• David Mcclure PhD

  • Project Scientist II


    • MAR CL_MCRI-MCRI-Clin Epidem and Pop Hlth
    • 1000 North Oak Ave. Marsh Melvin Laird > (30711) Mfd Laird Lw Clin Epidem Marshfield, WI 54449

Education

1980 to 1984:
BS, Physics, Arizona State University, Tempe Arizona
1984 to 1986:
MS, Materials Science, Arizona State University, Tempe Arizona
1995 to 1997:
MS, Medical Physics, University of Colorado Health Sciences Center, Denver Colorado
1998 to 2005:
PhD, Analytical Health Sciences (Epidemiology/Biostatistics), University of Colorado Health Sciences Center, Denver Colorado

Work Experience

2000 to 2002:
Biostatistician and Outcomes Analyst, National Jewish Medical and Research Center, Denver Colorado
2002 to 2012:
Senior Biostatistician/Epidemiologist, Kaiser Permanente Colorado, Denver Colorado
2012 to 2014:
Research Scientist, Marshfield Clinic Research Foundation, Marshfield Wisconsin
2014 to 2015:
Project Scientist/Advisor, CVS Health, Northbrook Illinois
2014 to Present:
Adjunct Assistant Professor, Medical College of Wisconsin, Milwaukee Wisconsin
2016 to Present:
Staff Scientist, Marshfield Clinic Research Institute, Marshfield Wisconsin

Honors & Awards

1995 to 1995:
Colorado Graduate Merit Scholarship
1998 to 1998:
Colorado Governor’s Graduate Merit Fellowship
2004 to 2004:
International Society of Pharmacoepidemiology Student Scholarship
2007 to 2007:
Certificate of Nomination for the Charles C. Shepard Science Award, Centers for Disease Control and Prevention
2008 to 2008:
Citation for excellence in manuscript peer review, Pharmacoepidemiology and Drug Safety
2010 to 2010:
Citation for excellence in manuscript peer review, JAMA- Journal of the American Medical Association
2025 to 2025:
Pharmacoepidemiology & Drug Safety Ronald D. Mann Best Paper Award for 2024

Statement

Dr. McClure is a senior epidemiologist specializing in pharmacoepidemiology with emphasis in vaccine safety and effectiveness. He has collaborated with CCEPH staff for many years via the CDC sponsored Vaccine Safety Datalink prior to his most recent CCEPH appointment in 2016. He also has interests in leading or supporting studies of infectious disease, rural health, or new epidemiologic methods.

Research Interests

Vaccine safety and effectiveness, Pharmacoepidemiology, Epidemiologic methods,
Infectious disease epidemiology, Rural health epidemiology

