Clinical Trials
Enrolling Trials
41-50 of 124
AOST2031-A Phase 3 Randomized Controlled Trial
Comparing Open vs Thoracoscopic Management of
Pulmonary Metastases in Patients With Osteosarcoma
Brandt, Jon
Osteosarcoma
Child
This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery is a type of surgery done through a single larger incision (like a large cut) that goes between the ribs, opens up the chest, and removes the cancer. Thoracoscopy is a type of chest surgery where the doctor makes several small incisions and uses a small camera to help with removing the cancer. This trial is being done evaluate the two different surgery methods for patients with osteosarcoma that has spread to the lung to find out which is better.
Welter, Stacy L
(715) 221-6492
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI 54449
APEC14B1, The Project: Every Child Protocol: A Registry, Eligibility Screening, Biology and Outcome Study
Brandt, Jon
Biology
Child
This research trial studies the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.
Welter, Stacy L
(715) 221-6492
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI 54449
APEC1621F, NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice)- Phase 2 Subprotocol of Ensartinib in Patients with Tumors Harboring ALK or ROS1 Genomic Alterations
Brandt, Jon
Mutations
Child
This phase II trial studies how well ensartinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with ALK or ROS1 genomic alterations that have come back or do not respond to treatment and have spread to other places in the body. Ensartinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Welter, Stacy L
(715) 221-6492
APEC1621SC, NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol
Brandt, Jon
Mutations
Child, Adult
This screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists that has been shown to prolong survival. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic changes or abnormalities (mutations) may benefit more from treatment which targets their tumor's particular genetic mutation, and may help doctors plan better treatment for patients with solid tumors or non-Hodgkin lymphomas.
Welter, Stacy L
(715) 221-6492
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI 54449
APOLLO: A Randomized Phase II Double-Blind Study of
Olaparib Versus Placebo Following Adjuvant
Chemotherapy in Patients With Resected Pancreatic
Cancer and a Pathogenic BRCA1, BRCA2 or PALB2
Mutation
Abdelhadi, Kareem H
Rare Tumors - Pancreas
Adult
This phase II trial investigates how well the addition of olaparib following completion of surgery and chemotherapy works in treating patients with pancreatic cancer that has been surgically removed (resected) and has a pathogenic mutation in BRCA1, BRCA2, or PALB2. Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Blocking PARP may help keep tumor cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy.
Wilson, Anna E
(715) 858-6860
Marshfield Medical Center - Rice Lake
1700 W STOUT ST
RICE LAKE, WI 54868
MMC - Eau Claire Cancer Center
2200 Craig Road
Eau Claire, WI 54701
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI 54449
MMC - Minocqua
9601 TOWNLINE RD
MINOCQUA, WI 54548
MMC - River Region at Stevens Point
,
MMC - Weston
3501 CRANBERRY BLVD
WESTON, WI 54476
AREN03B2, Renal Tumors Classification, Biology, and Banking Study
Brandt, Jon
Biology
Child
This research trial studies kidney tumors in younger patients. Collecting and storing samples of tumor tissue, blood, and urine from patients with cancer to study in the laboratory may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer.
Welter, Stacy L
(715) 221-6492
Marshfield Medical Center
611 Saint Joseph Ave
Marshfield, WI 54449
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI 54449
CIRB, Understanding the Impact of Drug Shortages on
Oncology Care Delivery
Delmastro, Dean A
Oncology
Adult
The primary objective of the study is to prospectively estimate the proportion of NCORP community practices that experience a cancer care delivery problem attributable to a drug shortage of infusional therapeutic oncology drugs. Drug shortages are determined using the Utah Drug Information Service database that identifies drug shortages in real time. Secondary objectives are: To prospectively estimate the rate of cancer care delivery problems (defined above) attributable to a drug shortage of infusional therapeutic oncology drugs for patient populations treated with: a) all cancer drugs, b) all cancer drugs in shortage, and c) each individual cancer drug in shortage. Exploratory objectives are: To assess practice factors (e.g., case mix, size, and practice type) associated with the likelihood that a practice reports cancer care delivery problems. To describe how practice-level strategies in response to drug shortages vary by practice characteristics. To describe the possible effects on clinical trials (e.g., unable to enroll a patient or changing to an alternative treatment). To characterize cancer care delivery problems attributable to a shortage of supportive care agents. To characterize cancer care delivery problems attributable to a shortage of oral anti-cancer agents.
Bulgrin, Angela M
(715) 221-7261
MMC - Eau Claire Cancer Center
2200 Craig Road
Eau Claire, WI 54701
Clinical Registry Investigating Bardet-Biedl Syndrome
Pomeroy, Jeremy J
Nephrology - Other
Child, Adult
The purpose of the Clinical Registry Investigating Bardet-Biedl Syndrome (CRIBBS) is to establish and perpetuate an international registry enabling subject recruitment for clinical natural history studies, therapeutic trials and collection of biological specimens of blood and saliva specimens of affected individuals and family members with a rare disorder, Bardet-Biedl syndrom (BBS). Biological specimens will be collected for future clinical studies, as well as other studies to examine the relationship between genetic mutations and clinical features. Specimens will be stored in the Core Laboratory.
Perales, Honeliz
Perales, Honeliz
Saucedo, Juan P
(715) 389-4018
Marshfield Clinic Research Institute
1000 N OAK AVE
Marshfield, WI 54449
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI 54449
CORRECT- MRD II: Second COloRectal cancer clinical
validation study to predict REcurrence using a Circulating
Tumor DNA assay to detect Minimal Residual Disease
Onitilo, Adedayo A
Stomach, Intestine, Gut - Rectum
Adult
C-14 is a prospective multicenter study that will enroll patients who have undergone complete surgical resection for stage II or III colorectal cancer (CRC), who have sufficient residual formalin-fixed paraffin-embedded (FFPE) tissue available from the primary resection for research testing and are willing to provide FFPE and serial whole blood samples for circulating tumor DNA(ctDNA) analysis.
Kidwell, Anna
Marshfield Medical Center - Rice Lake
1700 W STOUT ST
RICE LAKE, WI 54868
MMC - Eau Claire
2116 Craig Rd
Eau Claire, WI 54701
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI 54449
MMC - Minocqua
9601 TOWNLINE RD
MINOCQUA, WI 54548
MMC - River Region at Stevens Point
,
MMC - Weston
3501 CRANBERRY BLVD
WESTON, WI 54476
Daratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM)
Fagbemi, Seth O
Plasma Cell, Bone Marrow
Adult
This phase III trial studies how well lenalidomide and dexamethasone works with or without daratumumab in treating patients with high-risk smoldering myeloma. Drugs used in chemotherapy, such as lenalidomide and dexamethasone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as daratumumab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Giving lenalidomide and dexamethasone with daratumumab may work better in treating patients with smoldering myeloma.
Kidwell, Anna
Diagnostic & Treatment Center
3401 CRANBERRY BLVD
WESTON, WI 54476
Marshfield Medical Center - Rice Lake
1700 W STOUT ST
RICE LAKE, WI 54868
MC - Wausau Center
2727 PLAZA DRIVE
WAUSAU, WI 54401
MMC - Eau Claire Cancer Center
2200 Craig Road
Eau Claire, WI 54701
MMC - Marshfield
1000 N OAK AVE
MARSHFIELD, WI 54449
MMC - Minocqua
9601 TOWNLINE RD
MINOCQUA, WI 54548
MMC - River Region at Stevens Point
,
MMC - Weston
3501 CRANBERRY BLVD
WESTON, WI 54476