• Shereif Rezkalla MD

  • Emeritus Researcher

    • MCRI - MCRI-Clinical Research Center
    • 1000 North Oak Avenue 1R4 Marshfield, WI 54449


Interventional Cardiology, Wayne State University - Hospitals, Detroit, MI
Cardiology, Wayne State University - Hospitals, Detroit, MI
Internal Medicine, Wayne State University - Hospitals, Detroit, MI
Rotating, St. John Macomb Hospital, Warren
Department of Internal Medicine & Surgery, El Mabarra Hospital, Assuit, Egypt
Flexible, Assuit University Affiliated Hospitals, Assuit, Egypt
MD, MBBCH, Assuit University Medical School, Assuit, Egypt

Work Experience

2024 to Present:
Emeritus Researcher - Fritz Wenzel Center for Clinical Research - MCRI, Marshfield Clinic Health Systems, Marshfield, WI
1994 to Present:
Cardiologist, Sacred Heart Hospital, Tomahawk
1991 to 2024:
Cardiologist, Riverview Hospital, Wisconsin Rapids
1989 to 2024:
Interventional Cardiologist, Marshfield Clinic, Inc., Marshfield, WI
1989 to 2017:
Staff Cardiologist, Ministry St. Joseph's Hospital, Marshfield, WI
2000 to 2015:
Clinical Professor of Medicine, University of Wisconsin, Madison
1993 to 2010:
Director of Cardiovascular Research, Department of Cardiology, Marshfield Clinic, Inc., Marshfield, WI
1995 to 2000:
Clinical Associate Professor of Medicine, University of Wisconsin, Madison
1989 to 1995:
Assistant Clinical Professor of Medicine, University of Wisconsin, Madison, WI
1976 to 1978:
Director, Dewena and El Balayza Health Unit, Assuit, Egypt

Board Certifications

1985 to Present:
American Board of Internal Medicine
1989 to Present:
American Board of Cardiovascular Diseases
1999 to Present:
American Board of Interventional Cardiology

Professional Societies

American College of Cardiology, Member
American College of Physicians, Member
American Federation for Medical Research, Member
Wisconsin Medical Society, Member
American Medical Association, Member
Society of Cardiovascular Computed Tomography, Member