Select Publications

  • Glanz JM, Wagner N, Narwaney K, Shoup J, McClure DL, McCormick E, Daley MF. (2013 September). A mixed methods study of parental vaccine decision making and parent-provider trust. Acad Pediatr. 13(5):481-488.
    PubMed ID: 24011751
  • Sundaram ME, McClure DL, VanWormer JJ, Friedrich TC, Meece JK, Belongia EA. Influenza Vaccination is Not Associated with Detection of Non-Influenza Respiratory Viruses in Seasonal Studies of Influenza Vaccine Effectiveness. CLINICAL INFECTIOUS DISEASES. 2013 September; 57(6):789-793.
    PubMed ID: 23748138
  • Newcomer S, Hambidge SJ, McClure DL, Daley MF, Klein NP, Glanz JM. (2013 August). Factors that may explain observed associations between trivalent influenza vaccination and gastrointestinal illness in young children. VACCINE. 31(37):3894-3898.
    PubMed ID: 23831326
  • Belongia EA, Sundaram ME, McClure DL, Meece JK, Ferdinands J, VanWormer JJ. Waning vaccine protection against influenza A (H3N2) illness in children and older adults during a single season. VACCINE. 2015 January 1; 33(1):246-51.
    PubMed ID: 24962752
  • Jackson ML, Jackson LA, Kieke B, McClure D, Gaglani M, Murthy K,...Thompson MG. (2015 September 22). Incidence of medically attended influenza infection and cases averted by vaccination, 2011/2012 and 2012/2013 influenza seasons. VACCINE. 33(39):5181-5187.
    PubMed ID: 26271827
  • Glanz JM, Newcomer SR, Daley MF, McClure DL, Baxter RP, Jackson ML,...DeStefano F. (2015 November 27). Cumulative and episodic vaccine aluminum exposure in a population-based cohort of young children. VACCINE. 33(48):6736-44..
    PubMed ID: 26518400
  • Simpson MD, Kieke BA, Sundaram ME, McClure DL, Meece JK, Sifakis F,...Belongia EA. Incidence of Medically Attended Respiratory Syncytial Virus and Influenza Illnesses in Children 6-59 Months Old During Four Seasons. Open Forum Infect Dis.. 2016 April 21; 3(2):ofw081.
    PubMed ID: 27419158
  • Vickers ER, McClure DL, Naleway AL, Jacobsen SJ, Klein NP, Glanz JM,...Belongia EA. (2017 October 13). Risk of venous thromboembolism following influenza vaccination in adults aged 50years and older in the Vaccine Safety Datalink. VACCINE. 35(43):5872-5877.
    PubMed ID: 28888342
  • McCarthy NL, Sukumaran L, Newcomer S, Glanz J, Daley MF, McClure D,...Weintraub E. (2017 December 4). Patterns of childhood immunization and all-cause mortality. VACCINE. 35(48 Pt B):6643-6648.
    PubMed ID: 29061349
  • Sukumaran L, McCarthy NL, Kharbanda EO, Vazquez-Benitez G, Lipkind HS, Jackson L,...Weintraub ES [including McClure DL.] Infant Hospitalizations and Mortality After Maternal Vaccination. PEDIATRICS. 2018 March; 141(3):e20173310.
    PubMed ID: 29463582
  • Glanz JM, Newcomer SR, Daley MF, DeStefano F, Groom HC, Jackson ML,...Zerbo O [including McClure DL.] Association Between Estimated Cumulative Vaccine Antigen Exposure Through the First 23 Months of Life and Non-Vaccine-Targeted Infections From 24 Through 47 Months of Age. JAMA. 2018 March 6; 319(9):906-913.
    PubMed ID: 29509866
  • McClure DL, Jacobsen SJ, Klein NP, Naleway AL, Kharbanda EO, Glanz JM,...McLean HQ. Similar relative risks of seizures following measles containing vaccination in children born preterm compared to full-term without previous seizures or seizure-related disorders. VACCINE. 2019 January 3; 37(1):76-79.
    PubMed ID: 30478005
