Clinical Trials

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Enrolling Trials

51-60  of  143
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APEC1621F, NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice)- Phase 2 Subprotocol of Ensartinib in Patients with Tumors Harboring ALK or ROS1 Genomic Alterations
Brandt, Jon
Mutations
Child
This phase II trial studies how well ensartinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with ALK or ROS1 genomic alterations that have come back or do not respond to treatment and have spread to other places in the body. Ensartinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Welter, Stacy L
(715) 221-6492
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APEC1621SC, NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol
Brandt, Jon
Mutations
Child, Adult
This screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists that has been shown to prolong survival. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic changes or abnormalities (mutations) may benefit more from treatment which targets their tumor's particular genetic mutation, and may help doctors plan better treatment for patients with solid tumors or non-Hodgkin lymphomas.
Welter, Stacy L
(715) 221-6492
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI  54449
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APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Adjuvant Chemotherapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
Abdelhadi, Kareem H
Rare Tumors - Pancreas
Adult
This phase II trial investigates how well the addition of olaparib following completion of surgery and chemotherapy works in treating patients with pancreatic cancer that has been surgically removed (resected) and has a pathogenic mutation in BRCA1, BRCA2, or PALB2. Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Blocking PARP may help keep tumor cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy.
Wilson, Anna E
(715) 858-6860
Marshfield Medical Center - Rice Lake
1700 W STOUT ST
RICE LAKE, WI  54868
MMC - Eau Claire Cancer Center
2200 Craig Road
Eau Claire, WI  54701
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI  54449
MMC - Minocqua
9601 TOWNLINE RD
MINOCQUA, WI  54548
MMC - River Region at Stevens Point
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MMC - Weston
3501 CRANBERRY BLVD
WESTON, WI  54476
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AREN03B2, Renal Tumors Classification, Biology, and Banking Study
Brandt, Jon
Biology
Child
This research trial studies kidney tumors in younger patients. Collecting and storing samples of tumor tissue, blood, and urine from patients with cancer to study in the laboratory may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer.
Welter, Stacy L
(715) 221-6492
Marshfield Medical Center
611 Saint Joseph Ave
Marshfield, WI  54449
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI  54449
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Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery
Bauer, Anderson
Head/Neck
Adult
Evaluate the structure preservation rate for patients with locally advanced resectable NPNSCC with or without neoadjuvant therapy; all patients will undergo surgical resection and postoperative standard care.
Diagnostic & Treatment Center
3401 CRANBERRY BLVD
WESTON, WI  54476
Marshfield Medical Center - Rice Lake
1700 W STOUT ST
RICE LAKE, WI  54868
MC - Wausau Center
2727 PLAZA DRIVE
WAUSAU, WI  54401
MMC - Eau Claire
2116 Craig Rd
Eau Claire, WI  54701
MMC - Eau Claire Cancer Center
2200 Craig Road
Eau Claire, WI  54701
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI  54449
MMC - Minocqua
9601 TOWNLINE RD
MINOCQUA, WI  54548
MMC - River Region at Stevens Point
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MMC - Weston
3501 CRANBERRY BLVD
WESTON, WI  54476
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CIRB, Understanding the Impact of Drug Shortages on Oncology Care Delivery
Delmastro, Dean A
Oncology
Adult
The primary objective of the study is to prospectively estimate the proportion of NCORP community practices that experience a cancer care delivery problem attributable to a drug shortage of infusional therapeutic oncology drugs. Drug shortages are determined using the Utah Drug Information Service database that identifies drug shortages in real time. Secondary objectives are: To prospectively estimate the rate of cancer care delivery problems (defined above) attributable to a drug shortage of infusional therapeutic oncology drugs for patient populations treated with: a) all cancer drugs, b) all cancer drugs in shortage, and c) each individual cancer drug in shortage. Exploratory objectives are: To assess practice factors (e.g., case mix, size, and practice type) associated with the likelihood that a practice reports cancer care delivery problems. To describe how practice-level strategies in response to drug shortages vary by practice characteristics. To describe the possible effects on clinical trials (e.g., unable to enroll a patient or changing to an alternative treatment). To characterize cancer care delivery problems attributable to a shortage of supportive care agents. To characterize cancer care delivery problems attributable to a shortage of oral anti-cancer agents.
