Clinical Trials

This phase III trial compares the addition of apalutamide, with or without targeted radiation therapy, to standard of care treatment versus standard of care treatment alone in patients with prostate cancer biochemical recurrence (a rise in the blood level of prostate-specific antigen [PSA] after treatment with surgery or radiation). Diagnostic procedures, such as positron emission tomography/computed tomography (PET/CT), may help doctors look for cancer that has spread to the pelvis. Androgens can cause the growth of prostate cancer cells. Apalutamide may help fight prostate cancer by blocking the use of androgens by the tumor cells. Targeted radiation therapy uses high energy rays to kill tumor cells and shrink tumors that have spread. This trial may help doctors determine if using PET/CT results to deliver more tailored treatment (i.e., adding apalutamide, with or without targeted radiation therapy, to standard of care treatment) works better than standard of care treatment alone in patients with biochemical recurrence of prostate cancer.

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming back.

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

This phase II clinical trial evaluates the effectiveness of palbociclib and binimetinib in treating patients with RAS-mutated cancers. Palbociclib and binimetinib are both in a class of medications called kinase inhibitors. They work by blocking the action of abnormal proteins that signals cancer cells to multiply. This trial may help researchers understand if giving the combination of palbociclib and binimetinib can help improve the amount of time before the cancer grows in patients with patients with low grade serous ovarian cancer who have certain changes in the tumor DNA. This trial may also help researchers understand if giving the combination of palbociclib and binimetinib can help improve outcomes among patients with low grade serous ovarian cancer who have previously received a MEK inhibitor. For patients with other tumors, with the exception of lung cancer, colon cancer, melanoma and low grade serous ovarian cancers, this trial may help researchers understand if giving the combination of palbociclib and binimetinib can improve the clinical outcome of survival without progression in patients who have certain changes in their tumor's DNA.

Marshfield Medical Center - Rice Lake

1700 W STOUT ST

RICE LAKE, WI 54868

MC - Chippewa Falls Center

2655 CTY HWY I

CHIPPEWA FALLS, WI 54729

MC - Wausau Center

2727 PLAZA DRIVE

WAUSAU, WI 54401

MMC - Eau Claire Cancer Center

2200 Craig Road

Eau Claire, WI 54701

MMC - Ladysmith

906 College Ave W

Ladysmith, WI 54848

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

MMC - Minocqua

9601 TOWNLINE RD

MINOCQUA, WI 54548

MMC - Neillsville

216 Sunset Place

Neillsville, Wisconsin 54456

MMC - River Region at Stevens Point

MMC - Weston

3501 CRANBERRY BLVD

WESTON, WI 54476

This phase II trial studies how well cabozantinib works in combination with nivolumab and ipilimumab in treating patients with rare genitourinary (GU) tumors that have spread to other places in the body. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving cabozantinib, nivolumab, and ipilimumab may work better in treating patients with genitourinary tumors that have no treatment options compared to giving cabozantinib, nivolumab, or ipilimumab alone.

Diagnostic & Treatment Center

3401 CRANBERRY BLVD

WESTON, WI 54476

Marshfield Clinic At James Beck Cancer Center

2251 NORTH SHORE DR

RHINELANDER, WI 54501

Marshfield Clinic Cancer Care At St Michaels

900 ILLINOIS AVE

STEVENS POINT, WI 54481

Marshfield Medical Center

611 Saint Joseph Ave

Marshfield, WI 54449

Marshfield Medical Center - Rice Lake

1700 W STOUT ST

RICE LAKE, WI 54868

MC - Chippewa Falls Center

2655 CTY HWY I

CHIPPEWA FALLS, WI 54729

MC - Wausau Center

2727 PLAZA DRIVE

WAUSAU, WI 54401

MC - Wisconsin Rapids Center

220 24TH ST SOUTH

WISCONSIN RAPIDS, WI 54494

Mfld Clinic Cancer Care at Sacred Heart Hospital

900 W CLAIREMONT AVE

EAU CLAIRE, WI 54701

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

MMC - Minocqua

9601 TOWNLINE RD

MINOCQUA, WI 54548

MMC - Weston

3501 CRANBERRY BLVD

WESTON, WI 54476

Sacred Heart Hospital (Eau Claire)