  • Donahue JG, Kieke BA, King JP, Mascola MA, Shimabukuro TT, DeStefano F,...Belongia EA [including Hanson KE, McClure DL, Olaiya O.] Inactivated influenza vaccine and spontaneous abortion in the Vaccine Safety Datalink in 2012-13, 2013-14, and 2014-15. VACCINE. 2019 October 16; 37(44):6673-6681.
    PubMed ID: 31540812
  • Donahue JG, Kieke BA, Lewis EM, Weintraub ES, Hanson KE, McClure DL,...Belongia EA [including Vickers ER.] Near Real-Time Surveillance to Assess the Safety of the 9-Valent Human Papillomavirus Vaccine. PEDIATRICS. 2019 December;144(6):e20191808. doi: 10.1542/peds.2019-1808. PMCID: PMC7780202.
    PubMed ID: 31740498
  • Glanz JM, Clarke CL, Xu S, Daley MF, Shoup JA, Schroeder EB,...DeStefano F [including McClure DL.] Association Between Rotavirus Vaccination and Type 1 Diabetes in Children. JAMA Pediatr. 2020 May 1;174(5):455-462. doi: 10.1001/jamapediatrics.2019.6324. PMCID: PMC7063538.
    PubMed ID: 32150236
  • Kieke BA, Belongia EA, McClure DL, Shinde V. Prediction of serious RSV-related outcomes in older adults with outpatient RSV respiratory illness during 12 consecutive seasons. Influenza Other Respir Viruses.. 2020 September; 14(5):479-482.
    PubMed ID: 32390298
  • Lakshmi Panagiotakopoulos, Natalie L. McCarthy, Naomi K. Tepper, Elyse O. Kharbanda, Heather S. Lipkind, Gabriela Vazquez-Benitez,...Eric S. Weintraub [including David L. McClure.] Evaluating the Association of Stillbirths After Maternal Vaccination in the Vaccine Safety Datalink. Obstetrics & Gynecology. 2020 December; 136(6):1086-1094. doi: 10.1097/AOG.0000000000004166.
    PubMed ID: 33156197
  • Naleway AL, Crane B, Irving SA, Bachman D, Vesco KK, Daley MF,...Kharbanda EO [including McClure DL.] Vaccine Safety Datalink infrastructure enhancements for evaluating the safety of maternal vaccination. Ther Adv Drug Saf. 2021 June; 12 :20420986211021233. PMCID: PMC8207278.
    PubMed ID: 34178302
  • McClure DL, Cullinane DC, Maldonado IL. Trends in Mortality at a Level II Rural Trauma Center. WMJ. 2021 October; 120(3):178-182.
    PubMed ID: 34710297
  • Glanz JM, Clarke CL, Daley MF, Shoup JA, Hambidge SJ, Williams JTB,...DeStefano F [including McClure DL.] The Childhood Vaccination Schedule and the Lack of Association With Type 1 Diabetes. PEDIATRICS. 2021 December 1; 148(6)
    PubMed ID: 34851413
  • McLean HQ, McClure DL, King JP, Meece JK, Pattinson D, Neumann G,...Belongia EA. mRNA COVID-19 vaccine effectiveness against SARS-CoV-2 infection in a prospective community cohort, rural Wisconsin, November 2020 to December 2021. Influenza Other Respir Viruses.. 2022 July; 16(4):607-612.
    PubMed ID: 35178857
  • Tartof SY, Malden DE, Liu IA, Sy LS, Lewin BJ, Williams JTB,...Qian L [including McClure D.] Health Care Utilization in the 6 Months Following SARS-CoV-2 Infection. JAMA Netw Open. 2022 August 1; 5(8):e2225657.
    PubMed ID: 35960522
  • Binswanger IA, Shetterly SM, Xu S, Narwaney KJ, McClure DL, Rinehart DJ,...Glanz JM. Opioid Dose Trajectories and Associations With Mortality, Opioid Use Disorder, Continued Opioid Therapy, and Health Plan Disenrollment. JAMA Netw Open. 2022 October 3; 5(10):e2234671.
    PubMed ID: 36197665
  • Daley MF, Reifler LM, Glanz JM, Hambidge SJ, Getahun D, Irving SA,...DeStefano F [including McClure DL.] Association Between Aluminum Exposure From Vaccines Before Age 24 Months and Persistent Asthma at Age 24 to 59 Months. Acad Pediatr. 2023 January; 23(1):37-46.
    PubMed ID: 36180331