Select Publications

  • Rezkalla SH, Khatib G. (1985). Diffuse eosinophlic gastroenteritis with normal endoscopic examination. Department of Medicine Bulletin. 1 :29-31.
  • Rezkalla SH, Khatib G, Khatib R. (1986 April). Coxsackievirus B3 murine myocarditis: deleterious effects of nonsteroidal anti-inflammatory agents. J Lab Clin Med. 107(4):393-395.
    PubMed ID: 2420912
  • Turi ZG, Rezkalla SH, Campbell CA, Kloner RA.. (1988 September). Amelioration of ischemia during angioplasty of the left anterior descending coronary artery with an autoperfusion catheter. Am J Cardiol. 62(9):513-517.
    PubMed ID: 2970787
  • Rezkalla SH, Kloner RA., Khatib G, Smith F, Khatib R. (1988 August). Effect of metoprolol in acute coxsackievirus B3 murine myocarditis. J Am Coll Cardiol. 12(2):412-414.
    PubMed ID: 2839568
  • Rezkalla SH, Kloner RA., Sowers J, Khatib R. (1988 June). Atrial natriuretic peptide in acute coxsackievirus murine myocarditis. Am J Cardiol. 61(15):1361-1362.
    PubMed ID: 2837075
  • Rezkalla SH, Khatib R, Khatib G, Smith F, Walsh M, Sowers J, Kloner RA.. (1988 July). Effect of indomethacin in the late phase of coxsackievirus myocarditis in a murine model. J Lab Clin Med. 112(1):118-121.
    PubMed ID: 2839587
  • Rezkalla SH, Moushmoush B, Connors BC, Turi ZG. (1988). Monitoring of ischemia during percutaneous coronary angioplasty: influence of guidewire, balloon placement, and lead selection. Cathet Cardiovasc Diagn. 15(4):233-236.
    PubMed ID: 2976305
  • Turi ZG, Rezkalla SH, Campbell CA, Kloner RA.. (1988). Coronary angioplasty in patients with proximal epicardial stenosis. Results of a study of the autoperfusion balloon catheter in humans. Am J Cardiol. 62 :513-517.
  • Rezkalla SH, Kloner RA., Khaw BA, Haber E, Fallon JT, Smith F, Khatib R. (1989 February). Detection of experimental myocarditis by monoclonal antimyosin antibody, Fab fragment. Am Heart J. 117(2):391-395.
    PubMed ID: 2916411
  • Rezkalla SH, Kloner RA.. (1989 March). Management strategies in viral myocarditis. Am Heart J. 117(3):706-708.
    PubMed ID: 2645754
  • Rezkalla SH, Kloner RA., Ensley J, al-Sarraf M, Revels S, Olivenstein A,...Turi ZG. (1989 April). Continuous ambulatory ECG monitoring during fluorouracil therapy: a prospective study. J Clin Oncol. 7(4):509-514.
    PubMed ID: 2466960
  • Campbell CA, Rezkalla SH, Kloner RA., Turi ZG. (1989 October). The autoperfusion balloon angioplasty catheter limits myocardial ischemia and necrosis during prolonged balloon inflation. J Am Coll Cardiol. 14(4):1045-1050.
    PubMed ID: 2794265
  • Campbell CA, Rezkalla SH, Kloner RA., Turi ZG. (1989). Electrocardiographic findings: regional myocardial blood flow and infarct size during 90 minute inflation of autoperfusion catheter. J Am Coll Cardiol. 14 :1045-1050.
  • Hale S, Alker K, Rezkalla SH, Figures G, Kloner RA.. (1989 November). Adverse effects of cocaine on cardiovascular dynamics, myocardial blood flow, and coronary artery diameter in an experimental model. Am Heart J. 118(5 Pt 1):927-933.
    PubMed ID: 2816705
  • Rezkalla SH, Turi ZG, Keedy D, Precevski P, Kloner RA.. (1989). Left main coronary angioplasty in a sheep model using a new left main autoperfusion balloon catheter. J Invasive Cardiology. 1 :199-205.
  • Rezkalla SH, Boden WE, Kloner RA.. (1989). Identification and management of patients at risk for myocardial infarction extension. Practical Cardiology. 15 :50-59.
  • Rezkalla SH, Kloner RA.. (1989 December). Author's reply. Management strategies in viral myocarditis. AMERICAN HEART JOURNAL. 118(6):1355.
