Alexandra Linz , PhD

Select Publications

• Thompson LR, Sanders JG, McDonald D, Amir A, Ladau J, Locey KJ,...Linz AM. A communal catalogue reveals Earth's multiscale microbial diversity. Nature. 2017 November 23; 551(7681):457-463. PMCID: PMC6192678.
  PubMed ID: 29088705

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• Linz AM, Crary BC, Shade A, Owens S, Gilbert JA, Knight R, McMahon KD. Bacterial Community Composition and Dynamics Spanning Five Years in Freshwater Bog Lakes. mSphere. 2017 June 28; 2(3) PMCID: PMC5489657.
  PubMed ID: 28680968

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• Linz AM, He S, Stevens SLR, Anantharaman K, Rohwer RR, Malmstrom RR,...McMahon KD. Freshwater carbon and nutrient cycles revealed through reconstructed population genomes. PeerJ. 2018 December 10; 6 :e6075. PMCID: PMC6292386.
  PubMed ID: 30581671

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• Linz AM. From Microbes to Ecosystems: Time Series Provide Insight Into How Microbial Metabolisms Scale to Ecosystem Functions. 2018 January 1;

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• García-García N, Tamames J, Linz AM, Pedrós-Alió C, Puente-Sánchez F. Microdiversity ensures the maintenance of functional microbial communities under changing environmental conditions. ISME J. 2019 December; 13(12):2969-2983. PMCID: PMC6864100.
  PubMed ID: 31417155

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• He S, Lau MP, Linz AM, Roden EE, McMahon KD. Extracellular Electron Transfer May Be an Overlooked Contribution to Pelagic Respiration in Humic-Rich Freshwater Lakes. mSphere. 2019 January 23; 4(1) PMCID: PMC6344600.
  PubMed ID: 30674644

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• Linz AM, K McMahon, S Jones, A Shade, R Newton, E Read,...S Schmitz. Microbial Observatory at North Temperate Lakes LTER High-resolution temporal and spatial dynamics of microbial community structure in freshwater bog lakes 2005-2009 original format. 2019 January 1;

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• Linz AM, Frank Aylward, Stefan Bertilsson, Katherine McMahon. Time-series metatranscriptomes reveal conserved patterns between phototrophic and heterotrophic microbes in diverse freshwater systems. 2020 January 1;

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• Myers KS, Vera JM, Lemmer KC, Linz AM, Landick R, Noguera DR, Donohue TJ. Genome-Wide Identification of Transcription Start Sites in Two Alphaproteobacteria, Rhodobacter sphaeroides 2.4.1 and Novosphingobium aromaticivorans DSM 12444. Microbiol Resour Announc. 2020 September 3; 9(36) PMCID: PMC7471390.
  PubMed ID: 32883797

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• Fernandez L, Peura S, Eiler A, Linz AM, McMahon KD, Bertilsson S. Diazotroph Genomes and Their Seasonal Dynamics in a Stratified Humic Bog Lake. Front Microbiol. 2020 July 1; 11 :1500. PMCID: PMC7341956.
  PubMed ID: 32714313

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• Kieft K, Breister AM, Huss P, Linz AM, Zanetakos E, Zhou Z,...Anantharaman K. Virus-associated organosulfur metabolism in human and environmental systems. Cell Rep. 2021 August 3; 36(5):109471.
  PubMed ID: 34348151

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• Linz AM, Ma Y, Perez JM, Myers KS, Kontur WS, Noguera DR, Donohue TJ. Aromatic dimer dehydrogenases from Novosphingobium aromaticivorans reduce monoaromatic diketones. [published online ahead of print 2021 October 6]. Appl Environ Microbiol. :AEM0174221.
  PubMed ID: 34613756

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• Linz AM, Ma Y, Scholz S, Noguera DR, Donohue TJ. iNovo479: Metabolic Modeling Provides a Roadmap to Optimize Bioproduct Yield from Deconstructed Lignin Aromatics by Novosphingobium aromaticivorans. Metabolites. 2022 April 18;12(4). doi: 10.3390/metabo12040366. PMCID: PMC9028409.
  PubMed ID: 35448553

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• He S, Linz AM, Stevens SLR, Tran PQ, Moya-Flores F, Oyserman BO,...McMahon KD. Diversity, distribution, and expression of opsin genes in freshwater lakes. Mol Ecol. 2023 June;32(11):2798-2817. doi: 10.1111/mec.16891.
  PubMed ID: 36799010

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• Linz AM, Anderson JL, Meece JK. Detection of Blastomyces gilchristii via metagenomic sequencing in outbreak-associated soils. Med Mycol. 2024 January 9. doi: 10.1093/mmy/myad140.
  PubMed ID: 38171496

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• Linz AM, Frost HM, Kitchner T, Anderson JL, Meece J. Clinical Presentation of Blastomycosis is Associated With Infecting Species, Not Host Genotype. Clin Med Res. 2024 March;22(1):6-12. doi: 10.3121/cmr.2024.1880. PMCID: PMC11149952.
  PubMed ID: 38609141

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• Kugeler KJ, Scotty E, Hinckley AF, Hook SA, Nawrocki CC, Nikolai AM,...Schotthoefer AM [including Linz AM, Meece J.] Epidemiology of Lyme Disease as Identified Through Electronic Health Records in a Large Midwestern Health System, 2016-2019. Open Forum Infect Dis. 2025 February;12(2):ofae758. doi: 10.1093/ofid/ofae758. PMCID: PMC11793028.
  PubMed ID: 39906321

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• Kugeler KJ, Scotty E, Earley A, Hinckley AF, Hook SA, Nawrocki CC,...Schotthoefer AM [including Linz AM, Meece J.] Lyme Disease Testing Practices, Wisconsin, USA, 2016-2019. Emerg Infect Dis. 2025 July;31(7):1421-1424. doi: 10.3201/eid3107.250009. PMCID: PMC12205465.
  PubMed ID: 40562745

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• Rodríguez-Castro L, Myers KS, Linz AM, Mettert EL, Camp W, Kiley PJ,...Donohue TJ. Novosphingobium aromaticivorans LigR coordinates transcription of genes involved in metabolism of multiple types of aromatics. mSystems. 2025 December 17;10(12):e0146925. doi: 10.1128/msystems.01469-25. PMCID: PMC12710314.
  PubMed ID: 41313017

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• Myers KS, Linz AM, Baumgart LA, Zhang Y, Blaby I, Mewalal R,...Donohue TJ. Using DNA affinity purification sequencing (DAP-seq) to identify in vitro binding sites of potential Novosphingobium aromaticivorans DSM12444 transcription factors. Microbiol Resour Announc. 2025 August 14;14(8):e0026025. doi: 10.1128/mra.00260-25. PMCID: PMC12352068.
  PubMed ID: 40693769

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• Hirsch AG, Schwartz BS, Poulsen MN, Schotthoefer AM, Sundaram ME, Lemieux JE,...Hook SA [including Linz AM.] Using Electronic Health Records to Enhance Lyme Disease Surveillance: Protocol for the SubLyme Network. JMIR Res Protoc.. 2026 July 8;15:e94921. doi: 10.2196/94921. PMCID: PMC13392523.
  PubMed ID: 42418240

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• Linz AM, Scotty E, Meece JK, Nawrocki CC, Kugeler KJ, Hook SA,...Schotthoefer AM. Exploring data-driven algorithms to identify Lyme disease cases in electronic health records. PLoS One. 2026 August 12;21(8):e0349121. doi: 10.1371/journal.pone.0349121. PMCID: PMC13466019.
  PubMed ID: 42585140

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