  • Katherine Yih W, Daley MF, Duffy J, Fireman B, McClure D, Nelson J,...Maro JC. Tree-based data mining for safety assessment of first COVID-19 booster doses in the Vaccine Safety Datalink. VACCINE. 2023 January 9; 41(2):460-466.
    PubMed ID: 36481108
  • Xu S, Huang R, Sy LS, Hong V, Glenn SC, Ryan DS,...Qian L [including McClure D.] A safety study evaluating non-COVID-19 mortality risk following COVID-19 vaccination. VACCINE. 2023 January 16; 41(3):844-854. doi: 10.1016/j.vaccine.2022.12.036. PMCID: PMC9763207.
    PubMed ID: 36564276
  • Yih WK, Daley MF, Duffy J, Fireman B, McClure D, Nelson J,...Maro JC. A broad assessment of covid-19 vaccine safety using tree-based data-mining in the vaccine safety datalink. VACCINE. 2023 January 16; 41(3):826-835. PMCID: PMC9755007.
    PubMed ID: 36535825
  • Petrie JG, King JP, McClure DL, Rolfes MA, Meece JK, Pattinson D,...McLean HQ [including Belongia EA.] Effectiveness of first and second COVID-19 mRNA vaccine monovalent booster doses during a period of circulation of Omicron variant sublineages: December 2021-July 2022. Influenza Other Respir Viruses.. 2023 March; 17(3):e13104. doi: 10.1111/irv.13104. PMCID: PMC9975792.
    PubMed ID: 36875208
  • Katherine Yih W, Daley MF, Duffy J, Fireman B, McClure DL, Nelson JC,...Maro JC. Safety signal identification for COVID-19 bivalent booster vaccination using tree-based scan statistics in the Vaccine Safety Datalink. VACCINE. 2023 August 14; 41(36):5265-5270. doi: 10.1016/j.vaccine.2023.07.010.
    PubMed ID: 37479610
  • Glanz JM, Xu S, Narwaney KJ, McClure DL, Rinehart DJ, Ford MA,...Binswanger IA. Association Between Opioid Dose Reduction Rates and Overdose Among Patients Prescribed Long-Term Opioid Therapy. Subst Abus. 2023 September; 44(3):209-219.
    PubMed ID: 37702046
  • Xu S, Narwaney KJ, Nguyen AP, Binswanger IA, McClure DL, Glanz JM. An individual segmented trajectory approach for identifying opioid use patterns using longitudinal dispensing data. Pharmacoepidemiol Drug Saf. 2024 January;33(1):e5708. doi: 10.1002/pds.5708. PMCID: PMC10841826 .
    PubMed ID: 37814576
  • Alonge, OD, Marin, M, Hickman, CJ, Sowers, SB, Chen, M, Hao, L,...Nguyen, H. Long-term Neutralizing Antibody Levels Against Measles and Rubella Viruses among Adults with Three Doses of Measles-Mumps-Rubella Vaccine. [published online ahead of print 2024 January 3]. Open Forum Infectious Diseases. 11(1). doi: https://doi.org/10.1093/ofid/ofad700. PMCID: PMC10783245.
    PubMed ID: 38213634
  • Alonge OD, Marin M, Hickman CJ, Sowers SB, Chen MH, Hao L,...Nguyen HQ [including McClure DL.] Long-term Neutralizing Antibody Levels Against Measles and Rubella Viruses Among Adults With 3 Doses of Measles-Mumps-Rubella Vaccine. Open Forum Infect Dis.. 2024 January;11(1):ofad700. doi: 10.1093/ofid/ofad700. PMCID: PMC10783245.
    PubMed ID: 38213634
  • Xu S, Sy LS, Hong V, Farrington P, Glenn SC, Ryan DS,...Qian L [including McClure DL.] Mortality risk after COVID-19 vaccination: A self-controlled case series study. VACCINE. 2024 March 7;42(7):1731-1737. doi: 10.1016/j.vaccine.2024.02.032.
    PubMed ID: 38388239
  • Malden DE, Liu IA, Qian L, Sy LS, Lewin BJ, Asamura DT,...Tartof SY [including McClure DL.] Post-COVID conditions following COVID-19 vaccination: a retrospective matched cohort study of patients with SARS-CoV-2 infection. Nat Commun. 2024 May 22;15(1):4101. doi: 10.1038/s41467-024-48022-9. PMCID: PMC11111703.