Ottosen, Rebecca
(715) 393-1471
MMC - Eau Claire Cancer Center
2200 Craig Road
Eau Claire, WI  54701
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Clinical Registry Investigating Bardet-Biedl Syndrome
Pomeroy, Jeremy J
Nephrology - Other
Child, Adult
The purpose of the Clinical Registry Investigating Bardet-Biedl Syndrome (CRIBBS) is to establish and perpetuate an international registry enabling subject recruitment for clinical natural history studies, therapeutic trials and collection of biological specimens of blood and saliva specimens of affected individuals and family members with a rare disorder, Bardet-Biedl syndrom (BBS). Biological specimens will be collected for future clinical studies, as well as other studies to examine the relationship between genetic mutations and clinical features. Specimens will be stored in the Core Laboratory.
Marshfield Clinic Research Institute
1000 N OAK AVE
Marshfield, WI  54449
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI  54449
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Collection of Whole Blood to be Used to Provide the Safety and Effectivenss of a Lyme Disease Diagnostic Assay to Support the Proposed Intended Use Statement and Product Labeling Claims
Schotthoefer, Anna M
Infectious Disease
Child, Adult
The general study objective is to obtain sufficient data from a well-controlled prospective clinical study compliant to 21 CRF 812, to provide evidence for the safety and effectiveness of the LIAISON LymeDetect assay using the LIAISON XL analyzer to support the proposed intended use statement and product labeling claims. Data collected may be used for an FDA submission of the LIAISON LymeDetect assay and shall comply with the IVDR for CE registration.
Gault, Tammy
(715) 387-5673
Kauffman, Lisa D
(715) 389-5738
Kohl, Stephanie
Kohnhorst, Diane
(715) 221-6099
Landin, Ann-Marie L
McGreevey, Karen M
(715) 389-3528
Mundt, Pamela S
(715) 387-5544
Serbiak, Adreanna R
Colby-Abbotsford Center
111 DEHNE DRIVE
COLBY, WI  54421
Eagle River Center
500 COMMERCE LOOP
EAGLE RIVER, WI  54521
Greenwood Center
102 W CANNERY STREET
GREENWOOD, WI  54437
Marshfield Medical Center - Rice Lake
1700 W STOUT ST
RICE LAKE, WI  54868
MC - Chippewa Falls Center
2655 CTY HWY I
CHIPPEWA FALLS, WI  54729
MC - Lake Hallie Center
12961 27TH AVE
CHIPPEWA FALLS, WI  54729
MC - Wausau Center
2727 PLAZA DRIVE
WAUSAU, WI  54401
MMC - Eau Claire
2116 Craig Rd
Eau Claire, WI  54701
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI  54449
MMC - Minocqua
9601 TOWNLINE RD
MINOCQUA, WI  54548
MMC - Weston
3501 CRANBERRY BLVD
WESTON, WI  54476
Stratford Center
101 WISCONSIN AVE
STRATFORD, WI  54484
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CORRECT- MRD II: Second COloRectal cancer clinical validation study to predict REcurrence using a Circulating Tumor DNA assay to detect Minimal Residual Disease
Onitilo, Adedayo A
Stomach, Intestine, Gut - Rectum
Adult
C-14 is a prospective multicenter study that will enroll patients who have undergone complete surgical resection for stage II or III colorectal cancer (CRC), who have sufficient residual formalin-fixed paraffin-embedded (FFPE) tissue available from the primary resection for research testing and are willing to provide FFPE and serial whole blood samples for circulating tumor DNA(ctDNA) analysis.
Marshfield Medical Center - Rice Lake
1700 W STOUT ST
RICE LAKE, WI  54868
MMC - Eau Claire
2116 Craig Rd
Eau Claire, WI  54701
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI  54449
MMC - Minocqua
9601 TOWNLINE RD
MINOCQUA, WI  54548
MMC - River Region at Stevens Point
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MMC - Weston
3501 CRANBERRY BLVD
WESTON, WI  54476
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Daratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM)
Fagbemi, Seth O
Plasma Cell, Bone Marrow
Adult
This phase III trial studies how well lenalidomide and dexamethasone works with or without daratumumab in treating patients with high-risk smoldering myeloma. Drugs used in chemotherapy, such as lenalidomide and dexamethasone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as daratumumab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Giving lenalidomide and dexamethasone with daratumumab may work better in treating patients with smoldering myeloma.
Diagnostic & Treatment Center
3401 CRANBERRY BLVD
WESTON, WI  54476
Marshfield Medical Center - Rice Lake
1700 W STOUT ST
RICE LAKE, WI  54868
MC - Wausau Center
2727 PLAZA DRIVE
WAUSAU, WI  54401
MMC - Eau Claire Cancer Center
2200 Craig Road
Eau Claire, WI  54701
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI  54449
MMC - Minocqua
9601 TOWNLINE RD
MINOCQUA, WI  54548
MMC - River Region at Stevens Point
,   
MMC - Weston
3501 CRANBERRY BLVD
WESTON, WI  54476