  • Rezkalla SH, Hale S, Kloner RA.. (1990 December). Cocaine-induced heart diseases. Am Heart J. 120(6 Pt 1):1403-1408.
    PubMed ID: 2248185
  • Rezkalla SH, Kloner RA., Khatib G, Khatib R. (1990 March). Beneficial effects of captopril in acute coxsackievirus B3 murine myocarditis. CIRCULATION. 81(3):1039-1046.
    PubMed ID: 2155071
  • Khatib R, Reyes MP, Smith F, Khatib G, Rezkalla SH. (1990 July). Enhancement of coxsackievirus B4 virulence by indomethacin. J Lab Clin Med. 116(1):116-120.
    PubMed ID: 1695914
  • Rezkalla SH, Kloner RA., Khatib G, Khatib R. (1990 December). Effect of delayed captopril therapy on left ventricular mass and myonecrosis during acute coxsackievirus murine myocarditis. Am Heart J. 120(6 Pt 1):1377-1381.
    PubMed ID: 2174203
  • Turi ZG, Rezkalla SH, Campbell CA, Kloner RA.. (1990 September). Left main percutaneous transluminal coronary angioplasty with the autoperfusion catheter in an animal model. Cathet Cardiovasc Diagn. 21(1):45-50.
    PubMed ID: 2208267
  • Rezkalla SH, Kloner RA., Khatib G, Khatib R. (1990 November). Author's reply. Beneficial effects of captopril in acute coxsackievirus B3 murine myocarditis. CIRCULATION. 82(5):1882-1883.
  • Hale S, Alker K, Rezkalla SH, Eisenhauer AC, Kloner RA.. (1991 April). Nifedipine protects the heart from the acute deleterious effects of cocaine if administered before but not after cocaine. CIRCULATION. 83(4):1437-1443.
    PubMed ID: 2013159
  • Rezkalla SH, Kloner RA.. (1991). Cardiomyopathy. Cardiovascular Reviews & Reports. 12 :53-66.
  • Rezkalla SH, Kloner RA.. (1991). Myocarditis. Cardiovascular Reviews & Reports. 12 :48-53.
  • Rezkalla SH, Kloner RA.. (1991). Cocaine and vascular thrombosis. Cardiovascular Reviews & Reports. 13 :54-57.
  • Rezkalla SH, Reinhart R. (1991 August). Author's reply. Starting aspirin therapy after operation. CIRCULATION. 84(2):520-526.
  • Rezkalla SH, Reinhart RA. (1992 April). Starting aspirin therapy after operation. CIRCULATION. 85(4):1637.
    PubMed ID: 1555306
  • Kloner RA., Hale S, Alker K, Rezkalla SH. (1992 February). The effects of acute and chronic cocaine use on the heart. CIRCULATION. 85(2):407-419.
    PubMed ID: 1346509
  • Khatib R, Reyes MP, Khatib G, Smith F, Rezkalla SH, Kloner RA.. (1992 February). Focal ventricular thinning caused by indomethacin in the late phase of coxsackievirus B4 murine myocarditis. Am J Med Sci. 303(2):95-98.
    PubMed ID: 1311498
  • Alam S, Rezkalla SH, Farkas P, Turi ZG. (1992 March). Deleterious cardiac effects of captopril during acute myocardial ischaemia in the dog. Cardiovasc Res. 26(3):232-236.
    PubMed ID: 1423417
  • Groden DL, Zhang KQi, Rezkalla SH. (1992). Abnormal calcium tansients and contractile dynamics in rat myocytes exposed to cocaine. J Am Col Cardiology. 19(Suppl A):194A.
  • Wolschleger KG, Rezkalla SH. (1992). Excimer laser coronary angioplasty. Marshfield Clinic Bulletin. 28 :1-5.
  • Rezkalla SH, Hale S, Alker K, Kloner RA.. (1993 March). Flow-function dissociation following an acute dose of cocaine: effect of captopril on coronary flow. Coron Artery Dis. 4(3):271-276.
    PubMed ID: 8269221
  • Rezkalla SH, Mazza JJ, Kloner RA., Tillema VB, Chang S. (1993 July). Effects of cocaine on human platelets in healthy subjects. Am J Cardiol. 72(2):243-246.
    PubMed ID: 8328397
  • Raikar S, Rezkalla SH. (1994 June). Takayasu's arteritis: a report of three cases. Wis Med J. 93(6):261-263.