    PubMed ID: 38778026
  • Boyce TG, Levine MZ, McClure DL, King JP, Flannery B, Nguyen HQ, Belongia EA. Antibody response to sequential vaccination with cell culture, recombinant, or egg-based influenza vaccines among U.S. adults. Hum Vaccin Immunother. 2024 December 31;20(1):2370087. doi: 10.1080/21645515.2024.2370087. PMCID: PMC11238913.
    PubMed ID: 38982712
  • Boyce TG, McClure DL, Hanson KE, Daley MF, DeSilva MB, Irving SA,...Belongia EA. Lack of Evidence for Vaccine-Associated Enhanced Disease From COVID-19 Vaccines Among Adults in the Vaccine Safety Datalink. Pharmacoepidemiol Drug Saf. 2024 August 1;33(8):e5863. doi: 10.1002/pds.5863. PMCID: PMC11377022.
    PubMed ID: 39155049
  • Nguyen AP, Binswanger IA, Narwaney KJ, Ford MA, McClure DL, Rinehart DJ,...Glanz JM. Association of chronic opioid therapy and opioid use disorder with COVID-19-related hospitalization and mortality: Evidence from three health systems in the United States. Prev Med Rep. 2024 October;46:102832. doi: 10.1016/j.pmedr.2024.102832. PMCID: PMC11374958.
    PubMed ID: 39238780
  • Elkbuli A, Bundschu N, Nasef H, Chin B, McClure DL, Rhodes-Lyons HX. National Analysis of Clinical Outcomes Associated With Cirrhotic Blunt Trauma Patients Undergoing Emergency Laparotomy Versus Non-operative Management: A Propensity Case-Matched Analysis. Am Surg. 2025 March;91(3):336-344. doi: 10.1177/00031348241256078.
    PubMed ID: 38770924
  • Sundaram ME, McClure DL, Alonge O, Stefanski E, Saeedi P, Pirçon J, Nguyen HQ. Seasonal incidence of medically-attended respiratory syncytial virus infection from 2015 to 2019, in a cohort of adults with high-risk conditions. Open Forum Infectious Diseases. 2025 April;12(4):ofaf166. doi: 10.1093/ofid/ofaf166. PMCID: PMC11983387.
    PubMed ID: 40212032
  • Lutz CS, Nguyen HQ, McClure DL, Masters NB, Chen MH, Colley H,...Marin M. Patterns of Decline in Measles, Mumps, and Rubella Neutralizing Antibodies and Protection Levels Through 10 Years After a Second and Third Dose of MMR Vaccine. Open Forum Infect Dis. 2025 April 9;12(4):ofaf188. doi: 10.1093/ofid/ofaf188. PMCID: PMC12013810.
    PubMed ID: 40264986
  • Rhodes-Lyons HX, McClure DL, Hill K, Schultz T, Brandl G, Roberts J,...Pepe A [including Martinek L.] Very Early (= 24 hours) Venous Thromboembolism Prophylaxis Timing Based on Size and Type of Traumatic Brain Injury: A National Retrospective Analysis of Risk Stratification and Anticoagulation History in the Trauma Population. The American Surgeon. 2025 July;91(7):1170-1177. doi: 10.1177/00031348251329469.
    PubMed ID: 40207802
  • Rhodes-Lyons HX, Elkbuli A, Kumar S, Espat NN, Johnson SE, McClure DL, Pepe A. An Exploratory Analysis of Chemical and Mechanical VTE Prophylaxis in Patients with High Rebleeding Risk Traumatic Brain Injury. [published online ahead of print 2025 May 21]. Neurocrit Care. doi: 10.1007/s12028-025-02283-4. PMCID: 4372323.
    PubMed ID: 40399656
  • Sundaram ME, McClure DL, Alonge OD, King JP, Meece JK, Nguyen HQ. Seasonal Incidence of Human Metapneumovirus in High-Risk Adults With Medically Attended Acute Respiratory Illness in a Rural US Community. Influenza Other Respir Viruses. 2025 July 19;19(7):e70119. doi: 10.1111/irv.70119. PMCID: PMC12268109.
    PubMed ID: 40671511
  • McClure DL, Binswanger IA, Narwaney KJ, Ford MA, Nguyen AP, Rinehart DJ, Glanz JM. Patterns of long-term opioid therapy with prior nonpharmacologic pain management utilization. Sci Rep. 2025 August 29;15(1):31924. doi: 10.1038/s41598-025-17979-y. PMCID: PMC12397231.