900 W Clairemont Ave

Eau Claire, WI 54701

St. Clare's (Weston)

3400 Ministry Parkway

Weston, WI 54476

St. Mary's

2251 North Shore Drive

Rhinelander, WI 54501

St. Michaels Hospital

900 Illinois Ave

Stevens Point, WI 54481

This phase III trial compares the usual chemotherapy treatment to eribulin alone and to eribulin plus gemcitabine in treating patients with urothelial cancer that has spread to other places in the body (metastatic). Chemotherapy drugs, such as eribulin, gemcitabine, docetaxel, and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial aims to see whether adding eribulin to standard of care chemotherapy may work better in treating patients with metastatic urothelial cancer.

Diagnostic & Treatment Center

3401 CRANBERRY BLVD

WESTON, WI 54476

Marshfield Clinic At James Beck Cancer Center

2251 NORTH SHORE DR

RHINELANDER, WI 54501

Marshfield Clinic Cancer Care At St Michaels

900 ILLINOIS AVE

STEVENS POINT, WI 54481

Marshfield Medical Center

611 Saint Joseph Ave

Marshfield, WI 54449

Marshfield Medical Center - Rice Lake

1700 W STOUT ST

RICE LAKE, WI 54868

MC - Chippewa Falls Center

2655 CTY HWY I

CHIPPEWA FALLS, WI 54729

MC - Wausau Center

2727 PLAZA DRIVE

WAUSAU, WI 54401

MC - Wisconsin Rapids Center

220 24TH ST SOUTH

WISCONSIN RAPIDS, WI 54494

Mfld Clinic Cancer Care at Sacred Heart Hospital

900 W CLAIREMONT AVE

EAU CLAIRE, WI 54701

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

MMC - Minocqua

9601 TOWNLINE RD

MINOCQUA, WI 54548

MMC - Weston

3501 CRANBERRY BLVD

WESTON, WI 54476

Sacred Heart Hospital (Eau Claire)

900 W Clairemont Ave

Eau Claire, WI 54701

St. Clare's (Weston)

3400 Ministry Parkway

Weston, WI 54476

St. Mary's

2251 North Shore Drive

Rhinelander, WI 54501

St. Michaels Hospital

900 Illinois Ave

Stevens Point, WI 54481

This partially randomized phase III trial studies how well active surveillance, bleomycin, carboplatin, etoposide, or cisplatin work in treating pediatric and adult patients with germ cell tumors. Active surveillance may help doctors to monitor subjects with low risk germ cell tumors after their tumor is removed. Drugs used in chemotherapy, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

This phase II trial tests whether nivolumab in combination with cabozantinib works in patients with mucosal melanoma. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It works by blocking the action of an abnormal protein that signals tumor cells to multiply. This helps stop the spread of tumor cells. Giving nivolumab in combination with cabozantinib could prevent cancer from returning.

Marshfield Medical Center - Rice Lake

1700 W STOUT ST

RICE LAKE, WI 54868

MC - Chippewa Falls Center

2655 CTY HWY I

CHIPPEWA FALLS, WI 54729

MC - Wausau Center

2727 PLAZA DRIVE

WAUSAU, WI 54401

MC - Wisconsin Rapids Center

220 24TH ST SOUTH

WISCONSIN RAPIDS, WI 54494

MMC - Eau Claire Cancer Center

2200 Craig Road

Eau Claire, WI 54701

MMC - Ladysmith

906 College Ave W

Ladysmith, WI 54848

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

MMC - Minocqua

9601 TOWNLINE RD

MINOCQUA, WI 54548

MMC - Neillsville

216 Sunset Place

Neillsville, Wisconsin 54456

MMC - River Region at Stevens Point

MMC - Weston

3501 CRANBERRY BLVD

WESTON, WI 54476

This phase III trial compares the effect of adding durvalumab to chemotherapy versus chemotherapy alone before surgery in treating patients with upper urinary tract cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as methotrexate, vinblastine, doxorubicin, cisplatin, and gemcitabine work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Durvalumab in combination with chemotherapy before surgery may enhance the shrinking of the tumor compared to chemotherapy alone.