    PubMed ID: 7915864
  • Rezkalla SH, Raikar S, Kloner RA.. (1996 March). Treatment of viral myocarditis with focus on captopril. Am J Cardiol. 77(8):634-637.
    PubMed ID: 8610616
  • Rezkalla SH. (1997 February). The effect of digoxin on mortality and morbidity in patients with heart failure. The Digitalis Investigation Group. N Engl J Med. 336(8):525-533.
    PubMed ID: 9036306
  • Rezkalla SH. (1997 August). Randomised double-blind trial of fixed low-dose warfarin with aspirin after myocardial infarction. Coumadin Aspirin Reinfarction Study (CARS) Investigators. Lancet. 350(9075):389-396.
    PubMed ID: 9259652
  • Rezkalla SH, Kloner RA.. (1999). Substance abuse and athletes: a cardiovascular nightmare. American Journal of Medicine & Sports. 1 :113-120.
  • Rezkalla SH, Kloner RA.. (2002 February). No-reflow phenomenon. CIRCULATION. 105(5):656-662.
    PubMed ID: 11827935
  • Rezkalla SH, Mesa JE, Sharma PP, Kloner RA.. (2002 July). Myocardial infarction temporally related to ephedra -- a possible role for the coronary microcirculation. WMJ. 101(7):64-66.
    PubMed ID: 12426924
  • Rezkalla SH, Kloner RA.. (2002 November). No-reflow phenomenon. Response. CIRCULATION. 106(20):143e.
    PubMed ID: 12427665
  • Pfeffer MA, McMurray JJV, Velazquez EJ, Rouleau JL, Kober L, Maggioni AP,...Rezkalla SH. (2003 November). Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med. 349(20):1893-1906.
    PubMed ID: 14610160
  • Rezkalla SH, Hayes JJ, Curtis BR, Aster RH. (2003 January). Eptifibatide-induced acute profound thrombocytopenia presenting as refractory hypotension. Catheter Cardiovasc Interv. 58(1):76-79.
    PubMed ID: 12508202
  • Rezkalla SH, Sharma PP, Kloner RA.. (2003 September). Coronary no-flow and ventricular tachycardia associated with habitual marijuana use. Ann Emerg Med. 42(3):365-369.
    PubMed ID: 12944889
  • Rezkalla SH. (2003 October). Successful direct stenting guided by intravascular ultrasound without contrast in a patient with renal dysfunction. J Interv Cardiol. 16(5):449-453.
    PubMed ID: 14603803
  • Rezkalla SH. (2003 October). Contrast nephropathy. Clin Med Res. 1(4):301-304.
    PubMed ID: 15931323
  • Rezkalla SH, Benz MA. (2003). Antiplatelet therapy from clinical trials to clinical practice. Clin Med Res. 1(2):101-104.
    PubMed ID: 15931295
  • Artang R, Jurgensen GW, Frandsen NJ, Abildgaard U, Nielsen JDalsgaard, Rezkalla SH. (2003). Abciximab upregulates the number of glycoprotein IIb/IIIa receptors in vivo. J Am Coll Cardiol. 41 :78A.
  • Kloner RA., Rezkalla SH. (2003 February). Cocaine and the heart. N Engl J Med. 348(6):487-488.
    PubMed ID: 12571254
  • Rezkalla SH, Benz MA. (2004 April). Effectiveness of acetylcysteine on preventing renal dysfunction in patients undergoing coronary procedures. WMJ. 103(1):38-41.
    PubMed ID: 15101466
  • Cannon CP, Braunwald E, McCabe CH, Rader DJ, Rouleau JL, Belder R,...Kieffer EC [including Rezkalla SH.] (2004 April). Intensive versus moderate lipid lowering with statins after acute coronary syndromes. New Engl J Med. 350(15):1495-1504.
    PubMed ID: 15007110
  • Kloner RA., Rezkalla SH. (2004 July). Cardiac protection during acute myocardial infarction: where do we stand in 2004? J Am Coll Cardiol. 44(2):276-286.
    PubMed ID: 15261919
  • Rezkalla SH, Kloner RA.. (2004 December). Ischemic preconditioning and pre-infarction angina in the clinical arena. Nature Clin Practice Cardiovasc Med. 1(2):96-102.
  • Rezkalla SH, Kloner RA.. (2005 June). Preconditioning and the human heart. Panminerva Med. 47(2):69-73.