    PubMed ID: 40883563
  • Donahue JG, Cocoros NM, Kieke BA, Hanson KE, Weintraub ES, Yih WK,...Sundaram ME [including Scotty E, McClure DL, Boyce TG.] Near real-time surveillance and tree-based data mining to assess the safety of respiratory syncytial virus vaccines in older adults in the vaccine safety datalink. VACCINE. 2025 November 20;67:127873. doi: 10.1016/j.vaccine.2025.127873. PMCID: PMC12704511.
    PubMed ID: 41138438
  • Belongia EA, Nguyen HQ, McClure DL, Lewis N, Ellington S, Flannery B, Petrie JG. Approaches to Comparing Influenza Vaccine Effectiveness to Guide Potential Preferential Product Recommendations. [published online ahead of print 2025 October 9]. Clin Infect Dis. doi: 10.1093/cid/ciaf563.
    PubMed ID: 41062090
  • Rhodes-Lyons HX, Elkbuli A, Johnson SE, McClure DL, Pepe A. The subtype matters: unraveling the clinical impact of TBI variants among patients with isolated blunt head injury and skull fractures. Emerg Radiol. 2025 October;32(5):719-729. doi: 10.1007/s10140-025-02365-y. PMCID: 10427240.
    PubMed ID: 40711660
  • Sowers SB, Nguyen HQ, Masters NB, Mercader S, Colley H, McClure DL,...Crooke SN. Durability of the Mumps Antibody Response After the Third Dose of MMR Vaccine. [published online ahead of print 2025 December 8]. J Infect Dis. jiaf520. doi: 10.1093/infdis/jiaf520.
    PubMed ID: 41358808
  • Jorgensen SCJ, McClure DL, Alonge OD, Sundaram ME. Outpatient antibiotic prescribing for medically attended respiratory syncytial virus, influenza, or human metapneumovirus illness among high-risk adults in rural Wisconsin, United States. J Antimicrob Chemother. 2026 January 6;81(1):dkaf412. doi: 10.1093/jac/dkaf412.
    PubMed ID: 41187946
  • Hendrickson JE, Birch RJ, VanWormer JJ, Baumann Kreuziger L, McIntosh JJ, Reese SE,...Sola-Visner MC [including McClure DL.] Neonatal outcomes following maternal red cell transfusions prior to or at delivery. [published online ahead of print 2026 January 12]. J Perinatol. doi: 10.1038/s41372-025-02553-1. PMCID: 6882541.
    PubMed ID: 41526680
  • McClure DL, Hanson KE, Sundaram ME, Kieke BA, Duffy J, McNeil MM,...Weintraub ES. Incident Epilepsy and Vaccination Status or Vaccine Aluminum Exposure in Children Under Age 4. J Pediatr. 2026 May 29;115004. doi: 10.1016/j.jpeds.2026.115004.
    PubMed ID: 41565005
  • Belongia EA, Kieke BA, Hanson KE, McClure DL, Boyce TG, Daley MF,...Sundaram ME. Retrospective cohort study of mRNA COVID-19 vaccine-associated enhanced disease in the Vaccine Safety Datalink, 2021-23. Hum Vaccin Immunother. 2026 December;22(1):2681305. doi: 10.1080/21645515.2026.2681305. PMCID: PMC13248906.
    PubMed ID: 42252746
  • Yih WK, Duffy J, Daley MF, Fireman B, Kim S, Klein N,...Maro JC [including McClure DL.] Using tree-based scan statistics to assess vaccines for possible associations with Guillain-Barré syndrome in the Vaccine Safety Datalink. [published online ahead of print 2026 July 17]. Vaccine. 88:128949. doi: 10.1016/j.vaccine.2026.128949.
    PubMed ID: 42468225
  • Rhodes-Lyons H, Elkbuli A, McClure DL, Martinek L, Pepe A. Elderly at a Crossroads: Rehabilitation and Hospice Outcomes in Small Traumatic Brain Injuries. Clin Med Res. 2026 June 24;24(2):52-59. doi: 10.3121/cmr.2026.2025. PMCID: PMC13343744.
    PubMed ID: 42419813