Hebbring S, Cunningham J, Jacobsen SJ,...Thibodeau SN. (2007 April). Two common chromosome 8q24 variants are associated with increased risk for prostate cancer. CANCER RESEARCH. 67(7):2944-50.
    PubMed ID: 17409399
  • Moyer A, Salavaggione O, Hebbring S, Moon I, Hildebrandt M, Eckloff B,...Weinshilboum RM. (2007 December). Glutathione S-transferase T1 and M1: gene sequence variation and functional genomics. CLINICAL CANCER RESEARCH. 13(23):7207-16.
    PubMed ID: 18056202
  • Hebbring S, Adjei A, Baer J, Jenkins G, Zhang J, Cunningham J,...Thibodeau SN. (2007 March). Human SULT1A1 gene: copy number differences and functional implications. HUMAN MOLECULAR GENETICS. 16(5):463-70.
    PubMed ID: 17189289
  • Camp N, Cannon-Albright L, Farnham J, Baffoe-Bonnie A, George A, Powell I,...International Consortium for Prostate Cancer Genetics. (2007 June). Compelling evidence for a prostate cancer gene at 22q12.3 by the International Consortium for Prostate Cancer Genetics. HUMAN MOLECULAR GENETICS. 16(11):1271-8.
    PubMed ID: 17478474
  • Hebbring S, Fredriksson H, White K, Maier C, Ewing C, McDonnell S,...Thibodeau SN. (2006 May). Role of the Nijmegen breakage syndrome 1 gene in familial and sporadic prostate cancer. Cancer Epidemiol Biomarkers Prev. 15(5):935-8.
    PubMed ID: 16702373
  • Schaid DJ, McDonnell S, Zarfas K, Cunningham J, Hebbring S, Thibodeau SN,...Roehl K. (2006 November). Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics. HUMAN GENETICS. 120(4):471-85.
    PubMed ID: 16932970
  • Roberts R, Bergstralh EJ, Farmer S, Jacobson D, Hebbring S, Cunningham J,...Jacobsen SJ. (2006 March). Polymorphisms in genes involved in sex hormone metabolism may increase risk of benign prostatic hyperplasia. PROSTATE. 66(4):392-404.
    PubMed ID: 16302261
  • Mullan R, Bergstralh EJ, Farmer S, Jacobson D, Hebbring S, Cunningham J,...Roberts R. (2006 February). Growth factor, cytokine, and vitamin D receptor polymorphisms and risk of benign prostatic hyperplasia in a community-based cohort of men. UROLOGY. 67(2):300-5.
    PubMed ID: 16461080
  • Xu J, Dimitrov L, Chang B, Adams T, Turner A, Meyers DA,...ACTANE Consortium. (2005 August). A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics. AMERICAN JOURNAL OF HUMAN GENETICS. 77(2):219-29.
    PubMed ID: 15988677
  • Schaid DJ, McDonnell S, Hebbring S, Cunningham J, Thibodeau SN. (2005 May). Nonparametric tests of association of multiple genes with human disease. AMERICAN JOURNAL OF HUMAN GENETICS. 76(5):780-93.
    PubMed ID: 15786018
  • Narla G, Difeo A, Reeves H, Schaid DJ, Hirshfeld J, Hod E,...Martignetti J. (2005 February). A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. CANCER RESEARCH. 65(4):1213-22.
    PubMed ID: 15735005
  • Klein C, Wu Y, Kruckeberg K, Hebbring S, Anderson S, Cunningham J,...Dyck PJ. (2005 July). SPTLC1 and RAB7 mutation analysis in dominantly inherited and idiopathic sensory neuropathies. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 76(7):1022-4.
    PubMed ID: 15965219
  • Roberts R, Bergstralh EJ, Farmer S, Jacobson D, McGree M, Hebbring S,...Jacobsen SJ. (2005 March). Polymorphisms in the 5alpha reductase type 2 gene and urologic measures of BPH. PROSTATE. 62(4):380-7.
    PubMed ID: 15389785
  • Roberts R, Bergstralh EJ, Cunningham J, Hebbring S, Thibodeau SN, Jacobsen SJ. (2004 February). Androgen receptor gene polymorphisms and increased risk of urologic measures of benign prostatic hyperplasia. AMERICAN JOURNAL OF EPIDEMIOLOGY. 159(3):269-76.
    PubMed ID: 14742287
  • Schaid DJ, Guenther J, Christensen G, Hebbring S, Rosenow C, Hilker C,...Thibodeau SN. (2004 December). Comparison of microsatellites versus single-nucleotide polymorphisms in a genome linkage screen for prostate cancer-susceptibility Loci. AMERICAN JOURNAL OF HUMAN GENETICS. 75(6):948-65.
    PubMed ID: 15514889
  • Debes J, Yokomizo A, McDonnell S, Hebbring S, Christensen G, Cunningham J,...Thibodeau SN. (2004 November). Gluthatione-S-transferase P1 polymorphism I105V in familial and sporadic prostate cancer. CANCER GENETICS AND CYTOGENETICS. 155(1):82-6.
    PubMed ID: 15527908
  • French A, Petroni G, Thibideau S, Smolkin M, Bissonette E, Roviello F,...Powell S. (2004 August). Allelic imbalance of 8p indicates poor survival in gastric cancer. JOURNAL OF MOLECULAR DIAGNOSTICS. 6(3):243-52.
    PubMed ID: 15269302
  • Slager S, Schaid DJ, Cunningham J, McDonnell S, Marks A, Peterson B,...Thibodeau SN. (2003 March). Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q. AMERICAN JOURNAL OF HUMAN GENETICS. 72(3):759-62.
    PubMed ID: 12563560
  • Wang L, McDonnell S, Cunningham J, Hebbring S, Jacobsen SJ, Cerhan J,...Thibodeau SN. (2003 October). No association of germline alteration of MSR1 with prostate cancer risk. NATURE GENETICS. 35(2):128-9.
    PubMed ID: 12958598
  • Klein C, Cunningham J, Atkinson E, Schaid DJ, Hebbring S, Anderson S,...Dyck P. (2003 April). The gene for HMSN2C maps to 12q23-24: a region of neuromuscular disorders. NEUROLOGY. 60(7):1151-6.
    PubMed ID: 12682323
  • Cunningham J, McDonnell S, Marks A, Hebbring S, Anderson S, Peterson B,...Mayo Clinic Rochester Minnesota. (2003 December). Genome linkage screen for prostate cancer susceptibility loci: results from the Mayo Clinic Familial Prostate Cancer Study. PROSTATE. 57(4):335-46.
    PubMed ID: 14601030