    PubMed ID: 16210991
  • Ridker PM, Cannon CP, Morrow D, Rifai N, Rose LM, McCabe CH,...Rezkalla SH. (2005 January). C-reactive protein levels and outcomes after statin therapy. N Engl J Med. 352(1):20-28.
    PubMed ID: 15635109
  • Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R,...Maassen KA [including Hayes JJ, Rezkalla SH.] (2005 January). Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 352(3):225-237.
    PubMed ID: 15659722
  • Rezkalla SH, Kloner RA.. (2005 May). Coronary no-reflow phenomenon. Curr Treat Options Cardiovasc Med. 7(1):75-80.
    PubMed ID: 15913506
  • Rezkalla SH, Kloner RA.. (2006 June). Ischemic preconditioning for the clinician Wis Med J. 105(4):22-26.
  • Rezkalla SH, Holmes DR.. (2006 June). Lipid-rich plaque masquerading as a coronary thrombus. Clin Med Res. 4(2):119-122.
    PubMed ID: 16809404
  • Vats HS, Hocking WG, Rezkalla SH. (2006 April). Suspected clopidogrel resistance in a patient with acute stent thrombosis. Nat Clin Pract Cardiovasc Med. 3(4):226-230.
    PubMed ID: 16568132
  • Kloner RA., Rezkalla SH. (2006 May). Preconditioning, postconditioning and their application to clinical cardiology. Cardiovasc Res. 70(2):297-307.
    PubMed ID: 16516180
  • Rezkalla SH, Kloner RA.. (2007 September). Cocaine-induced acute myocardial infarction. Clin Med Res. 5(3):172-176.
    PubMed ID: 18056026
  • Rezkalla SH, Kloner RA.. (2007 December). Preconditioning in humans. Heart Fail Rev. 12(3-4):201-206.
    PubMed ID: 17508280
  • Ghebranious N, Giampietro PF, Wesbrook FP, Rezkalla SH. (2007 June). A novel microdeletion at 16p11.2 harbors candidate genes for aortic valve development, seizure disorder, and mild mental retardation. Am J Med Genet A. 143A(13):1462-1471.
    PubMed ID: 17568417
  • Rezkalla SH, Ahmed M. (2007 July). Management strategies for ST-elevation myocardial infarction in the emergency department. WMJ. 106(4):219-224.
  • Kloner RA., Rezkalla SH. (2007 September). To drink or not to drink? That is the question. CIRCULATION. 116(11):1306-1317.
    PubMed ID: 17846344
  • Rezkalla SH, Kloner RA.. (2008 December). Coronary no-reflow phenomenon: From the experimental laboratory to the cardiac catheterization laboratory. CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. 72(7):950-957.
    PubMed ID: 19021281
  • Rezkalla SH. (2008 February). To drink or not to drink? That is the question. CIRCULATION. 117(6):e159; author reply e160.
    PubMed ID: 17846344
  • Schwartz GG, Olsson AG, Ballantyne CM, Barter PJ, Holme IM, Kallend D,...Rezkalla SH. (2009 December). Rationale and design of the dal-OUTCOMES trial: efficacy and safety of dalcetrapib in patients with recent acute coronary syndrome. AMERICAN HEART JOURNAL. 158(6):896-901.e3.
  • Schwartz BG, Rezkalla SH, Kloner RA.. (2010 December). Cardiovascular effects of cocaine. CIRCULATION. 122(24):2558-69.
    PubMed ID: 21156654
  • Rezkalla SH, Kloner RA.. (2010 August). Influenza-related Viral Myocarditis in the Era of H1N1 WMJ. 109(4):23-7.
  • Rezkalla SH, Dharmashankar KC, Abdalrahman IB, Kloner RA.. (2010 October). No-Reflow Phenomenon Following Percutaneous Coronary Intervention for Acute Myocardial Infarction: Incidence, Outcome, and Effect of Pharmacologic Therapy. J Interv Cardiol. 23(5):429-36.
    PubMed ID: 20819117
  • Luo J, Mitra S, Ludka T, Rezkalla SH, Sharma PP. (2011 November). Swallow Syncope: A Case Report and Review of the Literature. Clin Med Res. 9(3-4):125-9.
    PubMed ID: 21263060