Diagnostic & Treatment Center

3401 CRANBERRY BLVD

WESTON, WI 54476

Marshfield Clinic At James Beck Cancer Center

2251 NORTH SHORE DR

RHINELANDER, WI 54501

Marshfield Clinic Cancer Care At St Michaels

900 ILLINOIS AVE

STEVENS POINT, WI 54481

Marshfield Medical Center

611 Saint Joseph Ave

Marshfield, WI 54449

Marshfield Medical Center - Rice Lake

1700 W STOUT ST

RICE LAKE, WI 54868

MC - Chippewa Falls Center

2655 CTY HWY I

CHIPPEWA FALLS, WI 54729

MC - Wausau Center

2727 PLAZA DRIVE

WAUSAU, WI 54401

MC - Wisconsin Rapids Center

220 24TH ST SOUTH

WISCONSIN RAPIDS, WI 54494

Mfld Clinic Cancer Care at Sacred Heart Hospital

900 W CLAIREMONT AVE

EAU CLAIRE, WI 54701

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

MMC - Minocqua

9601 TOWNLINE RD

MINOCQUA, WI 54548

MMC - Weston

3501 CRANBERRY BLVD

WESTON, WI 54476

Sacred Heart Hospital (Eau Claire)

900 W Clairemont Ave

Eau Claire, WI 54701

St. Clare's (Weston)

3400 Ministry Parkway

Weston, WI 54476

St. Mary's

2251 North Shore Drive

Rhinelander, WI 54501

St. Michaels Hospital

900 Illinois Ave

Stevens Point, WI 54481

This phase II/III trial compares the effect of the combination of high-dose cisplatin every three weeks and radiation therapy versus low-dose cisplatin weekly and radiation therapy for the treatment of patients with locoregionally advanced head and neck cancer. Chemotherapy drugs, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. This study is being done to find out if low-dose cisplatin given weekly together with radiation therapy is the same or better than high-dose cisplatin given every 3 weeks together with radiation therapy in treating patients with head and neck cancer.

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

The general study objective is to obtain sufficient data from a well-controlled prospective clinical study compliant to 21 CRF 812, to provide evidence for the safety and effectiveness of the LIAISON LymeDetect assay using the LIAISON XL analyzer to support the proposed intended use statement and product labeling claims. Data collected may be used for an FDA submission of the LIAISON LymeDetect assay and shall comply with the IVDR for CE registration.

Colby-Abbotsford Center

111 DEHNE DRIVE

COLBY, WI 54421

Eagle River Center

500 COMMERCE LOOP

EAGLE RIVER, WI 54521

Greenwood Center

102 W CANNERY STREET

GREENWOOD, WI 54437

Marshfield Medical Center - Rice Lake

1700 W STOUT ST

RICE LAKE, WI 54868

MC - Chippewa Falls Center

2655 CTY HWY I

CHIPPEWA FALLS, WI 54729

MC - Lake Hallie Center

12961 27TH AVE

CHIPPEWA FALLS, WI 54729

MC - Wausau Center

2727 PLAZA DRIVE

WAUSAU, WI 54401

MMC - Eau Claire

2116 Craig Rd

Eau Claire, WI 54701

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

MMC - Minocqua

9601 TOWNLINE RD

MINOCQUA, WI 54548

MMC - Neillsville

216 Sunset Place

Neillsville, Wisconsin 54456

MMC - Weston

3501 CRANBERRY BLVD

WESTON, WI 54476

Stratford Center

101 WISCONSIN AVE

STRATFORD, WI 54484