  • Kanth R, Berg RL, Rezkalla SH. (2012 July). Impact of lunar phase on the incidence of cardiac events. World Journal of Cardiovascular Diseases. 2(3):124-128.
  • Schwartz GG, Olsson AG, Abt M, Ballantyne CM, Barter PJ, Brumm J,...Rezkalla SH. (2012 November). Effects of dalcetrapib in patients with a recent acute coronary syndrome. NEW ENGLAND JOURNAL OF MEDICINE. 367(22):2089-99.
    PubMed ID: 23126252
  • Morrow D, Braunwald E, Bonaca M, Ameriso S, Dalby A, Fish M,...Rezkalla SH. (2012 April). Vorapaxar in the secondary prevention of atherothrombotic events. NEW ENGLAND JOURNAL OF MEDICINE. 366(15):1404-13.
    PubMed ID: 22443427
  • Kanth R, Ittaman S, Rezkalla SH. (2013 June). Circadian Patterns of ST Elevation Myocardial Infarction in the New Millennium. Clinical Medicine & Research. 11(2):66-72.
    PubMed ID: 23580786
  • Sabbagh S, Henry Salzman MM, Kloner RA., Simkhovich B, Rezkalla SH. (2013 August). Remote Ischemic Preconditioning for Coronary Artery Bypass Graft Operations ANNALS OF THORACIC SURGERY. 96(2):727-36.
    PubMed ID: 23816418
  • Mali P, Henry Salzman MM, Vidaillet HJ, Rezkalla SH. (2014 March). Amiodarone Therapy for Cardiac Arrhythmias: Is It Associated with the Development of Cancers? World Journal of Cardiovascular Diseases. 4(3):109-118.
  • Rezkalla SH, Kloner R. (2014 April). Recreational marijuana use: is it safe for your patient? J Am Heart Assoc. 3(2):e000904.
    PubMed ID: 24760963
  • VanWormer JJ, Miller AW, Rezkalla SH. (2014 December). Aspirin overutilization for the primary prevention of cardiovascular disease. Clin Epidemiol.. 6 :433-40.
    PubMed ID: 25506245
  • VanWormer JJ, Miller AW, Rezkalla SH. (2014 November). Identifying opportunities to improve aspirin utilization for the primary prevention of cardiovascular disease in a regional health care system. WMJ. 113(5):190-5; quiz 196.
    PubMed ID: 25739162
  • VanWormer JJ, Miller AW, Rezkalla SH. (2014 September). PS2-12: Opportunities to Improve Aspirin Utilization for the Primary Prevention of Cardiovascular Disease in a Regional Healthcare System Clinical Medicine & Research. 12(1-2):Ps2-12.
  • Ittaman S, VanWormer JJ, Rezkalla SH. (2014 December). The Role of Aspirin in the Prevention of Cardiovascular Disease. Clinical Medicine & Research. 12(3-4):147-54.
    PubMed ID: 24573704
  • Thomas G, Kloner R, Rezkalla SH. (2014 January). Adverse cardiovascular, cerebrovascular, and peripheral vascular effects of marijuana inhalation: what cardiologists need to know. AMERICAN JOURNAL OF CARDIOLOGY. 113(1):187-90.
    PubMed ID: 24176069
  • Soodi D, VanWormer JJ, Rezkalla SH. Aspirin in Primary Prevention of Cardiovascular Events. Clin Med Res. 2020 August 18;18(2-3):89-94. doi: 10.3121/cmr.2020.1548. PMCID: PMC7428211.
    PubMed ID: 32580960
  • Soodi D, VanWormer JJ, Rezkalla SH. Author Response to "Aspirin for Primary Prevention of Atherosclerotic Cardiovascular Disease and Colorectal Carcinomas". Clin Med Res. 2021 March 19;19(1):1-2. doi: 10.3121/cmr.2020.1645. PMCID: PMC7987096.
    PubMed ID: 33547168
  • Rezkalla SH, Kloner RA. Invasive versus Conservative Management in Coronary Artery Disease. Clin Med Res. 2023 June;21(2):95-104. doi: 10.3121/cmr.2023.1806. PMCID: PMC10321727.
    PubMed ID: 37407216
  • Rezkalla SH, Kloner RA. An Urgent Call for Studies That Address the Cardiovascular Consequences of Legalization of Marijuana. Cardiol Res. 2024 April;15(2):86-89. doi: 10.14740/cr1641. PMCID: PMC11027777.
    PubMed ID: 38645832